RESUMO
We report on 2 patients (mother and daughter) suffering from systemic sclerosis (SP) which could be proved clinically, histologically, and immunologically. Investigations on the mother revealed the following HLA antigens: A-2, A-24, B-8, B-12, C-2, and C-4; regarding the daughter we found A-2, A-24, B-12, B-18, DR-1, and DR-2.
Assuntos
Esclerodermia Localizada/genética , Adulto , Biópsia , Feminino , Humanos , Pessoa de Meia-Idade , Esclerodermia Localizada/patologia , Pele/patologiaRESUMO
We report on two patients (father and son) suffering from familial Lupus erythematosus chronicus discoides which could be proved clinically, histologically, and immunologically. Investigations on HLA revealed A-11, A-24, and B-35 for the father and A-24, B-13, and C-4 for the son.
Assuntos
Dermatoses Faciais/genética , Lúpus Eritematoso Discoide/genética , Adulto , Criança , Dermatoses Faciais/patologia , Imunofluorescência , Antígenos HLA/genética , Humanos , Imunoglobulina G/metabolismo , Imunoglobulina M/metabolismo , Lúpus Eritematoso Discoide/patologia , Pele/patologiaAssuntos
DNA/biossíntese , Melanócitos/metabolismo , Vitiligo/metabolismo , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Pele/patologia , Vitiligo/patologiaRESUMO
The number and morphological changes of the mast cells were studied in the skin of three groups white rats. The first group was treated subcutaneously with 5 mg/kg body weight chloroquine diphosphate for twenty days, the second group was treated with saline; the third group was not treated at all. An absolute increase of the number of mast cells in the animals treated with chloroquine diphosphate was established. It was assumed the increase of the mast cells is connected with the activation of the histidine-decarboxylase and the rise of the histamine level in the site of chloroquine diphosphate application.
