[An experimental evaluation of new plastic materials in the surgery of osseous tuberculosis]. / Eksperimental'naia otsenka novykh plasticheskikh materialov v khirurgii kostnogo tuberkuleza.

Experiments related with xenoplasty made in 108 rabbits are described. An original method of processing the spongy xenografts is suggested; it provides for both minimizing the immune response and for obtaining a new plastic material applicable for replacement of the postoperative osseous cavities. A complete healing of the operated bone and a close-to-norm recovery of osseous structures were ensured in experiments with animals. A similar result was obtained in experimental osseous tuberculosis after the removal of tuberculous foci. The study materials are passed over for testing in clinical practice.

[The central hemodynamic function of obese patients]. / Sostoianie tsentral'noi gemodinamiki u bol'nykh ozhireniem.

The authors substantiate the employment of radiocardiography for the examination of the cardiohemodynamics in patients with obesity of the III and IV grades. On the basis of a study of the main hemodynamic indices in patients with extreme obesity a trial is made to evaluate the pathogenesis of cardiac insufficiency in these patients.

[Determination of effective renal blood flow and the rate of glomerular filtration by sequential administration of I-131 hippuran and Yb-169 DTPA]. / Opredelenie éffektivnogo pochechnogo krovotoka i skorosti klubochkovoi fil'tratsii putem posledovatel'nogo vvedeniia 131 I-gippurana i 169 Yb-DTPK.

The authors present the results of the determination of the effective renal blood flow (ERB), the effective renal plasma flow (ERP) and the rate of glomerular filtration (GRF) by sequential administration of 131I-hippuran and 169Yb-DTPK assessing the contribution of each radionuclide in blood plasma specimens with the help of a multichannel pulse analyzer. The mean values of ERB (738.4 +/- 27.3 ml/min), ERP (391 +/- 22.4 ml/min) and GRF (128.9 ml/min) were in full accord with the literature data. The difference between GRF values calculated in the presence of 131I in plasma and after its decomposition, did not exceed 5% (6.4 +/- 1.8 ml/min), and the ratio of correlation between them was 0.948, p less than 0.01. A possibility of simultaneous determination of ERB and GRF under clinical conditions was shown.

[A comparative evaluation of methods for determining the glomerular filtration rate by 169Yb-DTPA clearance]. / Sravnitel'naia otsenka metodov opredeleniia skorosti klubochkovoi fil'tratsii po klirensu 169Yb-DTPK.

The authors present the results of comparative analysis of 7 radionuclide clearance methods for the determination of glomerular filtration rate (GFR), based on single administration of 169Yb-DTPC. A reference method was based on the determination of GFR by a curve of a decrease in plasma concentrations with subsequent biexponential analysis on a DVK-2M computer. Methods of the determination of GFR based on 2 blood drawing tests after achieving a uniform distribution of the indicator in its volume of dilution (1) and extracorporal labeling of gamma radiation by a precordial detector (2) showed the highest degree of correlation with the reference method (r = 0.918, p less than 0.001 and r = 0.920, p less than 0.001, respectively). The use of both methods based on a single-chamber model of renal clearance, led to good results, provided the measurements were to start not earlier than 1.5 h after administration of the indicator.

[Neurohumoral mechanisms regulating renal blood circulation in patients with hypertension undergoing captopril block of angiotensin-converting enzyme]. / Neirogumoral'nye mekhanizmy reguliatsii pochechnogo krovoobrashcheniia u bol'nykh gipertonicheskoi bolezn'iu pri blokade angiotenzinprevrashchaiushchego fermenta kaptoprilom.

A study was made of the effect of a single intake of captopril on the neurohumoral mechanisms of the regulation of renal circulation in 25 patients with essential hypertension (EH). Captopril induced an increase of the effective renal blood flow (ERB) and of the effective renal plasma flow along with a considerable lowering of the renal vascular resistance. No relationship was found between these changes and the time course of changes in the activity of plasma renin, aldosterone and vasopressin concentration in blood plasma. The relationship was established between the changes in the ERB and the time course of changes in baroreceptor sensitivity that significantly increased in the majority of EH patients under the effect of captopril.