Retailing Strategies for Power Retailers with a Generator Background Considering Energy Conservation Services under the Internet of Things.

Facing the electricity market environment, in which the traditional power grid is transformed into a smart grid, power retailers with a generator background are designing new business models of cold-heat-electricity multi-energy supply based on the Internet of Things data collection, interconnection, computing and other technical supports. On the other hand, through internet of things real-time monitoring technology, the necessity of setting up energy security for power retailers is explored to enhance the control's ability to deal with the risks of electricity sales. Firstly, based on internet of things data analysis, retail strategies such as cooling-heat-electricity multi-energy packages, desulphurization and carbon emissions and energy conservation are designed. Then, a revenue cost measurement model based on the generator background of the power retailers is established. A source of data for the expansion of power retailers and the proliferation of load users is provided through the real-time monitoring of new business models that consider the operation of energy conservation on the supply and use side. Finally, an analysis based on the detection of operation under the scenarios constructed in the example of coal price market fluctuations and proliferation stagnation of user-side packages is conducted. It is verified that the power retailers with a generator background can effectively weaken the adverse impact of upward fluctuations in the coal price market in the peak season of energy consumption on the cost of power retailers by setting energy conservation. At the same time, the diffusion of a new business model in the user side is improved, and the revenue source of power retailers is further expanded. Therefore, taking energy conservation as an important innovation technique of retail strategy can enhance the market competitiveness and risk control ability of power retailers.

Multi-Time Scale Trading Simulation of Source Grid Load Storage Based on Continuous Trading Mechanism for China.

The proportion of new energy in power systems is increasing yearly. How to deal with the adverse impact of new energy output uncertainty on its participation in trading from the mechanism level is an urgent problem in China that must be solved. A source grid load storage (SGLS) continuous trading mechanism and a multi-time scale trading simulation method are proposed which meet the needs of Chinese new energy consumption and satisfies the trading needs of Chinese power market players. Firstly, the connection mechanism of mid-long term, day-ahead, and intra-day SGLS interactive trading is established, and the meaning and ways of continuous development are defined. Secondly, the clearing model of SGLS trading based on the continuous trading mechanism is established to provide mathematical models and strategic methods for various resources to participate in SGLS trading. Then, the multi-time scale trading simulation of SGLS based on the continuous trading mechanism is carried out to obtain the trading strategies of different trading subjects. The example results show that compared with the trading mechanism based on deviation assessment, the one-day trading cost is reduced by 4.20% and the consumption rate of new energy is increased by 6.53%. It can be seen that the mid-long term-day-ahead-day SGLS interactive trading connection mechanism has advantages in reducing trading costs and improving the consumption rate of new energy. It can flexibly deal with the trading scenario of domestic new energy consumption and new energy reverse peak shaving, which has an effect on the adverse impact of trading and operation deviation caused by source load uncertainty on trading.

The pro-tumorigenic activity of p38γ overexpression in nasopharyngeal carcinoma.

It is urgent to identify and validate biomarkers for early diagnosis and efficient treatment of nasopharyngeal carcinoma (NPC). Recent studies have proposed p38 gamma (p38γ) as a cyclin-dependent kinase (CDK)-like kinase that phosphorylates retinoblastoma (Rb) to promote cyclins expression and tumorigenesis. Here the Gene Expression Profiling Interactive Analysis (GEPIA) database and results from the local NPC tissues demonstrate that p38γ is significantly upregulated in NPC tissues, correlating with poor overall survival. Furthermore, p38γ mRNA and protein expression is elevated in established NPC cell lines (CNE-1 HONE-1 and CNE-2) and primary human NPC cells, but low expression detected in human nasal epithelial cells. In established and primary NPC cells, p38γ depletion, using the shRNA strategy or the CRISPR/Cas9 gene-editing method, largely inhibited cell growth, proliferation and migration, and induced significant apoptosis activation. Contrarily, ectopic p38γ overexpression exerted opposite activity and promoted NPC cell proliferation and migration. Retinoblastoma (Rb) phosphorylation and cyclin E1/A expression were decreased in NPC cells with p38γ silencing or knockout, but increased after p38γ overexpression. Moreover, mitochondrial subcellular p38γ localization was detected in NPC cells. Significantly, p38γ depletion disrupted mitochondrial functions, causing mitochondrial depolarization, reactive oxygen species production, oxidative injury and ATP depletion in NPC cells. In vivo, intratumoral injection of adeno-associated virus-packed p38γ shRNA potently inhibited primary human NPC xenograft growth in nude mice. In p38γ shRNA virus-injected NPC xenograft tissues, p38γ expression, Rb phosphorylation, cyclin E1/A expression and ATP levels were dramatically decreased. Taken together, we conclude that p38γ overexpression is required for NPC cell growth, acting as a promising therapeutic target of NPC.

