RESUMO
INTRODUCTION: The association between interleukin-6 (IL-6) gene -572 G^C polymorphism and myocardial infarction (MI) risk has not been established. We adopted this meta-analysis for further insight into the case-control studies. MATERIALS AND METHODS: To investigate the genetic association, we searched multiple databases, including Web of Science, EMbase, CBM disc, PubMed and CNKI. Also, we manually identified the searched references. All the statistical analyses were conducted using Stata 11.0. RESULTS: A total of five studies were identified, involving 2,526 MI cases and 3,027 controls. The results revealed a significant association between IL-6 gene -572 G^C polymorphism and MI, implying that the IL-6 gene -572 C allele may be a protective factor for MI (for C allele vs K allele: OR = 0.85, 95% CI = 0.73-0.99, p = 0.041; for C/C vs G/G: OR = 0.55, 95% CI = 0.31-0.98, p = 0.044; for C/C vs G/C + G/G: OR = 0.60, 95% CI = 0.41-0.89, p = 0.011). However, in the subgroup analysis with regard to ethnicity, no significant correlation was identified between IL-6 gene -572 G^C polymorphism and MI among Europeans. CONCLUSION: The IL-6 gene -572 C allele may be a protective factor for MI. Future studies involving larger sample bases are still recommended.
RESUMO
Despite advances in diagnosis and treatment, the survival of non-small cell lung cancer (NSCLC) patients is poor. Further understanding of the disease mechanism and treatment strategies is required. Copines are a family of calcium-dependent phospholipid-binding proteins that are evolutionally conserved in various eukaryotic organisms and protists. Copine 1, encoded by CPNE1, is a soluble membrane-binding protein, which includes two tandem C2 domains at the N-terminus and an A domain at the Cterminus. A previous study reported that Copine 1 binds with various intracellular proteins via its A domain and C omain. However, the role of CPNE1 in lung cancer remains unclear. In the presented study, CPNE1 expression level was demonstrated to be positively associated with the stage (P=0.002) and significantly associated with lymph node status (P=0.011) and distant metastasis (P=0.042). Furthermore, the function of CPNE1 in regulation of cell growth, migration and invasion was investigated, and it was demonstrated that knockdown of CPNE1 inhibits the cell cycle in NSCLC cells. Collectively, these data suggest that CPNE1 is an oncogene in NSCLC and serves an important role in tumorigenesis of NSCLC progression.
