Bimetallic nanoparticles supported on Ce-BTC for highly efficient and stable reduction of nitroarenes: Towards environmental sustainability.

The development of a catalyst with a consistent and clearly defined crystal structure is crucial for establishing an efficient catalytic performance system. This study focuses on catalyzing the reduction of nitroarenes to amino-derivatives in an aquatic environment at ambient temperature, employing metallic (Au) and bimetallic (Au-Pd or Au-Ag) nanoparticles loaded on a Ce-BTC metal-organic framework using a facile sol-immobilization approach. Diverse analytical instruments, comprising SEM, TEM, XRD, FT-IR, XPS, TGA, and N2 isotherm, have been utilized to characterize the synthesized catalysts. Among the catalysts that were fabricated, Au-Pd@Ce-BTC displayed the maximum catalytic efficacy, offering a rate constant (kapp) of 0.5841 min-1, conversion percentages reaching 99.7%, and a KAF of 116.8 min-1g-1. Moreover, it exhibited remarkable recyclability over five consecutive cycles. This catalyst offers the advantages of operating under ambient reaction conditions and exhibiting tolerance to a broad range of substrates containing various functional moieties. The mechanistic understanding of nitroarene reduction and the factors contributing to the superior activity of Au-Pd/Ce-BTC are explored through spectroscopic and porosity analyses. Spectroscopic measurements indicate that the elevated Auo and Pdo/Pd2+ ratio, increased surface area, and the synergistic collaboration of the bimetallic NPs are key factors contributing to the heightened activity of Au-Pd/Ce-BTC. These findings hold significant appeal from both an industrial and academic standpoint.

Electrospun TiO2-GO/PAN-CA nanofiber mats: A novel material for remediation of organic contaminants and nitrophenol reduction.

The outstanding properties of nanofiber composites have made them a popular choice for various structural applications. Recently, there has been a growing interest in using electrospun nanofibers as reinforcement agents, which possess exceptional properties that can enhance the performance of these composites. Herein, TiO2-graphene oxide (GO) nanocomposite incorporated into polyacrylonitrile (PAN)/cellulose acetate (CA) nanofibers were fabricated by an effortless electrospinning technique. The chemical and structural characteristics of the resulting electrospun TiO2-GO nanofibers were examined employing diverse techniques such as XRD, FTIR, XPS, TGA, mechanical properties, and FESEM. Remediation of organic contaminants and organic transformation reactions with electrospun TiO2-GO nanofibers were performed. The results indicated that the incorporation of TiO2-GO with various TiO2/GO ratios did not affect the molecular structure of PAN-CA. Still, they did significantly increase the mean fiber diameter (234-467 nm) and the mechanical properties of the nanofibers comprising UTS, elongation, Young's modulus, and toughness compared to PAN-CA. From various ratios of TiO2/GO (0.01TiO2/0.005GO and 0.005TiO2/0.01GO) in the electrospun NFs, the nanofiber containing a high content of TiO2 showed over 97% of the initial MB dyes were degraded after 120 min of visible light exposure and the same nanofibers also, achieved 96% nitrophenol conversion to aminophenol in just 10 min with activity factor kAF value of 47.7 g-1min-1. These findings illustrate the promise of TiO2-GO/PAN-CA nanofibers for use in various structural applications, particularly in the remediation of organic contaminants from water and organic transformation reactions.

Efficient Dual-Function Catalyst: Palladium-Copper Nanoparticles Immobilized on Co-Cr LDH for Seamless Aerobic Oxidation of Benzyl Alcohol and Nitrobenzene Reduction.

