1.
Bioorg Med Chem Lett
; 22(1): 190-3, 2012 Jan 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-22119469
RESUMO
We report the discovery of a novel series of spiroindoline-based inhibitors of Sky kinase that bind in the ATP-binding site and exhibit high levels of kinome selectivity through filling the Ala571-subpocket. These inhibitors exhibit moderate oral bioavailability in the rat due to low absorption across the gut wall.