1.
Chem Biol Drug Des
; 79(5): 790-7, 2012 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22284812
RESUMO
Dihydroperoxides and tetraoxanes derived from symmetrically substituted bis(arylmethyl)acetones were synthesized in modest to good yields using several methods. Three of these compounds exhibit an important in vitro antimalarial activity (1.0 µm ≤ IC(50) ≤ 5.0 µm) against blood forms of the human malaria parasite Plasmodium falciparum.