Attentional Bias of Individuals with Social Anxiety towards Facial and Somatic Emotional Cues in a Holistic Manner.

Attentional bias towards threatening information is a crucial factor contributing to the development and persistence of social anxiety. However, the attentional bias towards threat information and the preferential processing pattern of emotional cues in individuals with social anxiety disorder during integrated facial and physical stimuli processing remain unclear. In this study, we employed a dot-probe paradigm to investigate the attentional bias towards integrated emotions (facial-body) among students with high and low levels of social anxiety (Experiment 1). Experiments 2 and 3 examined the attentional bias of socially anxious individuals when faced with conflicting emotional cues from faces or bodies in relation to integrated emotions. The data revealed that participants both high and low levels of social anxiety participants exhibited accelerated orienting and biased attention towards facial-body emotional processing. When there was inconsistency between emotional cues from faces or bodies and integrated emotions, higher levels of social anxiety were associated with increased vigilance towards threatening faces or bodies. These findings underscore that individuals with social anxiety possess an ability to rapidly capture threatening cues during the processing of facial-body emotional stimuli while also demonstrating a tendency to avoid relying solely on facial cues by compensating through bodily cues for emotion perception.

The role of the left dorsolateral prefrontal cortex in conflict control during insomnia disorder.

BACKGROUND: Patients with insomnia are often accompanied by cognitive dysfunction, which seriously affects the quality of life of patients. Repetitive transcranial magnetic stimulation (rTMS) can induce brain neuroplasticity, regulate brain cognitive function and inhibitory control ability. OBJECTIVE: To explore the intervention effect of rTMS on conflict control and sleep quality in patients with insomnia. METHODS: In this single-blind, randomized controlled trial, 39 people with insomnia disorder were randomly divided into real stimulation group and sham stimulation group. The stimulation parameters were stimulation frequency 1 Hz, stimulation intensity 80 % resting motor threshold (RMT), total pulse number 1500 times, time 25 min, and the whole course of treatment lasted 7 days. The Insomnia Severity Index(ISI)、Pittsburgh Sleep Quality Index(PSQI)、Multidimensional Fatigue Inventory(MFI) and Beck Anxiety Inventory(BAI) were assessed at pretest (baseline) and posttest (day 7 after intervention), and the color-word stroop task was used to measure the conflict control ability of the subjects. RESULTS: The sleep quality, correct rate and reaction time of the posttest in the real stimulus group were higher than those in the pretest. However, there was no significant difference between the pretest and posttest in the sham stimulation group. CONCLUSIONS: rTMS stimulation of the left dorsolateral prefrontal cortex (LDLPFC) in patients with insomnia can significantly improve the conflict control ability and sleep quality of patients with insomnia.

Facial feedback manipulation influences the automatic detection of unexpected emotional body expressions.

Unexpected or changing facial expressions are known to be able to engage more automatic processing than frequently occurring facial expressions, thereby inducing a neural differential wave response known as expression mismatch negativity (EMMN). Recent studies have shown that EMMN can be modulated by the observer's facial feedback (i.e., feedback from their own facial movements). A similar EMMN activity has been discovered for body expressions, but thus far only a few emotion types have been investigated. It is unknown whether the EMMNs evoked by body expressions can be influenced by facial feedback. To explore this question, we recorded EEG activity of 29 participants in the reverse oddball paradigm. Here two unexamined categories of body expressions were presented, happy and sad, placed in two paired stimulus sequences: in one the happy body was presented with a probability of 80% (standards) while the sad body was presented with a probability of 20% (deviants), and in the other the probabilities were reversed. The facial feedback was manipulated by different pen holding conditions (i.e., participants holding the pen with the teeth, lips, or nondominant hand). The nonparametric cluster permutation test revealed significant happy and sad body-related EMMN (bEMMN) activities. The happy-bEMMN were more negative than sad-bEMMN within the range of 100-150 ms. Additionally, the bEMMN amplitude of both emotions is modulated by the facial feedback conditions. These results expand the range of emotional types applicable to bEMMN and provide evidence for the validity of the facial feedback hypothesis across emotional carriers.

Altered electrophysiology mechanism related to inhibitory control in adults with insomnia.

