Periodontitis as a risk factor for organic erectile dysfunction: A case-control study in a sub-Saharan population.

Background: This study investigated the association between periodontitis and organic erectile dysfunction (ED) in a sub-Saharan population. Methods: This multicenter analytical study lasted from April to September 2021. A total of 114 patients (38 cases and 76 controls) were recruited and matched on age, diabetes, and smoking status. Medical history and ED were recorded, as well as the plaque index, bleeding index, maximum interdental clinical attachment loss (CALmax), maximum probing depth, clinically detectable furcation involv ement, number of teeth in the mouth, number of teeth lost for periodontal reasons, and tooth mobility. The analysis was performed with SPSS 20.0 with a significance threshold set at 5%. Results: The two study groups were comparable regarding sociodemographic characteristics. Periodontitis was present in 76.31% of cases and 75% of controls without a significant difference (P=0.878). Logistic regression showed a significant association between high blood pressure and ED with an OR=4.78 (95% CI: 1.80‒12.70). Periodontitis was not associated with ED (OR=1.52, 95% CI: 0.55‒4.16); however, severe periodontitis was significantly associated with severe ED (OR=1.44, 95% CI: 1.11‒1.85, and OR=1.68, 95% CI: 1.15‒2.44, respectively for CALmax and tooth loss). Conclusion: Within the limits of this study, periodontitis was not associated with organic ED. However, the severity of periodontal disease significantly increased in patients with organic ED.

Computation of the conditions for anti-angiogenesis and gene therapy synergistic effects: Sensitivity analysis and robustness of target solutions.

Both anti-angiogenesis and gene therapy involve complex processes depending on non-point parameters belonging to a space of values. To successfully overcome the challenges involved in their therapeutic approaches, there is a need to analyze the sensitivity of these parameters. In this paper, a new mathematical model that combines immune system stimulations, inflammatory processes associated with tumor development, and gene therapy aimed at enhancing the efficacy of both treatments are explored. Using the global sensitivity methods of Sobol and Morris, the most important parameters are estimated. Estimation of the sensitivity variance revealed a strong interdependence between the parameters. Also, determinations of the conditions for effective therapy lead to a target of reducing the cancer cell numbers by at least 50%. This opened the way for delimiting the parameter spaces making it possible to reach the treatment target in addition to enhancing the estimation of the minimum time of remission. The combination of therapies and sensitivity analysis have demonstrated the robustness of therapy success.

The witchweed Striga gesnerioides and the cultivated cowpea: A geographical and historical analysis of their West African distribution points to the prevalence of agro-ecological factors and the parasite's multilocal evolution potential.

The increasing severity of Striga gesnerioides attacks on cowpea across West Africa has been related to its prolificity, seed mobility and longevity, and adaptation to aridity, in a context of agricultural intensification. To understand this fast extension, we analyzed (1) the distributions of the crop and the witchweed with ecological niche modeling and multivariate climate analysis, and (2) the chronological information available from collections and the literature. The ecoclimatic envelope of S. gesnerioides attacks on cowpea is the same as on wild hosts. Consistently, the modeled distribution of cowpea infestations is closely similar to the simple superposition of the parasite model (involving all hosts) and the crop model. Striga gesnerioides infestations are restricted to the driest component of the cultivated cowpea ecoclimatic niche, corresponding to the Sahelian and Sudano-Sahelian belts and the Dahomey gap. Thus, the parasite distribution, determined by its own requirements, does not constrain cowpea cultivation under Guinean climates. The spatial and temporal distributions of S. gesnerioides field infestations are consistent with an earlier impact on cowpea production in eastern West Africa, related itself to a similar trend in cowpea cultivation intensification from Niger, Nigeria and Benin to Burkina Faso and Ghana. Mali and Senegal were affected later, and literature reports of Senegalese strains of S. gesnerioides from the wild developing virulence on cowpea offer a model for the diffusion of witchweed parasitism by multilocal evolution, through host-driven selection, instead of epidemic diffusion. A contrario, in Côte d'Ivoire, cowpea is much less widespread, so the parasite has remained confined to the wild compartment. Thus, both historical and ecogeographic analyses refute the vision of S. gesnerioides as an invader. Instead, they point to the increasing importance and intensification of the crop, and the consequent loss of biodiversity, as the main drivers of the extension and diversification of its crop-specific strains.

New classification of periodontal diseases (NCPD): an application in a sub-Saharan country.

