RESUMO
An in vivo test using the WHO protocol (chloroquine 25 mg/kg within 3 days, trial over 7 days) was performed in 72 children in the province of Zou, Benin, in July-August 1987. The blood concentration of chloroquine was dosed before, during and after treatment by a sensitive method. This study showed a low rate of drug resistance (4.2%), even though surveys in Cotonou exhibited a high level of chloroquine resistance.
Assuntos
Cloroquina/farmacologia , Plasmodium falciparum/efeitos dos fármacos , Animais , Benin , Criança , Pré-Escolar , Cloroquina/administração & dosagem , Cloroquina/sangue , Resistência a Medicamentos , Humanos , Lactente , Malária/prevenção & controleRESUMO
In Benin, a serological study of toxoplasmosis and hydatid disease has been effected among bovine stock-breeders and the staff of the slaughter-houses in comparison with a sample of blood donors. Our results reveal the highest rate of toxoplasmosis infection (87%) among the staff of the slaughter-houses, whereas the bovine stock-breeders are the most exposed population to hydatid disease with a 9% prevalence. There is no mention of similar works in Benin in medical literature.