Background: Insomnia disorder (ID), one of the most common psychophysiological disorders, can cause a serious burden on the individual's work and academic performance. Cognitive dysfunction often exists in patients with insomnia, which negatively affects their living quality. Inhibitory control (IC), as a vital cognitive function, allows individuals to suppress attention, behavior, or thoughts that are irrelevant to the task, so as to effectively adapt to the current goal. The earlier studies on the inhibitory control of insomnia patients predominantly used subjective scales for evaluation and that can have drawbacks because they don't provide an objective assessment. Methods: In order to investigate the inhibitory control function of insomniacs, this research subdivides inhibitory control into response inhibition and conflict inhibition. The response inhibition and conflict inhibition capacities of insomniacs were evaluated using the two-choice oddball task and the color-word stroop task, and accordingly the association between insomnia disorder and inhibitory control capacity as well as its cognitive neural mechanism was able to be examined. Results: Behavioral results finding, insomniacs conducted the two-choice oddball test and the color-word stroop task with lower accuracy and slower reaction times when compared to healthy sleepers. ERP results finding, when performing the two-choice oddball task, the P3 amplitude of the insomniacs was significantly lower than that of healthy sleepers while there was no significant difference between the two groups' N2 amplitudes. At the same time, when completing the color-word stroop task, the insomniacs' N450 amplitude was significantly lower than that of healthy sleepers. Discussion: The above findings suggest that in response inhibition tasks, insomniacs may have weaker motor inhibition abilities, and similarly perform weaker conflict monitoring abilities in conflict inhibition tasks, which indicates that insomniacs' inhibitory control is impaired compared to that of healthy sleepers. This study thus relates to the finding at the electrophysiological level that there is a certain correlation between insomnia and a decline in inhibitory control ability, which may suggest that improving inhibitory control function in patients with insomnia is a clinically significant and worthwhile area of adjuvant treatment.

Impaired Neurological Activity in the Mental Rotation Ability of Tibetan Indigenous Residents After Chronic Exposure to High Altitude.

Mental rotation is a core indicator of spatial ability, and a threshold for cognitive impairment may exist at approximately 4,000 m above sea level, but the specific thresholds for the severity of hypoxia in Tibetan indigenous populations in mental rotation ability remain largely unknown. To determine whether a threshold for mental rotation impairment exists in indigenous residents, we related a mental rotation task to inter-individual differences in a range of behavioral performance and neuropsychological characteristics across 51 indigenous Tibetan highlanders and 34 matched controls at three different altitudes (sea level, 2,900 m, and 4,200 m). Analyses of reaction time showed delayed behavioral responses in the 4,200 m altitude group. Further analyses of rotation-related negativity (RRN) revealed that the RRN was significantly more negative and the differences disappeared gradually for different angles among individuals exposed to an altitude of 4,200 m. Moreover, a time-frequency analysis showed significantly enhanced alpha- and beta-band power values for the 4,200 m altitude participants after stimulus presentation. The impairment in mental rotation ability is related to hypoxia and can be attributed to the absence of sufficient cognitive resources, which demonstrates the existence of a threshold for the effects of high altitude on the brain's mental rotation ability. Taken together, our findings have important implications for exploring the altitude threshold for the influence of high-altitude exposure on brain function, as well as for guiding the development of innovative strategies to optimize the response of the organism against chronic hypoxia-induced under extreme environments.

Isoindigo-Based Dual-Acceptor Conjugated Polymers Incorporated Conjugation Length and Intramolecular Charge Transfer for High-Efficient Photothermal Conversion.

Photothermal tumor therapy (PTT) and photoacoustic imaging (PA) have emerged as promising noninvasive diagnostic and therapeutic approaches for cancer treatment. However, the development of efficient PTT agents with high photostability and strong near-infrared (NIR) absorption remains challenging. This study synthesizes three isoindigo-based dual-acceptor conjugated polymers (CPs) (P-IIG-TPD, P-IIG-DPP, and P-IIG-EDOT-BT) via a green and nontoxic direct arylation polymerization (DArP) method and characterizes their optical, electrochemical, and NIR photothermal conversion properties. By incorporating two acceptors into the backbone, the resulting polymers exhibit enhanced photothermal conversion efficiency (PCE) due to improved synergy among conjugation length, planarity, and intramolecular charge transfer (ICT). The nanoparticles (NPs) of P-IIG-EDOT-BT and P-IIG-DPP have a uniform size distribution around 140 nm and exhibit remarkable NIR absorption at 808 nm. In addition, P-IIG-EDOT-BT and P-IIG-DPP NPs exhibit high PCEs of 62% and 78%, respectively. This study promotes the molecular design of CPs as NIR photothermal conversion materials and provides guidance for the development of novel dual-acceptor CPs for tumor diagnosis and treatment.

