[The relation of a number of hormonal indices to risk factors for IHD and its prevalence based on the data from a large population study]. / Sviaz' riada gormonal'nykh pokazatelei s faktorami riska IBS i ee rasprostranennost'iu po dannym krupnogo populiatsionnogo issledovaniia.

Relevance of IHD risk factors and hormone concentrations (insulin, estradiol, testosterone, prolactin, LH, FSH, TTH and hydrocortisone) to IHD incidence was studied in 1200 men. Multivariate statistical analysis demonstrated that only a small number of hormonal indices are associated with main lipid and nonlipid risk factors. The relationships exist between systolic arterial pressure (SAP) and hydrocortisone, between TTH and total cholesterol, SAP and age, estradiol, testosterone and age. Significant independent associations were found between IHD prevalence and age (R = 0.140, 3 = 0.000), SAP (R = 0.130, P.0.001), HDLP cholesterol (R = -0.082, P = 0.007), height (R = -0.078, P = 0.010), insulin (R = 0.067, P = 0.035), standard deviation of estradiol from median value (R = 0.083, P = 0.017). The findings confirm a great role of high SAP in the development of IHD, a significant and independent association of high insulin levels with IHD prevalence, the presence of nonlinear relation of estradiol concentration to IHD occurrence in males.

[The effect of pharmacological preparations on the regulation of growth hormone secretion]. / Vliianie nekotorykh farmakologicheskikh preparatov na reguliatsiiu sekretsii gormona rosta.

The authors have assessed the effects of 7 metabolic and 5 neutral drugs and their combinations on the basal blood concentration of the growth hormone (GH) and on the sensitivity of GH-regulating centers to homeostatic glucose inhibition. No significant changes in GH basal level were revealed. Nacom and a combination of vitamins E and C reduced the threshold sensitivity to glucose inhibition of the GH, whereas miscleron and trental elevated this threshold sensitivity. A combination of butamid and nacom had the highest stimulatory effect on the cellular immunity and macrophagal function, that may be mediated by enhanced GH secretion. In subjects with the 'superior' (android) type of obesity GH basal concentration and its sensitivity to glucose inhibition were lower than in those with the 'inferior' (gynoid) type, this being true after the drug discontinuation.

[Detection of antibodies to adipose tissue cell membranes in human blood]. / Obnaruzhenie antitel k kletochnym membranam zhirovoi tkani v syvorotke krovi liudei.

In serum of some healthy women and patients with fibroadenomatosis of the mammary gland antibodies to the cell membranes of adipocytes were detected. Interconnections between these antibodies and corresponding antigens in blood, on the one hand, and hormonal-metabolic status of probands, on the other hand, were observed. Possible autoimmune origin of phenomenon detected and its relation to the normal and pathological processes in adipose tissue are discussed.

[Aromatase activity in lymphocytes of cancer patients and healthy subjects]. / Aktivnost' aromatazy v limfotsitakh onkologicheskikh bol'nykh i zdorovykh liudei.

Conversion of androgens (aromatization) to estrogens in lymphocytes of cancer patients and healthy subjects in vitro was discovered. Aromatase activity in lymphocytes was comparable to that of fat and breast tumor tissues. It was completely suppressed in one out of two breast cancer patients receiving orimeten (aminoglutethimide). The activity in large bowel cancer was lower than in adenoma patients; however, the two groups were not balanced for age.

[Hyperprolactinemia as a marker of the progression of cervical cancer]. / Giperprolaktinemiia kak marker progressii raka sheiki matki.

Elevated blood prolactin level was identified in 80% of untreated patients with advanced (stage II-IV) cervical cancer whereas it was normal at the earlier (preinvasive) stage. Patients with stage I-A, II tumors revealed either increased or normal blood prolactin level. Patients with advanced cancer who had undergone irradiation and surgery, either alone or in combination, showed hyperprolactinemia as often as 94% of the time. Studies on pathogenesis of hyperprolactinemia and its role in tumor progression are currently conducted by the authors.

[Aging and cancer: the foundation of strategies of ontogenetic prophylaxis]. / Starenie i rak: obosnovanie strategii ontogeneticheskoi profilaktiki.

According to the recent conceptions the ecological harmful factors are the main causes producing the cancer appearance, especially of the age-dependent elevation of its incidence. It is known that the key element of cancer prevention is a decrease or removal of exogenous carcinogens. Such a way can lead to the decrease of the cancer incidence in the young and middle aged persons and to the increase of the cancer frequency in the old age, i.e. to the increase of the cancer incidence in population on the whole, because metabolic conditions promoting the cancer appearance in an organism regularly appear in the process of aging. These conditions arise as a by-product of the organism developmental programme. New approaches to the cancer prevention are considered as based on principles of the ontogenetic prevention.

[Effect of tamoxifen on the content of cytoplasmic steroid hormone receptors of the tumor in patients with cancer of the corpus uteri]. / Vliianie tamoksifena na soderzhanie tsitoplazmaticheskikh retseptorov steroidnykh gormonov v opukholi u bol'nykh rakom tela matki.

A direct correlation between steroid hormone receptor level, tumor differentiation and pathogenetic pattern of tumor was established in 49 patients with endometrial carcinoma. Dynamics of tamoxifen-induced changes in progesterone receptor level proved an important criterion of hormone dependence of endometrial tumor.

[Body weight, blood lipids, blood cortisol and prognosis of patients with cancer of the large intestine and breast]. / Massa tela, lipidemiia, kortizolemiia i prognoz u bol'nykh rakom tolstoi kishki i molochnoi zhelezy.