Layered double hydroxides (LDHs) present exciting possibilities across various industries, ranging from catalytic applications to water remediation. By immobilizing nanoparticles, LDHs' characteristics and functionality can be enhanced, allowing for synergetic interactions that further expand their potential uses. A simple chemical method was developed to produce well-dispersed Pd-Cu NPs on a Co-Cr LDH support using a combination of in situ coprecipitation/hydrothermal and sol-immobilization techniques. The Pd-Cu@Co-Cr LDH catalysts was obtained, showing its catalytic activity in promoting the aerobic oxidation of alcohols and enabling the reduction of nitro-compounds through NaBH4 mediation. The physicochemical properties of the prepared catalyst were comprehensively investigated utilizing a range of analytical techniques, comprising FTIR, XRD, XPS, TGA, nitrogen adsorption isotherm, FESEM, and HRTEM-EDX. The findings showed the significance of immobilizing the bimetallic Pd-Cu nanoparticles on the Co-Cr LDH via an exceptional performance in the aerobic oxidation of benzyl alcohol (16% conversion, 99.9% selectivity to benzaldehyde) and the reduction of nitrobenzene (98.2% conversion, rate constant of 0.0921 min-1). The improved catalytic efficacy in benzyl alcohol oxidation and nitrobenzene reduction on the Pd-Cu@Co-Cr LDH catalyst is attributed to the uniform distribution and small size of the Pd-Cu NPs as active sites on the Co-Cr LDH surface. The prepared catalyst demonstrated exceptional stability during repeated runs. This study paves the way for multiple opportunities in tailoring, producing, and precisely controlling catalysts for various organic transformation reactions.

Efficient nitrophenol reduction with Noria-GO nanocomposite decorated with Pd-Cu nanoparticles.

We report a facile approach to synthesize Pd-Cu nanoparticles immobilized on a Noria-GO nanocomposite for efficient nitrophenol reduction. The unique architecture of the Noria and the hydrophilic nature of GO contribute to the improved performance and structure of the resulting nanocomposite. The simple sol-immobilization approach employed NaBH4 as a reductant and polyvinyl alcohol as a capping agent to evenly decorate small Pd-Cu nanoparticles with a diameter of 1.4 nm on the Noria-GO surface. The prepared Pd-Cu@Noria-GO nanocomposite was utilized as a nanocatalyst in converting of nitrophenol to aminophenol using NaBH4 solution. Our Pd-Cu@Noria-GO nanocomposite exhibited superior catalytic efficacy with large conversion percentages, Kapp, and KAF values of 95%, 0.225 min-1, and 225 min-1g-1, respectively. X-ray photoemission spectroscopy confirmed the oxidation state of the prepared nanoparticles, and TEM findings demonstrated the homogenous decoration of Pd-Cu NPs on the Noria-GO surface. Additionally, the durability of the Pd-Cu@Noria-GO nanocomposite shown its potential as a robust and promising material for remediating organic contaminants. Our results indicate that Pd-Cu@Noria-GO nanocomposite can be an effective and sustainable approach for mitigating the hazards associated with nitrophenols.

Tailoring confined CdS quantum dots in polysulfone membrane for efficiently durable performance in solar-driven wastewater remediating systems.

In this work, CdS quantum dots (QDs) were successfully confined in polysulfone membrane (PSM) to develop a photoactive membrane under solar illumination that was suited in wastewater remediating system. The CdS@PSM membranes were prepared using the nonsolvent induced phase separation (NIPS) approach. Optical measurements show the confinement of CdS quantum dots (QDs) in the PS matrix within the narrowest band gap (2.41 eV) at 5 wt% loading. PS has two strong emission peaks at 411 and 432 nm due to photoelectron-hole recombination on pure PSM's surface. Adding 1 wt% CdS QDs to PSM reduced the earlier peak and blue-shifted the latter, within the appearance of three emission peaks attributed to the near band-edge emission of confined CdS QDs. Overloading CdS reduced all emission peaks. Moreover, fluorimetric monitoring of •OH radicals indicates that PSM produces the least amount of photogenerated •OH radicals while CdS@PSM(5 wt%) achieved the highest productivity. Examining the developed membranes in detoxifying methylene blue (MB) from aqueous solution of natural pH 8.1 showed weak adsorption in dark over 90 min of contact while switching to solar illumination significantly photodegrade MB where the degradation efficiency starts from 49% for pure PSM to 79% for CdS@PSM(5 wt%). Influence of pH was found crucial on photodegradation efficacy. Acidic pH 3 showed the weakest photodegradation efficacy, while the alkaline pH 12 was 18.88 times more effective. The used CdS@PSM (5 wt%) was successfully photo-renovated by soaking in 10 mL of NaOH solution under Solar illumination for 15 min to be used in 4 consecutive photodegradation cycles with insignificant decrease in efficacy. These findings are promising and could lead to a high-efficiency, sustainable photocatalytic suite.

