[Integrins and prolidase activity in uterine leiomyoma during tumor growth]. / Integryny a aktywnosc prolidazy w róznych okresach wzrostu miesniaków macicy.

Collagens and proteoglycans are the main components of connective tissue. Prolidase plays an important role in the balance between collagen biosynthesis and degradation and its activity reflects the rate of collage turn-over. The activity of this enzyme is known to be regulated by interaction of collagen with beta 1 integrin receptor. It was found that increase in the uterine leiomyoma weight is accompanied by increased beta 1 integrin receptor expression and prolidase activity. It suggests that collagen turn-over is altered in uterine leiomyoma growth.

[Extracellular matrix components in ovarian tumors]. / Charakterystyka elementów lacznotkankowych w guzach jajnika.

This report describes the collagen, glycosaminoglycans and elastin--composition of ovarian tumours. Rearrangement of extracellular matrix in ovarian tumour has been found. There was an increase of total collagen content in comparison to control. Type I collagen was found to be predominant in both tissues. Both tissues, normal and neoplastic one, contain all known glycosaminoglycans. Among them dermatan sulphate was found to be the most abundant. In ovarian tumour an increase of this glycosaminoglycan content was observed.

Accumulation of collagen in ovarian benign tumours.

Extracellular matrix components of benign ovarian tumours (cystadenoma, adenofibroma, cystadenofibroma) were analysed. The investigated tumours contained twice as much collagen than control ovarian tissues. Significant alterations in mutual quantitative relationships between collagens of various types were observed. The proportion of type I collagen decreased and that of type III collagen increased. The accumulation of collagen was accompanied by a reduction in sulphated glycosaminoglycan content whereas the amount of hyaluronic acid was not changed. Dermatan sulphate was the most abundant glycosaminoglycan component. It is suggested that the accumulation of collagen (natural barrier to the migration of tumour cells) and underexpression of glycosaminoglycans/proteoglycans (binding some growth factors and interleukins) may exert an inhibitory effect on tumour growth.

[Extracellular matrix components in leiomyosarcoma]. / Elementy lacznotkankowe w nowotworach macicy (leiomyosarcoma).

This report describes the glycosaminoglycans, collagen and elastin--composition of leiomyosarcoma. Studies were performed on leiomyosarcoma removed during surgery. The material was taken from 7 patients. Rearrangement of extracellular matrix in leiomyosarcoma has been found. There was an increase of total collagen content in comparison to control uterus. In both tissues type I collagen was found to be the predominant one. Both tissues, normal and neoplastic contain all known glycosaminoglycans types. Among them heparan sulphate was found to be the most abundant. A slight decrease in the content of this glycosaminoglycan was observed in leiomyosarcoma. A possible role of these alterations in tumour biology is discussed.

[Glycosaminoglycans in uterine leiomyoma]. / Glikozoaminoglikany w miesniakach macicy.

During development of leiomyoma, a reorganisation of main components of connective tissue has been found. All types of glycosaminoglycans are present in this tissue. Among them the heparan sulphate is the most abundant. Its content was found to increase with uterine myoma weight. It is worthy of note that the increase of keratan sulphate is observed in big leiomyoma.

Extracellular matrix components in uterine leiomyoma and their alteration during the tumour growth.

It was found that both normal human myometrium and uterine leiomyoma contain several glycosaminoglycans. In contrast to many normal and tumour tissues the amount of hyaluronic acid is very low and the proportional amount of sulphated glycosaminoglycans is distinctly higher. It is of interest that heparan sulphate is the major glycosaminoglycan component both in normal myometrium, and in leiomyoma. The amount of hyaluronic acid in myometrium and in the leiomyoma is very low. No significant change in hyaluronate content was observed during the tumour growth. In contrast to that the amount of some sulphated glycosaminoglycans (heparan sulphate, keratan sulphate, chondroitin sulphates and heparin) distinctly increased. It is suggested that some of the GAGs participate in the creation of a storage depot for biologically active molecules (growth factors, enzymes) which are thereby stabilized and protected. Hydrolytic degradation of some GAGs may result in the release of some cytokines which may promote the tumour growth and stimulate collagen biosynthesis by tumour cells.

[Results of surgical treatment of stress urinary incontinence in women]. / Wyniki leczenia operacyjnego wysilkowego nietrzymania moczu u kobiet.

Post-operation results of stress urinary incontinence treatment have been assessed and subjected to statistical analysis in 667 patients. The elaboration of the results was based on case history data, inquiries and control ambulatory examinations. Diagnostic procedures included sphincterometry, cystometry, cystoscopy, cystography and provocation test like coughing. Vaginal and urine biocenosis was always assessed microbiologically. The Marshall-Marchetti operation as modified by Durfée and Burch was made within the space of Retzius. Complementary procedure consisted in suturing levator ani muscles after previous bilateral opening of pararectal space within perineum. Third pair of sutures was placed according to the authors' own modification during the Durfée operations. The results of surgical treatment of SUI performed by the authors do not differ in principle from those reported by others. A small number of relapses the authors ascribe to local and systemic processes of aging which diminish the effectiveness and the value of previously made correction of urethra and of the bladder bottom topography.

[Regressive changes in the placenta in early pregnancy in women with primary arterial hypertension]. / Zmiany wsteczne lozyska w ciazy wczesnej u kobiet z pierwotnym nadcisnieniem tetniczym.

Morphological methods, in particular histochemical technique of secondary fluorescence according to Bertalanffy were used for the assessment of regressive changes of placenta. In women with primary arterial hypertension during early pregnancy fibrinoid masses in decidua, chorion, anchoring willi, villous plate, basal plate, villous trunks and terminal villi appear. These changes are followed from one side, by an atrophy of the blood vessels and connective tissue cells, and from the other, there increases the number of decidua giant cells, as well as of syncytium and cytotrophoblast. The areas of impaired blood supply contain giant cells and intervening foam cells. These cells according to the authors can be the forms of regressive changes exhibiting relative biological activity influencing trophic status of the placenta. Possible importance of the fibrinoid masses for the immunology of pregnancy which is developing under maternal morbid conditions has been discussed.