RESUMO
Cellular mechanical force plays a crucial role in numerous biological processes, including wound healing, cell development, and metastasis. To enable imaging of intercellular tension, molecular tension probes were designed, which offer a simple and efficient method for preparing Au-DNA intercellular tension probes with universal applicability. The proposed approach utilizes gold nanoparticles linked to DNA hairpins, enabling sensitive visualization of cellular force in vitro. Specifically, the designed Au-DNA intercellular tension probe includes a molecular spring flanked by a fluorophore-quencher pair, which is anchored between cells. As intercellular forces open the hairpin, the fluorophore is de-quenched, allowing for visualization of cellular force. The effectiveness of this approach was demonstrated by imaging the cellular force in living cells using the designed Au-DNA intercellular tension probe.
RESUMO
The title compound, {[Cd(CH(3)COO)(2)(C(20)H(16)N(6)S(2))]·3H(2)O}(n), exists as a one-dimensional zigzag polymer in which the Cd(II) ion shows a seven-coordinate [CdO(5)N(2)] distorted penta-gonal-bipyramidal geometry with the N atoms in axial positions and an N-Cd-N angle of 176.94â (13)°. The metal atoms are bridged by 1,2-bis-[4-(pyridin-3-yl)pyrimidin-2-ylsulfan-yl]ethane ligands, giving a polymeric chain extending along the b axis. Adjacent chains related by an inversion center are further bridged by Cd-O bonds formed between the O atom of one of the acetate ligands and the metal atom. The five Cd-O bond lengths are in the range 2.329â (3)-2.485â (3)â Å. There are π-π stacking inter-actions between the aromatic rings of adjacent polymeric chains, the centroid-centroid distances being 3.556â (3) and 3.698â (3)â Å, organizing the chains into a three-dimensional framework. This framework is additionally stabilized by extensive O-Hâ¯O and O-Hâ¯N hydrogen bonding between water mol-ecules and the ligands.
RESUMO
In the title mol-ecule, C(11)H(9)N(3)O(2)S, the pyridine and pyrimidine rings are almost parallel [dihedral angle = 6.7â (1)°]. In the crystal, adjacent mol-ecules are joined by O-Hâ¯N and C-Hâ¯O hydrogen bonds, leading to the formation of a sheet parallel to (10[Formula: see text]).
RESUMO
The mol-ecular skeleton of the title mol-ecule, C(26)H(20)N(6)S(2), adopts a cis conformation with the two arms positioned on one side of the benzene ring plane. Intra-molecular π-π inter-actions between the pyrimidine rings [centroid-centroid distance = 3.654â (2)â Å] and between the pyridine rings [centroid-centroid distance = 3.775â (2)â Å] help to set the mol-ecular conformation; the pyrimidine rings, as well as the pyridine rings, are nearly parallel, forming dihedral angles of 4.12â (14) and 2.46â (14)°, respectively.
RESUMO
In the title compound, [CdBr(2)(C(10)H(12)N(2)O)(2)(H(2)O)(2)], the Cd(II) ion is located on an inversion center and is six-coordinated by two N atoms [Cd-N = 2.377â (3)â Å] from two different 3-dimethyl-amino-1-(4-pyrid-yl)prop-2-en-1-one ligands, two O atoms [Cd-O = 2.355â (2)â Å] from two coordinated water mol-ecules and two bromide anions [Cd-Br = 2.6855â (5)â Å]. Inter-molecular O-Hâ¯O hydrogen bonds link the mol-ecules into layers parallel to the bc plane.
RESUMO
The asymmetric unit of the title compound, [Mg(H(2)O)(6)](C(9)H(6)N(3)O(3)S)(2)·4H(2)O, contains half of a centrosymmetric cation, one 4-(3-pyrid-yl)pyrimidin-2-sulfonate anion and two solvent water mol-ecules. Inter-molecular O-Hâ¯O and O-Hâ¯N hydrogen bonds link the cations, anions and water mol-ecules into a three-dimensional supra-molecular structure. The crystal packing also exhibits inter-molecular π-π inter-actions between the aromatic rings of the anions with a centroid-centroid distance of 3.604â (2)â Å.
RESUMO
In the title compound, C(21)H(18)N(6)S(2), the dihedral angles between the aromatic rings in the two 4-(4-pyrid-yl)pyrimidine residues are 23.45â (13) and 2.67â (14)°. Whereas one of the C-S-C-C torsion angles corresponds to a staggered conformation, the other is gauche.
RESUMO
The asymmetric unit of the title compound, (C(14)H(20)N(4))[Ag(CN)(2)](2), contains one-half of a centrosymmetric 2,2'-(p-phenyl-ene)bis-(1,4,5,6-tetra-hydro-pyrimidinium) (H(2)btb) cation and one [Ag(CN)(2)](-) anion. In the anions, the Ag(I) atoms adopt near linear coordination modes with the two attached cyanide groups [C-Ag-C = 173.3â (2)°]. In the crystal structure, each H(2)btb cation links four [Ag(CN)(2)](-) anions via N-Hâ¯N hydrogen bonds into a one-dimensional ribbon.
RESUMO
The asymmetric unit of the title complex, [Cu(2)(CN)(2)(C(20)H(16)N(6)S(2))](n), contains one Cu(I) cation, one cyanide ligand and half of a centrosymmetric 1,2-bis-[4-(3-pyrid-yl)pyrimidin-2-ylsulfan-yl]ethane (bppe) ligand. The Cu(I) atom displays a trigonal coordination geometry, being surrounded by one C atom from one cyanide anion and two N atoms from one cyanide and one bppe ligand. In the complex, each cyanide anion links two Cu(I) atoms in a bis-monodentate mode into a zigzag [-Cu-CN-](n) chain. Two parallel chains are linked by bppe ligands into a ladder chain.
RESUMO
The mol-ecule of the title compound, C(12)H(10)N(6), which is V-shaped due to the boat conformation of the dihydro-tetra-zine ring, has crystallographic C(2) symmetry. The dihedral angle between the planes of the two pyridine rings is 31.57â (3)°. Mol-ecules are linked by weak N-Hâ¯N and C-Hâ¯N hydrogen bonds, forming a two-dimensional polymeric structure.