PURPOSE: To determine the clinical and radiological profile of periodontitis according to the 2018 NCPD, in a Dakar (Senegal) based periodontal clinic. METHODS: This is a descriptive study based on patient's records in the periodontology clinic. The study was conducted between November 2018 and February 2020 (15 months). All periodontitis cases were included in the study. Incomplete records (due to lack of radiographic workup or unusable periodontal charting) were excluded. Periodontitis diagnosis was established based on criteria used in the 2018 NCPD. Statistical analysis was carried out using SPSS version 20.0, with the significance threshold set at 0.05. RESULTS: A total number of 517 patient records were collected during the study period but only 127 periodontitis records were complete. The mean age of participants was 46.8 ± 13.8 years and 63.8% of participants were males. The mean plaque index and bleeding on probing (BOP) were 74% ± 21.3 and 58.1% ± 25.1, respectively. The mean maximum clinical attachment loss was 8.7 mm ±2.7, with a probing depth greater than 6 mm present in 50.4% of the sample. The median number of missing teeth was 3 (interquartile range 5-1). Pathological mobility was present in 60.6% of the patients and 78.0% had occlusion problems. Bone crest defect at the most affected site was moderate in 52.8% of cases. The ratio of bone loss to age greater than one concerned 66.1% of the sample. Generalised (81.9%), Stage IV (70.1%) and grade C (69.3%) were the most encountered diagnosis. The disease severity was associated with age (r = 0.241; P < 0.001), BOP (r = 0.230; P = 0.013) and the number of teeth with pathological mobility (r = 0.318; P < 0.001). CONCLUSION: Patients with periodontitis in this study had advanced forms of the disease and required multidisciplinary care. Clinical hindsight is necessary to improve this classification.

Connaissances et attitudes face aux péricoronarites: enquête auprès des chirurgiens-dentistes de Dakar (Sénégal)

INTRODUCTION: Une prise en charge efficace des urgences parodontales contribue au bien-être physique et psychologique du patient. L'objectif de ce travail était d'évaluer les connaissances, attitudes et pratiques des chirurgiens dentistes de Dakar face aux péricoronarites. MATÉRIELS ET MÉTHODES: Il s'est agi d'une enquête transversale descriptive réalisée auprès des chirurgiens dentistes de la région de Dakar et exerçant dans des structures privées, publiques et parapubliques. L'inclusion était basée sur la liste officielle de l'ordre national des chirurgiens dentistes du Sénégal (ONCD) de la région de Dakar de l'année 2015, et de celle du service de santé des Armées Sénégalaises. RÉSULTATS: L'échantillon comprenait 122 chirurgiens dentistes, dont 65 hommes. Le secteur public est le plus représentatif avec un pourcentage de 44,26%. Dans notre échantillon, 84,43% des dentistes prescrivent des antibiotiques et des analgésiques et 41,80% réalisent une détersion des lésions avec une boulette de coton imbibée de peroxyde d'hydrogène à 10 volumes. Cependant, 64,75% des dentistes font une excision du capuchon muqueux en urgence. CONCLUSION: La prise en charge de la péricoronarite n'est pas toujours conforme aux recommandations scientifiques actuelles. Afin de ne pas compromettre le potentiel de cicatrisation du parodonte, la formation continue des chirurgiens dentistes sénégalais devrait être un impératif éthique et légal

Impact de l'état de surface implantaire sur le risque de péri-implantite: revue systématique / Impact of implant surface characteristics on risk of peri-implantitis: a systematic review

INTRODUCTION: La mucosite et la péri-implantite sont des pathologies inflammatoires péri-implantaires d'origine infectieuse survenant autour d'implants en fonction. Les différences de conception des systèmes implantaires dans leurs caractéristiques chimiques de surface peuvent influer sur le risque potentiel de colonisation bactérienne de l'interface dent-implant .Même si plusieurs études animales suggèrent le rôle de l'état de surface dans le développement de la péri-implantite, les résultats restent contradictoires et difficilement reproductibles chez l'homme. L'objectif de cette étude était de déterminer à partir des preuves scientifiquement validées, l'impact des caractéristiques physico-chimiques de surface implantaire sur le risque de survenue d'une péri-implantite. MATÉRIELS ET MÉTHODES:Pour retrouver les articles pertinents , une stratégie de recherche couvrant la période allant du 01 Janvier 2004 au 10 Mai 2014 a été mise au point et appliquée aux bases de données MEDLINE, EMBASE, DENTISTRY & ORAL SCIENCES SOURCE et COCHRANE Library. Cette recherche électronique a été combinée à la recherche manuelle dans des revues spécialisées en parodontologie et en dentisterie implantaire. RÉSULTATS: 389 écrits sont retenus pour une inclusion dans l'étude, seuls 3 articles ont passé le filtre de l'analyse de la pertinence et des critères édictés a priori. Ces études réalisées entre 2004 et 2014 ont porté sur 705 implants posés sur 200 sujets. CONCLUSION: Les résultats ont montré que l'état de surface implantaire rugueuse ou lisse n'influence pas directement l'apparition des maladies péri-implantaires sauf en présence d'autres facteurs de risque de péri-implantite