Valuation of rice straw residues: Production of silylated methylcellulose containing propylamine and propylethylenediamine for use as anticorrosion and antibacterial.

Green technology is a scientific movement seeking to eliminate industrial chemicals and replace them with natural products by valorizing natural resources or biological waste. In this work, we present the extraction of cellulose from rice straw and chemically modified water-dispersible cellulose (methylcellulose) by performing a methylation process. The methylcellulose is chemically bonded to N-[3-(trimethoxysilyl)propyl]ethylenediamine, and (3-aminopropyl)triethoxysilane compounds to produce a cellulose-organosilane hybrid. The prepared compounds were studied with appropriate techniques such as 1H NMR, XRD, FTIR, TGA, Raman spectroscopy, FE-SEM, and AFM. The prepared materials were used as corrosion inhibitors of steel in 1 N H2SO4 for studies of potentiodynamic polarization measurements and electrochemical impedance spectroscopy. The materials were also studied as antibacterial agents. The results indicate the successful use of a modified extracted cellulose hybrid in the corrosion field and as an antibacterial agent. Quantum chemical assessments based on density functional theory (DFT) of the trimethoxysilyl propylamine and dimethoxymethylsilyl propylethylenediamine grafted methylcellulose were calculated. The results obtained showed the agreement of the theoretical data with the experimental data.

A novel ß-cyclodextrin/alginate-combined-nickel oxide nanosorbent for adsorptive remediation of 51Cr and 56Mn radionuclides.

A Promising nanocomposite from ß-Cyclodextrin/Alginate (ß-CD/Alg) composite impregnated with nickel oxide nanoparticles (NiO) has been synthesized and characterized using diverse techniques like FT-IR, XRD, TGA, and SEM. The new nanocomposite has been investigated for the efficient remediation of 51Cr and 56Mn radionuclides from simulated contaminated radioactive water. All the controlling experimental parameters such as solution pH, contact time, initial radionuclides concentration and adsorbent mass have been investigated and optimized. The distribution coefficient values Kd (mL/g) for 51Cr and/or 56Mn radionuclides have been calculated for all factors it was found that the optimum pH values were at 5 and 6 with Kd 5300, and 4500, for 51Cr and/or 56Mn, respectively and the equilibrium was at 90 and 100 (min) with Kd values 5600 and 4800 for 51Cr and/or 56Mn, respectively.

Discriminatory of some morphometry and biological aspects of the Cycad blue butterfly, Chilades pandava reared on Cycas and Zamia ornamental palms.

The serious blue butterfly, Chilades pandava -Horsfield, 1829- (Lepidoptera: Lycaenidae) is consider one of the main destructive insect pests for ornamental palms Cycas and Zamia. Biological and morphological measurements were carried out of C. pandava stages reared on Cycas revoluta (Cycadaceae) and Zamia encephalartoides (Zamiaceae). In description details, non-significant variations were recorded between the two gender of cycad blue butterfly in the obtained data, but the male adult was more densely blue or violet than female adult. By the aid of SEM, C. pandava all stages were distinct by long and thick hairs covered all the body. The morphometric characters namely, length, width and venation of wings, body length, forewing, hindwing could be as a guide for taxonomic discrimination. The data showed that the life cycle duration of C. pandava was ranged between 20.64 to 21.7 days. The developmental periods of different C. pandava stages are slightly higher on zamia than cycas palms. This investigation detected that a high survival rate was found on Cycas palms (86%) than the survived rate recording on Zamia palms (82%). In the present study, the described morphometric characters could be used as a guide for taxonomic discrimination of this pest. Consequently, this study added a valuable knowledge about C. pandava to have sound decisions for proposal of its management and conservation in Egypt.

