1.
J Chromatogr
; 496(2): 478-84, 1989 Nov 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2613850
2.
J Chromatogr
; 489(2): 452-8, 1989 Apr 14.
Artigo
em Inglês
| MEDLINE
| ID: mdl-2753969
3.
J Pharm Sci
; 66(11): 1615-8, 1977 Nov.
Artigo
em Inglês
| MEDLINE
| ID: mdl-915740
RESUMO
A high-pressure liquid chromatographic method suitable for determining plasma metoclopramide levels at normal (10-20 mg) doses is described. Eight metabolites as well as metclopramide were isolated and identified in rat, dog. and human urine. The only common metabolite in these species is 2-[(4-amino-5-chloro-2-methoxybenzoyl)-amino] acetic acid. N-Deethylation is a major pathway for metoclopramide metabolism in the lower animals but not in humans. Metoclopramide is excreted mainly unchanged or as its conjugates by humans.
Assuntos
Metoclopramida/metabolismo , Animais , Biotransformação , Cromatografia Líquida de Alta Pressão , Cromatografia em Camada Fina , Cães , Feminino , Humanos , Masculino , Espectrometria de Massas , Ratos
4.
J Pharm Sci
; 63(3): 446-8, 1974 Mar.
Artigo
em Inglês
| MEDLINE
| ID: mdl-4820382