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2.
Breast ; 22(3): 295-300, 2013 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-22999459

RESUMO

The goal of this study was CGH array profiling of breast cancer from Malian women in order to define differences with those from USA. CGH array was performed in 28 samples, 17 with a triple negative phenotype. The profiles were compared to those of 106 tumors from USA. 6 chromosomal regions (6p21, 9q34, 11q13, 12q24, 17q25 and 22q12.1-22q13.1) were identified with a significant higher rate of copy number alterations. These regions contain several genes of interest including BCR. FISH and IHC confirmed that BCR was amplified and overexpressed particularly in triple negative tumors. Finally, 5 regions presented a high level of amplification in two or more samples, including 2 regions located between 9p22.3-9p23 and 9p23-9p24.1. This study confirms that breast cancers from African women present biological differences with those from USA. Larger studies are needed to go further in the identification of therapeutic targets that would be specific to African women.


Assuntos
População Negra/genética , Dosagem de Genes , Proteínas Proto-Oncogênicas c-bcr/genética , Neoplasias de Mama Triplo Negativas/genética , Cromossomos Humanos Par 6 , Hibridização Genômica Comparativa , Feminino , Amplificação de Genes , Expressão Gênica , Humanos , Mali , Pessoa de Meia-Idade , Estados Unidos
4.
S Afr J Surg ; 49(4): 204-5, 2011 Nov 30.
Artigo em Inglês | MEDLINE | ID: mdl-22353274

RESUMO

A 27-year-old woman, gravida 1, was seen at our surgical emergency department with abdominal pain at 25 weeks' gestation. She had pain, nausea and vomiting, a temperature of 37°C and a blood pressure of 100/70 mmHg. The cervix was closed, and an ultrasound scan showed a normal single fetus. A plain abdominal radiograph showed distension of the colon and a sigmoid volvulus. At emergency laparotomy, non-gangrenous sigmoid colon was resected with primary anastomosis. There were no complications, and 4 months later the patient delivered a healthy infant. Early diagnosis of sigmoid volvulus in pregnancy and prompt intervention minimise maternal and fetal morbidity and mortality.


Assuntos
Volvo Intestinal/diagnóstico , Volvo Intestinal/cirurgia , Complicações na Gravidez/diagnóstico , Complicações na Gravidez/cirurgia , Doenças do Colo Sigmoide/diagnóstico , Doenças do Colo Sigmoide/cirurgia , Adulto , Feminino , Humanos , Gravidez
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