The effect of repetitive transcranial magnetic stimulation on electroencephalography microstates of patients with heroin-addiction.

The effects of transcranial magnetic stimulation in treating substance use disorders are gaining attention; however, most existing studies used subjective measures to examine the treatment effects. Objective electroencephalography (EEG)-based microstate analysis is important for measuring the efficacy of transcranial magnetic stimulation in patients with heroin addiction. We investigated dynamic brain activity changes in individuals with heroin addiction after transcranial magnetic stimulation using microstate indicators. Thirty-two patients received intermittent theta-burst stimulation (iTBS) over the left dorsolateral prefrontal cortex. Resting-state EEG data were collected pre-intervention and 10 days post-intervention. The feature values of the significantly different microstate classes were computed using a K-means clustering algorithm. Four EEG microstate classes (A-D) were noted. There were significant increases in the duration, occurrence, and contribution of microstate class A after the iTBS intervention. K-means classification accuracy reached 81.5%. The EEG microstate is an effective improvement indicator in patients with heroin addiction treated with iTBS. Microstates were examined using machine learning; this method effectively classified the pre- and post-intervention cohorts among patients with heroin addiction and healthy individuals. Using EEG microstate to measure heroin addiction and further exploring the effect of iTBS in patients with heroin addiction merit clinical investigation.

The impact of social motivation on the other-race effect under high and low social status.

The other-race effect refers to the phenomenon in which the chance of individuals misidentifying faces from other races more than their own race is significantly higher. This study explored the effect of motivation on the other-race effect by manipulating the social status of faces. The results showed that: (1) compared to other-race faces with low social status, when individuals' perceptions of the social status of other-race faces increased, individuals' recognition scores for high social status other-race faces increased, and the other-race effect disappeared, and (2) when individuals' perceptions of the social status of other-race faces decreased, there was no significant difference in individuals' recognition scores of other-race faces, of either high or low social status. These findings suggest that motivation has a significant impact on the other-race effect.

Influence of improved behavioral inhibition on decreased cue-induced craving in heroin use disorder: A preliminary intermittent theta burst stimulation study.

BACKGROUND: Impaired behavioral inhibition is a critical factor in drug addiction and relapse. Repetitive transcranial magnetic stimulation (rTMS) reduces the craving of heroin-addicted individuals for drug-related cues. However, it is unclear whether this technique also improves impaired behavioral inhibition and how improved behavioral inhibition affects craving. OBJECTIVE: The intermittent theta-burst stimulation (iTBS) has been recently shown to be non-inferior relative to rTMS for depression. Here, we aim to investigate the effect of iTBS on heroin-addicted individuals' behavioral inhibition and cue-induced craving and the relationship between the alteration of behavioral inhibition and craving. METHOD: 42 of 56 initially recruited individuals with the heroin-use disorder in the abstinent-course treatment were randomized to undergo active or sham iTBS to the left dorsolateral prefrontal cortex and received three daily iTBS treatments for 10 consecutive days. We measured participants' performance during a two-choice oddball task (80% standard and 20% deviant trials) and heroin-related cue-induced craving before and immediately after treatment. RESULTS: The group that received active iTBS showed significantly improved two-choice oddball task performance after 10 days of intervention compared to both pre-intervention and the group who received sham iTBS. Similarly, a significant reduction in cue-induced craving was observed after following the intervention in the active iTBS group but not the sham iTBS group. The moderation model indicated that iTBS categories play a significant moderating role in the relationship between accuracy cost changing and altered cue-induced craving. CONCLUSIONS: The iTBS treatment protocol positively affects behavioral inhibition in patients with heroin addiction. Improvements in behavioral inhibition can substantially reduce craving.

Abnormal brain oscillations and activation of patients with heroin use disorder during emotion regulation: The role of delta- and theta-band power.

