Relationship between blood routine characteristics and clinical classification in 129 COVID-19 patients / 上海预防医学

Objective To investigate the characteristics of blood routine in 129 patients with COVID-19, and analyze the correlation between blood routine parameter changes and clinical classification. Methods A total of 129 COVID-19 patients were recruited and their blood samples were collected at the beginning and the end of treatment.The neutrophil-to-lymphocyte ratio(NLR), platelet-to-lymphocyte ratio(PLR), lymphocyte-to-monocyte ratio(LMR) and C-reactive protein(CRP) were determined and used to calculate Δ NLR, Δ PLR, Δ LMR.The differences in these parameters were compared between the non-severe group (93 cases) and the severe group (36 cases).In addition, the relationship between the changes in blood routine test result and the prognosis of patients was determined. Results The average age of 129 patients was 46.9±17.4 years old, and the ratio of male to female was 1.2 ∶ 1.Thirty-five (35) cases (27.1%) had leucopenia (< 4×109/L) and 59 cases (45.7%) had lymphopenia (< 1.1×109/L).There were statistically significant differences in age, treatment days, blood routine indexes between these two groups.In all the patients, the differences between before and after treatment were statistically significant in the following: leukocyte number, neutrophil cell percentage, lymphocyte number, lymphocyte percentage, monocyte number, monocyte percentage.The differences in RBC, HGB, CRP, and NLR between the two groups before and after treatment were also statistically significant (P < 0.05). Conclusion The older COVID-19 patients have lower number of lymphocytes, higher NLR and PLR, lower LMR and higher CRP.They have a higher risk of progressing to severe disease.After treatment, there is an increase in the number of granulocytes, especially the number of lymphocytes, while a decrease in CRP and NLR.The change of lymphocyte count, NLR and CRP levels can predict the risk of severe COVID-19 and evaluate the therapeutic effect.

Advances in research of pharmacological effects and formulation studies of linalool / 中国中药杂志

Linalool, as a major volatile compound, is widely distributed in natural plant essential oil. In addition, it can also be artificially synthesized. Linalool is used frequently as an important ingredient of perfumes and household detergents. It is still employed in food flavor and industries. Besides, linalool has some positive effect on healthcare. Many studies have showed that linalool exhibited a variety of pharmacological activities, including analgesic, anxiolytic, sedative, anti-inflammatory, anti-tumor and anti-bacterial effects. Therefore, linalool will be a promising agent for clinical application. This article reviews the pharmacological effects and formulation studies of linalool so as to provide a theoretical basis for its further development and utilization.

Investigation of life quality of severe burn patients at rehabilitation stage and analysis of the related influential factors / 中华烧伤杂志

<p><b>OBJECTIVE</b>To investigate the life quality in severe burn patients at rehabilitation stage and analysis of related influential factors.</p><p><b>METHODS</b>Social support rating scale, general quality of life inventory and retrospective investigation were used to evaluate the life quality of 96 severe burn patients (E group, age: over 16 years) at rehabilitation stage,and 96 healthy people were enrolled into our study as control (C group). The relationship between the life quality and sex, age, education background, occupation, post burn time, burn causes, burn depth, total burn surface area, length of hospitalization, medical cost, return to work was respectively analyzed.</p><p><b>RESULTS</b>There was obvious difference in total score of the life quality between two groups (53 +/- 12 in E group vs. 63 +/- 10 in C group, P < 0.01). There were no obvious difference in life quality among patients with different sex, age, education, burn causes, length of hospitalization and medical expenditure( P > 0.05). The score of social function dimension and material function dimension in married patients were higher than that in singles. The life quality had positive correlation with social support score, return to work, post burn time, and occupation. There were negative correlation between deep burn area and life quality.</p><p><b>CONCLUSION</b>The life quality level of severe burn patients at rehabilitation stage is low. Social support, return to work, duration after burn, occupation and deep burn area are correlating factors affecting life quality. Rehabilitation;</p>