Recent knowledge in favor of remdesivir (GS-5734) as a therapeutic option for the COVID-19 infections.

The management of SARS-CoV-2 has not yet been clearly determined and is based on potential therapies evaluated during the SARS-CoV and MERS-CoV outbreaks. An emerging potential therapeutic approach currently being evaluated in numerous clinical trials is the remdesivir agent, which acts on COVID-19 by interfering with key steps in the virus replication cycle. It is considered a therapeutic option to be evaluated against COVID-19, based on data on its in vitro and in vivo activity against MERS-CoV and SARS-CoV coronaviruses. In this work, we provide an overview of remdesivir's discovery, mechanism of action, and the current studies exploring its clinical effectiveness. Recommendations for its use against COVID-19 infection are also summarized.

Current progress on COVID-19 related to biosensing technologies: New opportunity for detection and monitoring of viruses.

The technologies used for coronavirus testing consist of a pre-existing device developed to examine different pathologies, such as bacterial infections, or cancer biomarkers. However, for the 2019 pandemic, researchers knew that their technology could be modified to detect a low viral load at an early stage. Today, countries around the world are working to control the new coronavirus disease (n-SARS-CoV-2). From this perspective, laboratories, universities, and companies around the world have embarked on a race to develop and produce much-needed test kits. This review has been developed to provide an overview of current trends and strategies in n-SARS-CoV-2 diagnostics based on traditional and new emerging assessment technologies, to continuous innovation. It focuses on recent trends in biosensors to build a fast, reliable, more sensitive, accessible, user-friendly system and easily adaptable technology n-SARS-CoV-2 detection and monitoring. On the whole, we have addressed and identified research evidence supporting the use of biosensors on the premise that screening people for n-SARS-CoV-2 is the best way to contain its spread.

Ibuprofen analysis in blood samples by palladium particles-impregnated sodium montmorillonite electrodes: Validation using high performance liquid chromatography.

The electrochemical detection of ibuprofen has been studied on Palladium-Montmorillonite (Mt) modified carbon paste electrode using differential pulse voltammetry. The optimization of the modifier preparation and the instrumental parameters was investigated. The results indicate that ibuprofen oxidation was favored in the presence of Pd-PdO particles. The quantitative determination of ibuprofen was statistically analyzed and validated using HPLC method. The detection and quantification limits, specificity and precision were found to be acceptable. Finally, the developed method was successfully applied for ibuprofen determination in human blood samples.

Square wave voltammetric determination of paracetamol at chitosan modified carbon paste electrode: Application in natural water samples, commercial tablets and human urines.

A novel analytical approach has been developed and evaluated for the quantitative analysis of paracetamol (PCT). The anodic peak currents of paracetamol on the CS-CPE were about 200 fold higher than that of the unmodified electrodes. The influence of various parameters on the CS-CPE was investigated. Under the optimized working conditions, the oxidation peak current is linear to the paracetamol concentration in the ranges of 1.0 × 10(-3)-4.0 × 10(-4)mol L(-1) and 2.0 × 10(-4)-8.0 × 10(-7)mol L(-1) with a detection limit of 5.08 × 10(-7)mol L(-1). The repeatability of the method expressed as relative standard deviation (RSD) is 1.73% (n=8). Possible interferences were tested and evaluated in 1.0 × 10(-4)mol L(-1) paracetamol in the presence of inorganic ions, dopamine, ibuprofen, ascorbic acid and uric acid. The proposed method was successfully applied to PCT determination in natural waters, tablets and urine samples.