Alginate/κ-carrageenan oral microcapsules loaded with Agaricus bisporus polysaccharides MH751906 for natural killer cells mediated colon cancer immunotherapy.

The current study explores the effect of the extracted novel Mushroom polysaccharides and its formulation onto Alginate (Alg.)/kappa carrageenan microcapsules to exert immunotherapeutic effect upon activating gut resident natural killer cells (NK) against colon cancer. The extracted polysaccharides of Agaricus bisporus MH751906 was microcapsulated in Alg/κ-carrageenan microcapsules as an oral delivery system for colon cancer. The microcapsule is characterized by SEM, FTIR, Raman and TGA; and showed a superior acidic stability, controlled release, and thermal stability at high temperature with higher hydrogel swelling rate in colon-mimicking pH. Upon activation of human NK cells with microcapsules (ANK cells), a significant increase in CD16+CD56+ NK cell populations were recorded. These activated NK cells showed 74.09% cytotoxic effects against human colon cancer Caco-2 cells where majority of cancer cell populations arrested at G0/G1 phase leading to apoptosis. The apoptotic molecular mechanism induced by ANK cells on Caco-2 treated cells is through down regulations of both BCL2 and TGF surviving genes and up regulation in IkappaB-α gene expression. Therefore, this novel polysaccharides-alginate/κ-carrageenan microcapsules can be used as an oral targeted delivery system for colon cancer immunotherapy.

Biotechnological Applications of Polymeric Nanofiber Platforms Loaded with Diverse Bioactive Materials.

This review article highlights the critical research and formative works relating to nanofiber composites loaded with bioactive materials for diverse applications, and discusses the recent research on the use of electrospun nanofiber incorporating bioactive compounds such as essential oils, herbal bioactive components, plant extracts, and metallic nanoparticles. Inevitably, with the common advantages of bioactive components and polymer nanofibers, electrospun nanofibers containing bioactive components have attracted intense interests for their applications in biomedicine and cancer treatment. Many studies have only concentrated on the production and performance of electrospun nanofiber loaded with bioactive components; in this regard, the features of different types of electrospun nanofiber incorporating a wide variety of bioactive compounds and their developing trends are summarized and assessed in the present article, as is the feasible use of nanofiber technology to produce products on an industrial scale in different applications.

Dietary supplementation of silver-silica nanoparticles promotes histological, immunological, ultrastructural, and performance parameters of broiler chickens.

Silver nanoparticles (AgNPs) have been used as a promising alternative to antibiotics in poultry feed. In this study, silver-doped silica nanoparticles (SiO2@AgNPs) were prepared in powder form, using starch, via the chemical reduction method and sol-gel technique followed by full characterization. SiO2@AgNPs were added to the poultry diet at three doses (2, 4, and 8 mg/kg diet). The safety of the oral dietary supplementation was estimated through the evaluation of the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination of all body organs was also performed. Results of this study showed that SiO2@AgNPs have no negative effects on the growth performance and hematological, biochemical, and oxidative parameters of birds. Moreover, the immunohistochemical examination revealed the minimum inflammatory reactions and lymphoid depletion under a dose level of 8 mg/kg. In conclusion, SiO2@AgNPs could be considered as a promising and safe nano-growth promoter in broilers when added to poultry diet under a dose level of 4 mg/kg diet.

Wound dressing of chitosan-based-crosslinked gelatin/ polyvinyl pyrrolidone embedded silver nanoparticles, for targeting multidrug resistance microbes.

