Glycyrrhizinic Acid as an Antiviral and Anticancer Agent in the Treatment of Human Papillomavirus.

Human papillomavirus (HPV), like any other virus, needs to penetrate the host cell and make use of its machinery to replicate. From there, HPV infection can be asymptomatic or lead to benign and premalignant lesions or even different types of cancer. HPV oncogenesis is due to the ability of the viral oncoproteins E6 and E7 to alter the control mechanisms for the growth and proliferation of host cell. Therefore, the use of agents with the ability to control these processes is essential in the search for effective treatments against HPV infections. Glycyrrhizinic acid (Gly), the active ingredient in liquorice, has been shown in numerous preclinical studies to have an antiviral and anticancer activity, reducing the expression of E6 and E7 and inducing apoptosis in cervical cancer cells. In addition, it also has antioxidant, anti-inflammatory, immunomodulatory or re-epithelializing properties that can be useful in HPV infections. This review includes the different antiviral and anticancer mechanisms described for Gly, as well as the clinical studies carried out that position it as a potential therapeutic strategy against HPV both through its topical application and by oral administration.

Luxación aislada del escafoides / Luxation isolée du scaphoïde / Isolated dislocation of the scaphoid

El funcionamiento armónico de la mano desempeña un papel fundamental para el desarrollo de la vida del hombre. En la sociedad moderna las lesiones a este nivel, a pesar de su baja incidencia, son causa frecuente de discapacidad funcional. Se presenta un paciente blanco, masculino, de 38 años, atendido por el Servicio de Urgencias tras un trauma de alta energía con hiperflexión forzada de la muñeca. Se diagnostica una luxación aislada del escafoides que se reduce bajo anestesia con ayuda del intensificador de imágenes. Se inmoviliza por 6 semanas con férula braquial, tomando primer dedo, y posteriormente comienza el proceso de rehabilitación. El tratamiento oportuno y adecuado de la afección mencionada es indispensable para obtener los mejores resultados en la recuperación funcional(AU)

The orderly functioning of the hand plays a key role for the development of human life. In modern society injuries at this level are a frequent cause of functional disability, despite its low incidence. A case of a white, male patient, 38, attended by the emergency department after a high-energy trauma with forced hyperflexion of the wrist is presented here. An isolated dislocation of the scaphoid is diagnosed and it is reduced under anesthesia using the image intensifier. It is immobilized for 6 weeks with brachial splint, taking first finger, and then the rehabilitation process begins. The timely and proper treatment of this condition is essential to obtain the best results in functional recovery(AU)

Le fonctionnement harmonieux de la main joue en rôle essentiel dans le développement de la vie de l'homme. Dans la société moderne, les lésions au niveau de la main, malgré leur faible incidence, sont la cause la plus fréquente d'invalidité fonctionnelle. Un patient, blanc, âgé de 38 ans, traité au service d'urgence dû à un traumatisme à haute énergie qui a été provoqué par une hyperflexion forcée du poignet, est présenté. Une luxation isolée du scaphoïde, corrigée sous anesthésie à l'aide d'un intensificateur d'images, est diagnostiquée. Tout d'abord, le poignet a été immobilisé pendant 6 semaines par une attelle ante-brachiale de poignet avec trou pour le pouce, et puis la rééducation a commencé. Le traitement précoce et approprié de cette affection est indispensable pour obtenir les meilleurs résultats dans la récupération de la fonction(AU)

Luxación aislada del escafoides / Isolated Dislocation of the Scaphoid

El funcionamiento armónico de la mano desempeña un papel fundamental para el desarrollo de la vida del hombre. En la sociedad moderna las lesiones a este nivel, a pesar de su baja incidencia, son causa frecuente de discapacidad funcional. Se presenta un paciente blanco, masculino, de 38 años, atendido por el Servicio de Urgencias tras un trauma de alta energía con hiperflexión forzada de la muñeca. Se diagnostica una luxación aislada del escafoides que se reduce bajo anestesia con ayuda del intensificador de imágenes. Se inmoviliza por 6 semanas con férula braquial, tomando primer dedo, y posteriormente comienza el proceso de rehabilitación. El tratamiento oportuno y adecuado de la afección mencionada es indispensable para obtener los mejores resultados en la recuperación funcional(AU)

The orderly functioning of the hand plays a key role for the development of human life. In modern society injuries at this level are a frequent cause of functional disability, despite its low incidence. A case of a white, male patient, 38, attended by the emergency department after a high-energy trauma with forced hyperflexion of the wrist is presented here. An isolated dislocation of the scaphoid is diagnosed and it is reduced under anesthesia using the image intensifier. It is immobilized for 6 weeks with brachial splint, taking first finger, and then the rehabilitation process begins. The timely and proper treatment of this condition is essential to obtain the best results in functional recovery.

