RESUMO
Ependymoma is a rare central nervous system neoplasm with an even rarer morphologic variant called giant-cell ependymoma (GCE). GCE has a characteristic discrepant, malignant-like morphology but indolent behavior. We present the case of a 21-year-old female with an extra-axial GCE located in the sacral region. To date, 16 cases of sacral GCE have been reported in the literature, with 4 cases in the sacral region; however, all those cases were intra-axial. We present the first case of an extra-axial sacral GCE.
Assuntos
Ependimoma/patologia , Neoplasias de Tecidos Moles/patologia , Feminino , Humanos , Região Sacrococcígea , Adulto JovemRESUMO
BACKGROUND: Recent reviews have referred to the paranuclear dot-like staining pattern of CD99 in several neoplasms, including solid pseudopapillary tumors in the pancreas, colonic adenocarcinomas, and colonic adenomas as well as in Merkel cell carcinoma (MCC). The aim of this work was to explore the utility of CD99 paranuclear staining in the differential diagnosis of MCC. MATERIAL AND METHODS: We explore paranuclear dot-like CD99 expression in several small, round blue cell neoplasms, including neuroendocrine neoplasms, Ewing sarcomas/primitive neuroectodermal tumors (EWS/PNET), melanomas, small cell lung carcinomas (SCC), lymphoblastic lymphoma/leukemia, and rhabdomyosarcomas, in comparison with 33 cases of MCC, to determine the specificity of the paranuclear dot-like CD99 expression in MCC. RESULTS: Twenty MCC (60%) demonstrated focal expression of CD99 and of those, 14 (42.4%) showed the characteristic paranuclear dot-like expression. CD99 was also paranuclear positive in 4 of 11 (36%) SCC, in 3 of 7 (43%) EWS/PNET, in 1 of 6 (16%) lymphoblastic lymphoma/leukemia cases, in 3 of 3 (100%) rhabdomyosarcomas and all melanomas were negative for the CD99 reaction. CONCLUSION: CD99 paranuclear dot-like expression was not exclusive of the MCC compared with several neoplasms included in its differential diagnosis. This expression is not a great diagnostic aid.
Assuntos
Antígeno 12E7/biossíntese , Biomarcadores Tumorais/análise , Carcinoma de Célula de Merkel/diagnóstico , Diagnóstico Diferencial , Neoplasias Cutâneas/diagnóstico , Antígeno 12E7/análise , Carcinoma de Célula de Merkel/metabolismo , Humanos , Imuno-Histoquímica , Neoplasias Cutâneas/metabolismoAssuntos
Sarcoma Sinovial/diagnóstico , Neoplasias da Língua/diagnóstico , Adulto , Biópsia , Núcleo Celular/patologia , Citoplasma/patologia , Diagnóstico Diferencial , Humanos , Queratina-7/análise , Queratinas/análise , Masculino , Mucina-1/análise , Recidiva Local de Neoplasia/diagnóstico , Recidiva Local de Neoplasia/patologia , Proteínas Proto-Oncogênicas c-bcl-2/análise , Sarcoma Sinovial/patologia , Neoplasias da Língua/patologia , Translocação Genética/genética , Vimentina/análiseRESUMO
Con el objeto de determinar las alteraciones del sistema fagocitario fijo (SFF) en la fiebre tifoidea, se examinaron retrospectivamente las autopsias de 17 pacientes fallecidos por esta enfermedad durante los años de 1972 a 1982. Las lesiones más constantes fueron: histicitosis con hemofagocitosis en todos los órganos del SFF, microgranulomas en hígado, y bazo, y úlceras intestinales por necrosis de las placas de Peyer. Un hllazgo frecuente en esta revisión, insuficientemente informado en la literatura, es la necrosis con patrón "geográfico" que ocurre en los ganglios linfáticos mesentéricos y en la pulpa roja el bazo