[The pharmacokinetic characteristics of drug absorption in the oral cavity]. / Farmakokineticheskie osobennosti vsasyvaniia lekarstvennykh veshchestv v polosti rta.

The review presents the literature data on the peculiarities of effects of the drugs administered in the systemic blood flow by using application to different areas of the oral mucosa.

[Pain-alleviating action of gidifen and its combinations with analgesics]. / Izuchenie boleutoliaiushchego deistviia gidifena i ego sochetanii s anal'getikami.

The analgesic effect of gidifen, a new tranquilizer belonging to the group of organophosphorus compounds, manifests itself in relatively high doses (1/3 of the LD50). The quantitative characteristics of the analgesic action depends on the method for evaluating the analgesic action of the drug. On combined use of gidifen and analgesics applied in a definite dosage range the analgesic effect is potentiated. If the tranquilizer under study is combined with non-narcotic analgesics, the above potentiation is accompanied with an increase in the toxicity and myorelaxant activity of gidifen. On combination of the latter with morphine the parameters under consideration are unchanged. According to the pattern of interaction with analgesics gidifen does not differ in principle from benzodiazepine tranquilizers. However, the drug is not superior to benzodiazepines in this respect.

[Effect of morphine and amidopyrine on the blood serum protein spectrum against a background of steroid hormone administration]. / Vliianie morfina i amidopirina na belkovyi spetr syvorotki krovi na fone vvedeniia steroidnykh gormonov.

Administration of morphine and amidopyrin in experimental hypercorticism (hydrocortisone and DOCSA excess) results in the increased content of albumins and the decreased level of globulins. On the whole, the pattern of action of the steroid hormones on the protein spectrum of blood remains unchanged even after administration of analgesic agents.

[Action of morphine and amidopyrine against a background of mineralocorticoid hormone and its antagonist]. / Deistvie morfina i amidopirina na fone mineralokortikoidnogo gormona i ego antagonista.

The effect of morphine and amidopyrine, used against the background of a mineralocorticoid hormone or its antagonist excess (multiple administration of desoxycorticosteron acetate or verospiron), is mitigated. The pain-allaying effect of analgesics and their influence on the behavioral reactions are less marked in both models than it is in intact animals and their toxocity is down.

[Study of the pharmacodynamics of morphine and aminopyrine under conditions of alloxan diabetes]. / Izmenenie farmakodinamiki morfina i aminopirina v usloviiakh alloksanovogo diabeta

The effects of morphine and amidopyrine were studied in tests on albino rats with experimental alloxan diabetes. Investigations showed the analgesic effects of morphine and the pupillary reflex following administration of this drug to subside, its toxicity remaining stationary. The anodyne action of amidopyrine and its toxicity grow in intensity.

[Effect of tranquilizers and analgesics on the permeability of the histohematic barriers for sulfacyl in inflammation]. / Vliianie trankvilizatorov i anal'getikov na pronitsaemost' gisto-gematicheskikh bar'erov dlia sul'fatsila v usloviiakh vospaleniia

The effect of neurotropics (analgetics and tranquilizers) on the permeability of histo-blood barriers in normalcy and pathology was wound to be dissimilar. In tests conducted on intact rats the studied neurotropic agents used in pharmacological doses did not affect the permeability of the histological-blood barriers of the brain and spleen with respect to the indicator--sodium sulfacyl. In rats with an inflammation focus the same drugs produced changes of the said factor, not always similar in their orientation (rise of fall).