RESUMO
AIM: Recent evidence suggests that omentin-1, a visceral adipose-derived cytokine, may play a role in atherosclerosis The aim of this study was to evaluate whether serum omentin-1 levels are associated with peripheral artery disease (PAD) and its severity. METHODS: The present study was cross-sectional and observational. We enrolled 123 patients with PAD and 50 age-matched subjects without PAD. The cardiovascular risk factors, ankle-brachial index (ABI), and serum omentin-1 levels were assessed in all participants RESULTS: Patients with PAD had significantly lower omentin-1 levels than those without PAD (206. ±48.4 vs. 345. ±80 ng/mL, respectively; 0.001). A correlation analysis revealed positive correlations between the omentin-1 level and the ABI ( 0.52, P=0.008). After adjusting for cardiovascular risk factors, a decreased omentin-1 level was found to be an independent predictor of both PAD and its severity as measured by ABI in multivariate logistic regression analysis. CONCLUSION: The current study suggests a strong association between decreased serum omentin-1 levels and PAD and its severity. Thus, omentin-1 may be a novel biomarker for PAD.
Assuntos
Citocinas/sangue , Lectinas/sangue , Doença Arterial Periférica/sangue , Idoso , Índice Tornozelo-Braço , Biomarcadores/sangue , Estudos de Casos e Controles , Distribuição de Qui-Quadrado , Estudos Transversais , Regulação para Baixo , Feminino , Proteínas Ligadas por GPI/sangue , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Análise Multivariada , Razão de Chances , Doença Arterial Periférica/diagnóstico , Doença Arterial Periférica/etiologia , Valor Preditivo dos Testes , Medição de Risco , Fatores de Risco , Índice de Gravidade de Doença , TurquiaAssuntos
Veia Femoral/diagnóstico por imagem , Trombose Venosa/diagnóstico por imagem , Adulto , Anticoagulantes/uso terapêutico , Eletrofisiologia , Feminino , Heparina de Baixo Peso Molecular/uso terapêutico , Humanos , Masculino , Ultrassonografia , Trombose Venosa/etiologia , Trombose Venosa/prevenção & controleRESUMO
We describe a complication after radiofrequency (RF) ablation of a left free wall accessory pathway that resulted in acute occlusion of proximal left anterior descending (LAD) coronary artery in a 32-year-old male non-cocaine abuser. An interesting feature is the site of coronary artery occlusion which is remote from the RF application site. The RF energy applications were performed in the left lateral annulus remote from the LAD. The occlusion was successfully treated with placement of an intracoronary stent.
Assuntos
Ablação por Cateter/efeitos adversos , Trombose Coronária/etiologia , Taquicardia Supraventricular/cirurgia , Adulto , Implante de Prótese Vascular , Angiografia Coronária , Trombose Coronária/diagnóstico por imagem , Trombose Coronária/cirurgia , Humanos , Masculino , Stents , Taquicardia Supraventricular/diagnóstico por imagemRESUMO
The possibility of exercise-induced myocardial ischemia due to mitral valve prolapse (MVP) in the absence of coronary artery disease was evaluated with single-photon emission computed tomographic analysis using thallium-201 and technetium-99m sestamibi in 72 patients with MVP. Exercise electrocardiography was positive in 5 patients (8%), but single-photon emission computed tomography was found to be normal in all patients, and exercise-induced chest pain, electrocardiographic changes, and arrhythmias were found not to be related to myocardial ischemia in patients with MVP.
Assuntos
Prolapso da Valva Mitral/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Adulto , Dor no Peito/diagnóstico , Dor no Peito/etiologia , Diagnóstico Diferencial , Dipiridamol/administração & dosagem , Ecocardiografia , Eletrocardiografia , Teste de Esforço , Feminino , Humanos , Injeções Intravenosas , Masculino , Pessoa de Meia-Idade , Isquemia Miocárdica/diagnóstico , Estudos Prospectivos , Compostos Radiofarmacêuticos/administração & dosagem , Reprodutibilidade dos Testes , Tecnécio Tc 99m Sestamibi/administração & dosagem , Vasodilatadores/administração & dosagemRESUMO
Although arrhythmias are common in hypertrophic cardiomyopathy (HCM), complete atrioventricular (AV) block is very unusual. A 27-year-old female presented with a recent history of syncope and exercise intolerance. ECG demonstrated complete AV block. Two-dimensional Doppler echocardiography revealed HCM with a 60 mmHg left ventricular outflow tract (LVOT) gradient. A temporary transvenous ventricular pacemaker was inserted urgently, and subsequently replaced by a permanent DDD pacemaker. All symptoms were eliminated. This symptomatic improvement was associated with complete disappearance of LVOT gradient at the time of implantation. No gradient was observed during early follow-up and at 6 months after DDD pacemaker implantation.