Survival was evaluated in 121 patients with breast cancer and 114 with colorectal tumors versus overweight, body surface, preoperative blood-cholesterol level, cholesterol fraction profile and blood-triglyceride and -11-hydroxycorticosteroid levels. Survival was assessed by actuarial method. In breast cancer patients, prognosis inversely correlated with overweight and preoperative blood-cholesterol level whereas in colorectal cancer--with preoperative blood-triglyceride level, and--in males--with those of 11-hydroxycorticosteroids. The prognostic significance of cancrophilia factors in cancer as well as differences in said significance for colorectal and breast tumors are discussed.

[Somatomedin activity of the blood: hormonal metabolic and immunological shifts in cancer patients]. / Somatomedinovaia aktivnost' krovi: gormonal'no-metabolicheskie i immunologicheskie sdvigi u onkologicheskikh bol'nykh.

Blood somatomedin activity observed in patients with cancer of the corpus uteri, breast, colon and rectum, pancreas, ovary and lung proved to exceed those in control by 140-300%. The said parameter was found to depend upon endocrine-metabolic changes, relatively higher levels being registered in overweight patients and those with hypertriglyceridemia. Changes of varying degree in somatomedin activity and growth hormone levels produced by insulin and glucose in patients with breast and uterine cancer pointed to hormonal dependence of the parameter. Also, the effect is a circumstantial evidence for negative feedback between growth hormone and somatomedin production. In patients with cancer of the breast, uterus and lung, a significant correlation was established between somatomedin activity, on the one hand, and monocyte. B-lymphocyte and T-active lymphocyte levels, on the other, matched by an inverse one with T-lymphocyte level and blastogenic reaction of lymphocytes.

[Capacity of rhabdomyosarcoma cells to produce substances with somatomedin and mitogenic activity]. / Sposobnost' kletok rabdomiosarkomy produtsirovat' veshchestva s somatomedinovoi i mitogennoi aktivnost'iu.

The rats aged 1, 3, 12 and 15 months were intravenously injected with 10,000 of the rhabdomyosarcoma cells. 3 weeks following the injection multiple tumour clones were observed in the lungs of experimental animals, the rats aged 1 and 15 months showing a significantly greater tumour yield than those aged 3 and 12 months. The level of the mitogenic and somatomedin activity increased both in the blood serum and in the lung tissue, the activity varying with the number of tumour clones. Rhabdomyosarcoma cells, probably, synthesize and release growth factors into the blood.

[Somatomedin activity in patients with malignant neoplasms]. / Somatomedinovaia aktivnost' u bol'nykh so zlokachestvennymi novoobrazovaniiami.

The effect of tumor on somatomedin level in blood was investigated. This index, which is generally high in patients with primary tumors of the breast, cervix uteri, colon rectum and prostate, was found to decrease in step with tumor progression (stages II-IV). In well--differentiated adenocarcinoma of the endometrium and large bowel, it was higher than in moderately- and poorly-differentiated forms. In breast cancer patients, a relatively high blood--somatomedin level was mostly observed in solid forms, this being matched by relatively high somatomedin levels in tumor tissue. The tissue of 60% of large bowel tumors was shown to produce an inhibitor of somatomedin activity. It is suggested that there is a relationship between blood-somatomedin level in cancer patients and tumor mediated by somatomedin-like and -inhibiting factors produced by it.

[Endocrine changes in children with acute viral hepatitis]. / Endokrinnye sdvigi u detei s ostrym virusnym gepatitom.

The paper is concerned with the results of hormonal studies on virus hepatitis in 84 children aged 2 to 14, of them 28 had a mild form of disease, 50--medium grave and 6--a severe form of disease. A study was made of the blood content of ACTH, STH, TSH, cortisol, aldosterone, T3, T4, prolactin, and alpha-fetoprotein. The hormones were determined by a radioimmunoassay using Sorin kits (France). A considerable increase in the blood content of ACTH, cortisol, aldosterone and a moderate increase in STH, TSH and T4 concentrations were noted at the height of virus hepatitis. The above changes were interpreted as a result of combined manifestation of a stress reaction and a decrease in the catabolism of some liver hormones. An assumption has been made of a possibility of the effect of late hormonal shifts on the outcome of virus hepatitis of development of chronic hepatitis.

[Immunocorrective therapy in esophageal cancer]. / Immunokorrigiruiushchaia terapiia pri rake pishchevoda.

Additional non-specific therapy including levamisole and other drugs was tested in 20 patients with esophageal cancer. Complex (immuno- and chemoradiation) treatment brought immune response, lipid metabolism and cortisol level to normal, which in most cases, was in correlation with the clinical effect of therapy.

[Characteristics of dyslipidemia in cancer patients]. / Osobennosti dislipidemii u onkologicheskikh bol'nykh.

Blood concentrations of total cholesterol, cholesterol of very high density lipoproteins (alpha-cholesterol), triglycerides, beta-lipoproteins and 11-hydroxycorticosteroids were studied in 560 patients with rectal, colon, lung, ovarian, breast and endometrial cancer as well as in 238 controls. Patients with breast and rectal cancer were examined before and repeatedly after operation (every 6-12 months within 4-5 years). The blood concentration of total cholesterol was found to be elevated in breast cancer patients and controls with fibroadenomatosis and decreased in females with ovarian cancer and males with lung cancer. The level of blood alpha-cholesterol was decreased in males with all tumor localizations under study and in females with ovarian and rectal cancer. The concentration of triglycerides was increased in women patients only. Three possible causes of dyslipidemia in cancer patients are discussed: its development before tumor manifestation, the effect of tumor on the metabolic status of the host and the role of emotional stress in the increase of triglycerides level in the blood of primary cancer patients.