Dental mobility is defined as an increase in the amount of movement of the dental crown under the effect of a defined force. This is a frequent reason for consultation for patients with periodontitis. This was a descriptive cross-sectional study that was carried out in the dentistry department of the Bamako Military Hospital over a period of 3 months (from January 15 to April 15, 2020). All patients who were consulted in the service and who agreed to participate in the study were included in this study. The mobility diagnosis was made using the Muhlemann index and a questionnaire was used for data collection. Dental mobility was present in 110 out of 750 patients, or 14.7%. Males represented 49%, age groups 46 and over accounted for 31.8% of cases. Pain was the most common reason for consultation with 47.3%. Muhlemann class 2 dental mobility represented the highest number with 54.6% of cases. Mobility affected more adults and women. These data illustrate the importance of implementing effective means of early management of periodontal diseases, in order to prevent the installation of disabling dental mobility for patients.

Profile of chronic and aggressive periodontitis among Senegalese.

PURPOSE: To describe the profile of chronic and aggressive periodontitis among Senegalese (West Africans) attending the Institute of Dentistry of Dakar. METHODS: A retrospective study was conducted with an inclusion period running from 2001 to 2008. The sample included 413 chronic periodontitis and 151 aggressive periodontitis cases, among them 299 males and 265 females selected from 2,274 records. A Student's independent t-test or Pearson chi-squared test was used for data analysis. RESULTS: The proportion of females with aggressive periodontitis was significantly higher than those with chronic periodontitis (64.9% vs. 40.4%, P<0.001). The aggressive periodontitis patients had an average age of 28.1±8.9 years, and had lost less than 3 teeth. Less than a third of them reported using a toothbrush. Attachment loss was as high as 8 mm and severe lesions had spread to an average of 12 teeth with maximum alveolar bone loss up to 80%. The chronic periodontitis patients had an average age of 44.9±14.0 and had lost on average less than 3 teeth. Nearly 75% used a toothbrush. Attachment loss was significantly higher and lesions were more extensive in the aggressive periodontitis. Chronic periodontitis is associated with risk factors such as smoking or diabetes mellitus in 12.8% versus 0.7% in aggressive periodontitis (P<0.001). Differences between the two groups for most clinical and radiographic parameters were statistically significant. CONCLUSIONS: The profile of aggressive periodontist is characterized by more severe lesions than chronic periodontitis, whereas tooth loss experience is similar in both forms.

Preoperative pain and medications used in emergency patients with irreversible acute pulpitis or acute apical periodontitis: a prospective comparative study.

AIMS: To determine the pain characteristics of and medications used for patients seeking emergency care for irreversible acute pulpitis (IAP) or acute apical periodontitis (AAP). METHODS: General (age, sex, weight, general health) and specific (pain intensity, localization, tooth mobility, lymphadenopathy, use of medications) information was noted in 209 patients who appeared for emergency care in 2 dental centers of Dakar with either IAP or AAP. Statistical analysis was performed with the Mann-Whitney and chi-square tests. RESULTS: The sample comprised 97 IAP patients (46.4%) and 112 AAP patients (53.6%); there were no significant differences between the 2 groups with respect to age, sex, or weight. Of the involved teeth, 62% were mandibular and 38% were maxillary. IAP patients waited 6.6 +/- 5.3 days before seeking an emergency consultation versus 5.0 +/- 3.8 days for AAP patients (P < .05). Severe pain was reported in 75% of the IAP and 76% of AAP patients (not significant). Percussion and apical palpation were painful only in AAP, in 98% and 40% of patients, respectively. Mobility and adenopathies were noted only in AAP, in 87% and 46% of patients, respectively (P < .001). Seventy-five percent of IAP patients and 80% of AAP patients used medications, mainly non-narcotic analgesics, which offered relief in 62% of IAP patients and 46% of AAP patients. CONCLUSIONS: Patients with IAP waited longer than those with AAP before seeking treatment. Self-medication offered better relief in cases of IAP than in cases of AAP. Pain to percussion and palpation, lymphadenopathies, and dental mobility were strong indicators for AAP.