On-line status monitoring and surrounding environment perception of an underwater cable based on the phase-locked Φ-OTDR sensing system.

A newly designed phase-locked (PL) Φ-OTDR system was proposed and instrumented. Field tests of water impact, anchor damage towing and tide diagnosing were carried out in a natural freshwater lake as well as the East China Sea. Personnel movement trajectory monitoring and ship flow monitoring were carried out by a buried cable along the floodplain of the Yangtze River. It proved that the proposed system can monitor the real-time status and sense the surrounding environment of existing underwater communication cables, which could be helpful for the maintenance of the cable itself as well as underwater information collection.

A Space-Division Multiplexing Method for Fading Noise Suppression in the Φ-OTDR System.

Phase-sensitive time-domain reflectometry (Φ-OTDR) can be used for fully distributed long-distance vibration monitoring. There is a fading phenolmenon in the Φ-OTDR, which will cause the signal intensity somewhere to be too low to extract the phase of the signal without distortion. In this paper, the Φ-OTDR based on space-division multiplexing (SDM) is proposed to suppress fading and we used multi-core optical fiber (MCF) to realize SDM. While inheriting the previous optimization strategy, we proposed a strategy based on frequency spectral similarity to process multiple independent signals obtained by SDM. And we compared the two methods. Through the experiments, the distortion rate can be reduced from an average level of 9.34% to less than 2% under continuous running of 270 s, which proves that SDM is a reliable technical route to achieve fading suppression. This method can effectively improve the fading suppression capability of the existed commercial systems.

Development of potent inhibitors of the human microsomal epoxide hydrolase.

Microsomal epoxide hydrolase (mEH) hydrolyzes a wide range of epoxide containing molecules. Although involved in the metabolism of xenobiotics, recent studies associate mEH with the onset and development of certain disease conditions. This phenomenon is partially attributed to the significant role mEH plays in hydrolyzing endogenous lipid mediators, suggesting more complex and extensive physiological functions. In order to obtain pharmacological tools to further study the biology and therapeutic potential of this enzyme target, we describe the development of highly potent 2-alkylthio acetamide inhibitors of the human mEH with IC50 values in the low nanomolar range. These are around 2 orders of magnitude more potent than previously obtained primary amine, amide and urea-based mEH inhibitors. Experimental assay results and rationalization of binding through docking calculations of inhibitors to a mEH homology model indicate that an amide connected to an alkyl side chain and a benzyl-thio function as key pharmacophore units.