BACKGROUND: Emotion dysregulation is a crucial component of substance use disorders in predisposition, maintenance, and relapse. Emotional regulation strategies are an important factor in emotion dysregulation. However, studies on heroin use disorder (HUD) patients' ability to use emotion regulation strategies are scarce. METHODS: Time-frequency-based analyses were used to compare the power of 33 patients with HUD and 28 healthy controls to elucidate whether patients with HUD have abnormal neural oscillations during passive viewing and emotion regulation strategies. Using the standardized low-resolution brain electromagnetic tomography algorithm (sLORETA), we estimated the possible sources of the anomalous band power. RESULTS: Compared to patients with HUD, healthy controls showed a stronger decrease in the power of the delta/theta band across all task conditions. The effect peaked at approximately 1300-1900 ms after stimulus onset and varied by task condition. The estimation of sLORETA suggested the frontal, parietal, and limbic lobes as possible generators. LIMITATIONS: We cannot exclude the potential influence of additional factors, such as sex, depression and anxiety levels, and polysubstance use, on the results. CONCLUSIONS: Patients with HUD have blunted arousal and impaired ability to use emotion regulation strategies. The abnormal patterns described above may be the underlying neurophysiological basis for this dysfunction. Future studies could combine different approaches to improve emotion dysregulation in patients with HUD to promote treatment outcomes.

Pollution and Cleaning of PDMS Pervaporation Membranes after Recovering Ethyl Acetate from Aqueous Saline Solutions.

The removal of volatile organic compounds (VOCs) from wastewater containing nonvolatile salts has become an important and interesting case of the application of the pervaporation (PV) process. The aim of this study was to evaluate the influence of salts on the PV removal of ethyl acetate from wastewater using a polydimethylsiloxane (PDMS) membrane. The fouled membrane was then characterized via scanning electron microscopy-energy-dispersive X-ray analysis (SEM-EDX) to investigate salt permeation. The membrane backflushing process was carried out by periodically flushing the permeate side of the tubular membrane. The results demonstrated that salts (NaCl and CaCl2) could permeate through the PDMS membrane and were deposited on the permeate side. The presence of salts in the feed solution caused a slight increase in the membrane selectivity and a decrease in the permeate flux. The flux decreased with increasing salt concentration, and a notable effect occurred at higher feed-salt concentrations. A permeate flux of up to 98.3% of the original flux was recovered when the permeation time and backflushing duration were 30 and 5 min, respectively, indicating that the effect of salt deposition on flux reduction could be mitigated. Real, organic, saline wastewater was treated in a pilot plant, which further verified the feasibility of wastewater PV treatment.

Automatic change detection of multiple facial expressions: A visual mismatch negativity study.

The rapid detection of changes in facial expressions is an important social and survival skill. The detection of multiple facial emotions includes not only the information of emotional valence but also differences in emotional valence, that is, emotional valence consistency and inconsistency. Thus, we explored whether changes in multiple facial expressions could be automatically detected, as indexed by the visual mismatch negativity (vMMN) response. Participants were presented with a set of facial stimuli while performing a visual facial identity detection task; the stimulus was presented in the center of the visual field. The facial stimuli set consisted of five different facial identities and were presented in an oddball sequence, with four peripherally expressing the same positive or negative emotion and one in the center expressing congruent or incongruent emotions. We found vMMN responses to changes in positive congruent deviant emotions between 210 and 320 ms and in all deviant emotions between 480 and 560 ms over bilateral temporal-occipital sites. In addition, at 480-520 ms, the positive congruent stimulus versus the incongruent stimulus and the negative incongruent stimulus versus the congruent stimulus induced more negative vMMN amplitude in the left temporal-occipital electrodes. This shows that individuals can automatically identify the changes in multiple faces' emotional differences (emotional valence inconsistency), and that the emotional valence of the target face affects the automatic processing of multi-face emotional valence differences information. Furthermore, these results can be utilized in future research investigating automatic processing mechanisms.

Reasonable design of NIR AIEgens for fluorescence imaging and effective photothermal/photodynamic cancer therapy.

The development of a multifunctional single molecule phototherapeutic agent with excellent fluorescence imaging, photothermal therapy and photodynamic therapy at the same time is still a challenging task, which mainly arises from the low absorbance of the molecule, and the complexity of energy dissipation and molecular design. Herein, four donor-acceptor (D-A) compounds were synthesized by linking triphenylamine (TPA), thiophene/thieno[3,2-b]thiophene and different cyano acceptor structures. In this design, we propose a molecular design strategy to redshift absorption and increase the molar extinction coefficient (ε) by enhancing electron-withdrawing acceptors and enlarging the π-conjugation plane unit. Due to the twisted structure of TPA, these compounds exhibit aggregation-induced emission (AIE) characteristics. Notably, these AIEgens have long emission wavelengths, excellent photostability, biocompatibility, photothermal stability and singlet oxygen (1O2) generation performance. Among them, the photothermal conversion efficiency of a compound (named TCF-SS-TPA NPs) can reach 84.5%. Cellular internalization and therapy showed that TCF-SS-TPA NPs have good biocompatibility, excellent cell bioimaging and cancer phototherapy capabilities in vitro. This study will stimulate the molecular design of multifunctional phototherapeutics to realize effective synergistic cancer therapy.

