RESUMO
Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare and aggressive myeloid malignancy associated with a poor prognosis. Although allogeneic hematopoietic stem cell transplantation (allo-HSCT) has emerged as a potential treatment strategy for BPDCN, standardized conditioning regimens remain lacking. In this manuscript, we present two cases of BPDCN that were treated with a thiotepa-busulfan-fludarabine (TBF)-based conditioning regimen prior to allo-HSCT. Both cases demonstrated complete remission post-transplantation, sustained donor chimerism, and remission maintenance, suggesting the potential efficacy of the TBF conditioning regimen for BPDCN transplantation. Given the small sample size in our study, we emphasize caution and advocate for larger studies to confirm the efficacy of TBF in the treatment of BPDCN.
Assuntos
Bussulfano , Células Dendríticas , Transplante de Células-Tronco Hematopoéticas , Tiotepa , Condicionamento Pré-Transplante , Vidarabina , Humanos , Vidarabina/análogos & derivados , Vidarabina/administração & dosagem , Vidarabina/uso terapêutico , Condicionamento Pré-Transplante/métodos , Células Dendríticas/patologia , Tiotepa/administração & dosagem , Tiotepa/uso terapêutico , Masculino , Bussulfano/administração & dosagem , Bussulfano/uso terapêutico , Pessoa de Meia-Idade , Neoplasias Hematológicas/terapia , Neoplasias Hematológicas/patologia , Feminino , Transplante Homólogo , Adulto , Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , AloenxertosAssuntos
Insuficiência Cardíaca , Neoplasias Cardíacas , Linfoma Difuso de Grandes Células B , Neoplasias do Timo , Humanos , Insuficiência Cardíaca/etiologia , Neoplasias do Timo/complicações , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/diagnóstico por imagem , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Neoplasias Cardíacas/diagnóstico por imagem , Neoplasias Cardíacas/tratamento farmacológicoRESUMO
Zr-N-codoped TiO2 nano-photocatalyst was prepared through sol-gel method using ammonia water and zirconium nitrate as the source of N and Zr, respectively. The resulting materials were characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), X-ray photoelectron spectroscopy (XPS) and ultraviolet-visible diffuse reflectance spectroscopy (UV-vis DRS). XRD results showed that codoping with Zr and N elements could greatly inhibit the phase transformation of TiO2 from anatase to rutile. XPS analysis indicated that Zr4+ was incorporated into the lattice of TiO2 through substituting titanium atoms. Meanwhile, N was also incorporated into the lattice of TiO2 through substituting oxygen atoms and existed in the form of N-Ti-O. DRS revealed that the light absorption edge of Zr-N-TiO2 was significantly red-shifted to visible region, leading to a narrower band gap and higher visible photocatalytic activity. The enhanced visible activity was attributed to the well anatase crystallite, intense light absorbance in visible region and narrow band gap.
