RESUMO
Nasal ala, due to its characteristics, is a unique anatomical part of the body. Unfortunately, nasal ala often suffers traumas or is affected by cancers, the treatment of which can imply all-thickness amputation. In such cases, complex reconstruction is necessary to recreate both a satisfying cosmetic structure and to ensure free airflow. We present a clinical case of nasal ala major substance loss due to cancer, which was treated by use of the new Mutaf triangular flap.
Assuntos
Neoplasias Nasais/cirurgia , Rinoplastia/métodos , Retalhos Cirúrgicos , Feminino , Humanos , Pessoa de Meia-Idade , Técnicas de SuturaRESUMO
Bortezomib is a proteasome inhibitor that has proven to be a very effective treatment for multiple myeloma. There is considerable debate about the potential for reactivation of the varicella zoster virus (VZV) in patients with multiple myeloma during treatment with bortezomib. This report describes the case of a 70-year-old patient with multiple myeloma that developed bilateral herpes zoster shortly after being treated with bortezomib. Furthermore, it emphasizes the importance of using an antiviral prophylaxis with acyclovir in these patients treated with bortezomib.
Assuntos
Antineoplásicos/efeitos adversos , Ácidos Borônicos/efeitos adversos , Herpes Zoster/induzido quimicamente , Mieloma Múltiplo/tratamento farmacológico , Pirazinas/efeitos adversos , Ativação Viral/efeitos dos fármacos , Idoso , Antineoplásicos/uso terapêutico , Ácidos Borônicos/uso terapêutico , Bortezomib , Evolução Fatal , Herpes Zoster/prevenção & controle , Herpes Zoster/virologia , Herpesvirus Humano 3/fisiologia , Humanos , Masculino , Mieloma Múltiplo/virologia , Pirazinas/uso terapêuticoAssuntos
Adenocarcinoma/secundário , Adenoma de Glândula Sudorípara/patologia , Glândulas Écrinas/patologia , Neoplasias das Glândulas Sudoríparas/patologia , Adenocarcinoma/cirurgia , Adenoma de Glândula Sudorípara/cirurgia , Diagnóstico Diferencial , Glândulas Écrinas/cirurgia , Evolução Fatal , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias das Glândulas Sudoríparas/cirurgiaRESUMO
A 43-year-old woman presented with a widespread morphea, which had its onset three months before. The patient had several plaques of active, pigmented, lilac halo disease on the trunk, arms and thighs. A biopsy confirmed that the patient was suffering from morphea. Therapy with clobetasol propionate ointment 0.05% was introduced, applied twice a day, 5 days a week. After a month, the ointment failed to significantly improve the lesions. Then the patient was treated with clobetasol ointment in the morning and tacalcitol ointment 4 mcg/g in the evening. This combination resulted in marked improvement of the disease after 20 days of therapy, and we decided to stop topical steroid. After three months of treatment with topical tacalcitol once a day, the plaques regressed considerably and only a very slight pigmentation remained. Therapy was further reduced to one evening, every other day for six months more, and then was suspended completely. No side effects were observed and there was no recurrence at 24-month follow up.
