[Comparative evaluation of effects of p-tyrosol and Rhodiola rosea extract on bone marrow cells in vivo]. / Sravnitel'naia otsenka deistviia p-tirozola i ékstrakta podioly rozovoi na kletki kostnogo mozga in vivo.

The effects of p-tyrosol and Rhodiola rosea extract on the hemopoietic system were compared on a model of subacute lead intoxication. No significant differences between the activity of two preparations were revealed by the study of plasma membrane blebbing, apoptosis, and necrosis processes in bone marrow. At the same time, p-tyrosol exhibited a more pronounced effect upon lipid peroxidation and offered significant protection against lead intoxication.

[Oxidative stress and zinc chloride-induced gamete impaired morphology]. / Okislitel'nyi stress i narushenie formologii gamet, indutsiruemye khloridom tsinka.

An in vivo study investigated the toxic effect of zinc chloride on murine spermatozoids. Acute and subacute intoxication was found to increase the quantity of TBC active products and to induce the growth of degenerative forms of spermatozoids.

Doxorubicin modulates biological effects of ATP in bone marrow cells in vitro.

ATP activity in mouse bone marrow cells was studied in in vitro experiments. ATP in physiological and supraphysiological concentrations stimulated blebbing of the plasma membrane. Subacute administration of doxorubicin (inductor of oxidative stress) decreased cell sensitivity to ATP, which corresponded to changes in membrane lipid peroxidation.

NAD and glutathione modulate sensitivity of bone marrow cells to oxidative stress.

We studied in vitro cytostatic effect of doxorubicin on bone marrow cells preincubated with NAD and reduced glutathione. The presence of NAD and glutathione in the medium potentiated membrane toxicity of this antibiotic, but prevented its toxic effects on intracellular pool of pyridine nucleotides during oxidative stress.

Modification of membrane-toxic effect of Nd-YAG laser by preliminary induction of cytochrome P-450 in bone marrow cells.

The cytotoxic effects of Nd-YAG laser with a wavelength of 533 nm were studied in mouse bone marrow cells in vitro. Laser exposure caused blebbing of bone marrow cell plasma membrane. Preliminary induction of cytochrome P-450 with 3-methylcholanthrene modified the cytotoxic effect of Nd-YAG laser.

Early effects of cis-dichlorodiammine platinum (II) on tumor progression and programmed death of Ehrlich ascites carcinoma cells.

We studied the effects of cis-dichlorodiammine platinum (II) on different pathways of cell death in cultured Ehrlich ascites carcinoma in vitro and on subsequent growth of transplanted tumor in vivo. One-hour incubation with the cytostatic modulated apoptosis in cell culture. However, exposure of cell culture to a minimal effective concentration of cis-platinum(II)diammine dichloride promoted the growth of transplanted tumor.

Metabolism in perfused rat lived at different terms after short-term hyperthermia.

The metabolic state of rat liver was studied in vivo 1, 6, and 18 h after single hyperthermia (42 degrees C). It was shown that intracellular compensatory reactions involved in restoration of the energy state and realization of endogenous cytoprotective mechanisms play a role during recovery.

[Disorder of the serotoninergic regulation of bone marrow cell proliferation under the action of a xenobiotic inducer of oxidative stress]. / Narushenie serotoninergicheskoi reguliatsii proliferatsii kletok kostnogo mozga pri deistvii ksenobiotika-induktora okislitel'nogo stressa.

The work shows the results of experimental study of the characteristics of serotonin regulation of cell proliferation and programmed cell death in bone-marrow cells cultivated in diffusion chambers. It was found that the change in cell colony and cluster formation and death induced by this biogenic enzyme is disturbed by acrylamide, an inducer of oxidizing stress. Nicotinamide levels out the effect of acrylamide, which is evidence of the existence of NAD-dependent mechanisms in the serotonin-mediated regulation of hemopoiesis.

[Genotoxic effect of acrylates]. / Genotoksicheskii éffekt akrilatov.

Study of mutagenic activity of butylacrylate and methyl methacrylate on bone marrow cells of rat was carried out. Mutagenic activity of both of them was noted, but the butylacrylate was more active.