RESUMO
BACKGROUND: The literature on thyrotoxicosis caused by excessive ingestion of exogenous thyroid hormone is limited, and most cases reported have involved pediatric clinical studies. CASE SUMMARY: A 21-year-old woman initially presented with palpitation and chest tightness after an overdose of levothyroxine (10 mg). The patient transiently lost consciousness and developed atrial fibrillation during hospitalization. We used propylthiouracil to decrease the peripheral conversion of T4 to T3 and inhibit the synthesis of endogenous thyroxine, propranolol to control heart rate, hydrocortisone to correct severe thyrotoxicosis, and hemoperfusion to increase levothyroxine clearance. The patient recovered and was discharged. CONCLUSION: For patients with thyrotoxicosis after taking excess levothyroxine, it is critical to monitor vital signs and initiate effective treatment.
RESUMO
Aluminium (Al) toxicity is a major limiting factor for plant productivity in acidic soils. Calcium (Ca) is an essential element and participates in various physiological responses to environmental stress. Here, the aim of this work was to study the role of exogenous Ca in alleviating Al toxicity in Arabidopsis thaliana. For that we used the methods of physiology and proteomics. Results showed that Ca alleviated Al-induced growth inhibition and decreased Al accumulation. Proteomic analyses showed that 75 differentially expressed protein spots, including those related to organic acid metabolism, cell wall components, cellular transport, signal transduction and antioxidant activity, transcription and protein metabolism were identified during the response of Arabidopsis to Ca alleviated Al toxicity. Ca regulated tricarboxylic acid (TCA) cycle-related protein abundances and affected organic acid concentrations and related enzyme activities under Al stress. Vacuolar and mitochondrion adenosine triphosphate (ATP) synthase, and cell wall component-related proteins played important roles in Ca-alleviated Al toxicity. Ethylene-insensitive 3 (EIN3) participated in Ca-alleviated Al toxicity. Glutathione S-transferase (GST6) and glutathione S-transferase tau 19 (ATGSTU19) were associated with antioxidant activities induced by Ca under Al stress. Our results may contribute to an understanding of the functional mechanism by which Ca alleviates Al stress in plants. SIGNIFICANT: Our results elucidated how Ca alleviate the effects of Al toxicity on the inhibition of plant growth and Al accumulation in plants using the proteomics and physiological methods, which may contribute to a better understanding of the molecular mechanism of Ca alleviation Al stress in plants.