Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/uso terapêutico , Hepatomegalia/diagnóstico , Neoplasias Hepáticas/diagnóstico , Fígado/patologia , Linfoma Difuso de Grandes Células B/diagnóstico , Adulto , Biópsia , Medula Óssea/patologia , Ciclofosfamida/uso terapêutico , Doxorrubicina/uso terapêutico , Hepatomegalia/tratamento farmacológico , Hepatomegalia/etiologia , Humanos , Fígado/diagnóstico por imagem , Neoplasias Hepáticas/complicações , Neoplasias Hepáticas/tratamento farmacológico , Neoplasias Hepáticas/patologia , Linfoma Difuso de Grandes Células B/complicações , Linfoma Difuso de Grandes Células B/tratamento farmacológico , Linfoma Difuso de Grandes Células B/patologia , Masculino , Prednisona/uso terapêutico , Rituximab/uso terapêutico , Tomografia Computadorizada por Raios X , Resultado do Tratamento , Carga Tumoral , Vincristina/uso terapêuticoRESUMO
Haemophilia is a common cause of genetically inherited bleeding disorders. Pseudotumours occur in 1-2 % of persons with severe forms of haemophilia. These are a result of repeated haemorrhage into soft tissues, subperiosteum or a site of bone fracture with inadequate resorption of the extravasated blood. There are a number of therapeutic alternatives for this dangerous condition: surgical removal, percutaneous management, irradiation, embolization etc. In this case report, we describe the natural history, clinical course and successful surgical management of a patient with haemophilia who presented with a massive pseudotumour. We also briefly review the relevant literature on the various therapeutic modalities that have been implemented in the management of this rare complication. Though surgeons may be averse to operate on haemophiliacs, primary surgical management as done in our case may prove to be the definitive treatment option for such patients.