1.
Bioorg Med Chem Lett
; 13(13): 2195-8, 2003 Jul 07.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12798333
RESUMO
Novel tricyclic benzazepine derivatives were synthesized as arginine vasopressin (AVP) antagonists. Several tricyclic compounds showed potent antagonistic activity in rat AVP receptors V(1a) and V(2). Derivatives containing pyrrolo-tricyclic amines, 13i-k, 30, and 31 also showed selectivity for the V(2) receptor.