A self-oscillating gel system with complex dynamic behavior based on a time delay between the oscillations.

The time delay existing between the chemical oscillation and mechanical oscillation (C-M delay) in a self-oscillating gel (SOG) system is observable in previous experimental studies. However, how the C-M delay affects the dynamic behavior of a large anisotropic SOG has not been quantified or reported systematically. In this study, we observed that the oscillation period increases with a decrease in the cross-linking density of the anisotropic SOG, and this determined whether regular mechanical oscillation occurs. Unlike before, the disrupted mechanical oscillations interestingly tend to be regular and periodic under visible light, which is an inhibitor for the B-Z reaction incorporating the Ru complex as a catalyst (Ru-BZ reaction). Moreover, the study of the C-M delay at different scales has far-reaching implications for intelligent soft actuators.

The automatic detection of unexpected emotion and neutral body postures: A visual mismatch negativity study.

The ability to automatically detect emotional changes in the environment is crucial for social interaction. In the visual system, expression-related mismatch negativity (EMMN) reflects the automatic processing of emotional changes in facial expression. However, body postures also carry visual emotional information that can be recognized effectively and processed automatically, although their processing mechanism remains unknown. In this study, the reverse oddball paradigm was used to investigate the mismatch responses of unexpected fear and neutral body postures. The nonparametric cluster permutation test revealed significant fear and neutral visual mismatch negativity (vMMN) activities, and the fear-related vMMN was enhanced prior (130-230 ms) to the neutral vMMN (180-230 ms). The body-sensitive N190 component may partially account for the vMMN obtained in this study. The fearful body posture evoked a greater N190 response over the neutral body, and amplitudes of N190 were more negative in the deviant condition than the standard condition. Additionally, the body-related visual mismatch oscillatory responses were associated with enhancement of the alpha band oscillation, especially for the fearful body posture. These results expanded the applicable scope of body posture cues corresponding to mismatch signals, objectively defined the electrophysiological activities evoked, and revealed the processing bias toward negative emotion.

The ineffective emotion regulation strategies of heroin use disorder patients: An event-related potential study.

BACKGROUND: People with substance use disorders (SUDs) usually experience emotion dysregulation, which may be a consequence of or a risk factor for the development and maintenance of substance misuse. Despite growing evidence on emotion dysregulation among people with SUDs, relatively few studies have explored emotion dysregulation in heroin use disorder (HUD) patients. METHODS: Using event-related potentials (ERP), we compared the emotion regulation ability of 33 HUD patients and 30 healthy controls according to their average electroencephalogram amplitudes of the late positive potential (LPP) component in 400-1000 ms and 1000-2000 ms time windows, while viewing neutral and unpleasant emotional pictures, and using emotion regulation strategies (expressive suppression, cognitive reappraisal, and a combination) while viewing unpleasant pictures. We recorded their mood states and how successfully they used emotion regulation strategies in each block using 7-point scales. RESULTS: Relative to healthy controls, the LPP amplitudes of HUD patients were significantly lower when viewing emotional stimuli (pearlyLPP < 0.05) and using emotion regulation strategies (all p < 0.05). The left hemisphere was more active in healthy controls (pearlyLPP < 0.05, plateLPP < 0.01); there were no differences in scalp position activation among HUD patients. DISCUSSION: Compared to healthy controls, HUD patients' emotional arousal and emotion regulation ability were impaired, as reflected by the LPP component. Their abnormal scalp activation pattern may imply abnormal brain activity. Future research could explore this with electroencephalogram source analysis techniques, functional magnetic resonance imaging, or other technologies. Intervention effects for emotion dysregulation in HUD treatment are also worth exploring.

Incidence and Prognostic Value of Acute Coagulopathy After Extensive Severe Burns.