Heat Balance Calculation and Energy Efficiency Analysis for Building Clusters Based on Psychrometric Chart.

How to perform accurate calculation of heat balance and quantitative analysis of energy efficiency for building clusters is an urgent problem to be solved to reduce building energy consumption and improve energy utilization efficiency. This article proposes a method for the heat balance calculation and energy efficiency analysis of building clusters based on enthalpy and humidity diagrams and applies it to the energy management of building clusters containing primary return air systems and heating pipe networks. Firstly, the basic structure and energy management principle of building clusters with a primary return air system and a heating pipe network were given, and the heat balance calculation and energy efficiency analysis method based on i-d diagram was proposed to realize the accurate calculation of heat load and the quantification of energy utilization. Secondly, the energy management model of the building cluster with a primary return air system and a heating pipe network was established to efficiently manage the indoor temperature and the heating schedule of ASHP, HN and HI. Finally, the proposed method was validated by calculation examples, and the results showed that the proposed method is beneficial for improving the energy economy and energy efficiency of building clusters.

ZBTB24 regulates the apoptosis of human T cells via CDCA7/TRAIL-receptor axis.

Mutations in ZBTB24 and CDCA7 cause the Immunodeficiency, Centromeric Instability and Facial Anomalies syndrome type 2 and 3 (ICF2/3), respectively. Most ICF2 patients carry ZBTB24 nonsense mutations and are thus ZBTB24-deficient. Although the immune deficiency in ICF2 patients is primarily regarded as a B-cell defect due to the greatly reduced serum antibodies and circulating memory B cells, the reduced expansions of PBMCs stimulated by mitogens or recall antigens suggest a T-cell defect in these patients as well. However, the molecular mechanisms behind this T-cell dysfunction remain unknown. In the present study, we demonstrated that ZBTB24-deficiency significantly represses the proliferation of human T cells by promoting TRAIL-induced cell death. Downregulation of ZBTB24 in both Jurkat and human primary T cells upregulates the expression of TRAIL and/or its death receptors (TRAIL-R1/2), and induces significant amount of cells to undergo apoptosis. The profound survival defects of ZBTB24-deficient cells are largely reversed by blocking TRAIL/TRAIL-R interactions with exogenous recombinant TRAIL-R2. Moreover, ZBTB24-downregulation reduces the expression of CDCA7, and knockdown of the latter in human T cells results in a phenotype resembling that caused by ZBTB24-depletion. Functionally, overexpression of CDCA7 abrogates the increased apoptosis in ZBTB24-depleted Jurkat T cells. Together, these data indicated that ZBTB24 regulates human T-cell apoptosis via CDCA7/TRAIL-R axis. Our study thus not only provides a molecular explanation for the T-cell defects in ZBTB24-deficient ICF2 patients, but also highlights a convergence between ZBTB24 and CDCA7, the two ICF genes, in modulating the functions of T cells.

[Three cases of eosinophilichyperplastic lymphogranuloma in children's parotid area].

From March 2009 to October 2009, three pediatric patients with parotid tumor were cured. Preoperative physical examination showed regional swelling in parotid area, the surface skin was in moderate reddish purple, the border was vague, and the swelling was inactive. The patients' IgE were significantly increased. B ultrasound examination demonstrated the focus was an isoecho with ringlike dark band around, which was concluded as bull's-eye sign. Magnetic resonance imaging (MRI) examination indicated a cystic mass between the skin and parotid. Preoperative diagnosis was eosinophilichyperplastic lymphogranuloma (Kimura's disease) and the granuloma was excised by operation. Pathological examination revealed the capillary vessel hyperplasia in local tissue with a plenty of eosinophils and lymphocytes infiltrating. The disease was confirmed. Although the disease is rare, the diagnosis still could be made by preoperative physical examination, laboratory and imaging examinations.