Psychometric attributes of the Cervantes short-form questionnaire for measuring health-related quality of life in menopausal women.

OBJECTIVE: To analyse the psychometric properties of the Cervantes scale short-form (SF) in the peri- and post-menopausal periods. METHODS: Outpatients women 45-65 years with menstrual problems associated with the climacteric syndrome were analysed. Original and SF versions of the Cervantes scale were administered along with the EuroQol-5D (EQ-5D) and work productivity and activity impairment questionnaire (WPAI) scales. Conceptual model, burden of administration, feasibility, reliability, criteria validity and construct validity were assessed. RESULTS: 317 women [55.7±5.3 years (mean±standard deviation)] were recruited: 75.4% were post- and 22.3% were peri-menopausal. The Cervantes-SF was completed in 2.5±1.6min, and 86% answered all items. Cronbach's α was 0.820, and ranged from 0.510 (Aging) to 0.918 (Vasomotor Symptoms) for individual dimensions. The scale structure matched the structure of the original version, χ(2)/(degrees of freedom)=3.6, Comparative Fit Index=0.848, Tucker-Lewis Index=0.850, and root mean square error of approximation=0.099, although differences were found between sexual activity statuses. Criteria validity was good (r=0.890), concurrent validity was congruent with a priori hypothesis using either the EQ-5D or the WPAI scales. The scale discriminated significantly the severity of both vasomotor and genital climacteric associated symptoms. CONCLUSION: The Cervantes-SF has shown good psychometric properties for measuring Health related quality of life in peri- and post-menopausal women who regularly attended gynaecology clinics in Spain.

Luxación aislada del escafoides / Isolated dislocation of the scaphoid

El funcionamiento armónico de la mano desempeña un papel fundamental para el desarrollo de la vida del hombre. En la sociedad moderna las lesiones a este nivel, a pesar de su baja incidencia, son causa frecuente de discapacidad funcional. Se presenta un paciente de piel blanca, masculino, de 38 años, atendido tras un trauma de alta energía con hiperflexión forzada de la muñeca secundaria al mismo. Se diagnosticó una luxación aislada del escafoides que se reduce bajo anestesia con ayuda del intensificador de imágenes. Se inmoviliza con férula braquial, tomando primer dedo, por seis semanas y posteriormente comienza proceso de rehabilitación. El tratamiento oportuno y adecuado de la patología mencionada es indispensable para obtener los mejores resultados, en la recuperación funcional.

The smooth functioning of the hand plays a key role for the development of human life. In modern society, injuries at this level, despite their low incidence, are a frequent cause of disability. A white male patient, aged 38 is presented here. He was assisted after a high-energy trauma, forced high wrist hyperflexion. An isolated dislocation of the scaphoid was diagnosed, which is reduced under anesthesia using the image intensifier. It is immobilized with brachial splint, taking first finger for six weeks and then rehabilitation process. Timely and adequate treatment of this disease is essential to get the best results in functional recovery.

Luxación aislada del escafoides / Isolated dislocation of the scaphoid

El funcionamiento armónico de la mano desempeña un papel fundamental para el desarrollo de la vida del hombre. En la sociedad moderna las lesiones a este nivel, a pesar de su baja incidencia, son causa frecuente de discapacidad funcional. Se presenta un paciente de piel blanca, masculino, de 38 años, atendido tras un trauma de alta energía con hiperflexión forzada de la muñeca secundaria al mismo. Se diagnosticó una luxación aislada del escafoides que se reduce bajo anestesia con ayuda del intensificador de imágenes. Se inmoviliza con férula braquial, tomando primer dedo, por seis semanas y posteriormente comienza proceso de rehabilitación. El tratamiento oportuno y adecuado de la patología mencionada es indispensable para obtener los mejores resultados, en la recuperación funcional(AU)

The smooth functioning of the hand plays a key role for the development of human life. In modern society, injuries at this level, despite their low incidence, are a frequent cause of disability. A white male patient, aged 38 is presented here. He was assisted after a high-energy trauma, forced high wrist hyperflexion. An isolated dislocation of the scaphoid was diagnosed, which is reduced under anesthesia using the image intensifier. It is immobilized with brachial splint, taking first finger for six weeks and then rehabilitation process. Timely and adequate treatment of this disease is essential to get the best results in functional recovery(AU)