Acute burn-induced coagulopathy (ABIC) occurs after severe burns. However, the incidence, prognostic value, and clinical significance of ABIC after an extensive severe burn remain inconclusive due to wide variances in burn severity and coagulation profile evaluation timings in previous studies. This retrospective study explored the incidence and clinical and prognostic significance of early phase ABIC in 129 adult patients with extensive burns (>50% total body surface area [TBSA]) admitted to the burn centers of two hospitals within 10 hours postburn injury during 2009-2017. Demographics (age and sex) and clinical data (burn severity, vital signs, prehospital fluid replacement volume, hemodynamic parameters, coagulation profile, blood gas, and blood biochemical indicators) were collected upon admission. The incidence of ABIC in patients with severe burns and its relationship with their survival and clinical significance were analyzed. The average postburn interval was 5.7 ± 2.7 hours, and the incidence of ABIC was 31% (40/129). A logistic regression analysis identified ABIC as an independent predictor of 4-week severe mortality due to severe burn. The incidence of ABIC was significantly associated with the total burn area, lactic acid levels upon admission, and postburn admission interval, but not with the prehospital fluid replacement volume. In conclusion, approximately 30% of patients with severe burns developed ABIC within 10 hours postburn, and this condition strongly predicts 4-week mortality. Although burn severity and tissue ischemia/hypoxia are main risk factors for ABIC, the pathogenesis is not fully understood and should be explored in future studies.

Development of a facial-expression database of Chinese Han, Hui and Tibetan people.

Recently, cross-cultural facial-expression recognition has become a research hotspot, and a standardised facial-expression material system can significantly help researchers compare and demonstrate the results of other studies. We developed a facial-expression database of Chinese Han, Hui and Tibetan ethnicities. In this study, six basic human facial expressions (and one neutral expression) were collected from 200 Han, 220 Hui and 210 Tibetan participants who lived in these regions. Four experts on each ethnicity evaluated the facial-expression images according to the expressions, and only those achieving inter-rater agreement were retained. Subsequently, 240 raters evaluated these images according to the seven emotions and rated the intensity of the expressions. Consequently, 2980 images were included in the database, including 930 images of Han individuals, 962 images of Hui individuals and 1088 images of Tibetan individuals. In conclusion, the facial-expression database of Chinese Han, Hui and Tibetan people was representative and reliable with a recognition rate of over 60%, making it well-suited for cross-cultural research on emotions.

Automatic Change Detection of Emotional and Neutral Body Expressions: Evidence From Visual Mismatch Negativity.

Rapidly and effectively detecting emotions in others is an important social skill. Since emotions expressed by the face are relatively easy to fake or hide, we often use body language to gauge the genuine emotional state of others. Recent studies suggest that expression-related visual mismatch negativity (vMMN) reflects the automatic processing of emotional changes in facial expression; however, the automatic processing of changes in body expression has not yet been studied systematically. The current study uses an oddball paradigm where neutral body actions served as standard stimuli, while fearful body expressions and other neutral body actions served as two different deviants to define body-related vMMN, and to compare the mechanisms underlying the processing of emotional changes to neutral postural changes. The results show a more negative vMMN amplitude for fear deviants 210-260 ms after stimulus onset which corresponds with the negativity bias that was obtained on the N190 component. In earlier time windows, the vMMN amplitude following the two types of deviant stimuli are identical. Therefore, we present a two-stage model for processing changes in body posture, where changes in body posture are processed in the first 170-210 ms, but emotional changes in the time window of 210-260 ms.

Reprocessable and Multiple Shape Memory Thermosets with Reconfigurability.

Multiple shape memory thermosets for various engineering applications have been quickly developed in recent years, mainly due to their stable thermomechanical performance, environmental stability, excellent chemical, solvent resistance, etc. However, these thermosets are inherently non-recyclable due to their chemically crosslinked properties, and it is difficult to make the permanent shapes of these thermosets sophisticated and geometrically complex, which significantly restricts a great variety of engineering applications in the industry and technology fields, mainly due to the economic inefficiency and environmental impact. Here, a thermoset with recyclability, multiple shape memory effect (multi-SME), and permanent shape reconfiguration is reported. After recycling, it also exhibits excellent mechanical properties without sacrificing the excellent multi-SME, combined elasticity (shape memory), and solid state plasticity, which can be easily scaled up and generalized to a variety of dynamic covalent networks.