Wound dressing composed of chitosan, based crosslinked gelatin/ polyvinyl pyrrolidone, embedded silver nanoparticles were fabricated using solution casting method. The membrane was characterized by FTIR, SEM and TGA. Glutaraldehyde (0.5 %) was used for the crosslinking of membrane components and associated with 7-folds boosted mechanical performance, 28 % more hydrolytic stability, 3-folds thickness reduction and morphological roughness. Silver nanoparticles were characterized by UV-vis, XRD and TEM for an average size of 9.9 nm. The membrane with higher concentration of silver nanoparticles showed maximum antibacterial activity against human pathogenic bacteria; and the measured inhibition zones ranged from 1.5 to 3 cm. The activity of the particles ranged from severe to complete reduction in Penicillin, Erythromycin and Macrolide family's resistance genes expression such as ß-Lactamase, mecA and erm. This developed membrane can serve as promising and cost-effective system against severe diabetic and burn wound infections.

Wound healing of nanofiber comprising Polygalacturonic/Hyaluronic acid embedded silver nanoparticles: In-vitro and in-vivo studies.

The current study is pertaining to develop a novel wound dressing, comprising natural biologically absorbable materials for wound healing In-vivo. Wound dressing is composed of Polygalacturonic acid, Hyaluronic acid embedded silver nanoparticles, which is further fabricated to form nanofibrous mat, using electrospinning. Silver nanoparticles was prepared using PGA. AgNPs in this formula will serve as an antioxidant and anti-inflammatory that protect cells from destructive effect of elevated ROS and accelerate wound healing. The physical performance and water contact angle for nanofiber was evaluated. The produced nanofiber was characterized by Fourier-transform infrared (FTIR), scanning electron microscopy and thermal analysis. Also, the embedded AgNPs was also characterized by UV-vis spectroscopy and TEM. The nanofiber mates embedded AgNPs was applied to the wounded site of albino rats in-vivo. Histopathological assessment for the wound was fully performed. Also, the antimicrobial activity for the fabricated wound dressing was evaluated against gram+ve and gram -ve bacteria.

Alginate based tamoxifen/metal dual core-folate decorated shell: Nanocomposite targeted therapy for breast cancer via ROS-driven NF-κB pathway modulation.

Breast cancer endocrine resistance prevents unleashing full capabilities of Tamoxifen (TMX), besides TMX off-target side effects on healthy tissue. In this study, we engineered TMX nanocomposite via co-loading it on alginate-based silver nanoparticles and embedding within folic acid-polyethylene glycol surface conjugate. The coating process was done by w/o/w double emulsion method. To confirm the silver nanoparticles formation, UV spectroscopy, XRD and TEM analysis were carried out. TEM results confirmed the core-shell structure of folate targeted nanocomposite with approximate average diameter of 66 nm, the nanocomposite structures were characterized by FTIR, TGA and SEM. By comparing with the non-targeted formula, folate decorated formula had 12-folds lowered IC50 value and 12.5-14-fold higher cancer cells toxic selectivity index. Also, after 4 h treatment, both fluorescence microscopic and flow cytometric analysis indicated higher intracellular accumulation of folic acid conjugated formula on MCF-7 cancer cells than the non-targeted one with 3.44-folds. The breast cancer cytotoxic effects of this metal-endocrine nanocomposite formula could be explained by the induction of reactive oxygen species (ROS), down regulation of survival oncogenic genes (BCL-2 and Survivin) and the accumulation of MCF-7 cells in G2/M phase. All these data confirm the efficiency and efficacy of the formulated nanocomposite as future treatment for breast cancer.

Rhizofiltration system consists of chitosan and natural Arundo donax L. for removal of basic red dye.

Arundo donax L. (A. donax) plant, which are naturally grown, is capable of removing heavy metals, toxins and dyes from the environment. In addition the cell structure A. donax enable the whole to make phytoremdation for the most of environmental pollutions. For that reasons, the A. donax cells were obtained and dispersed in polymer compost to form what is called bio-chemical/dye removing system. In details; Polymeric beads were fabricated from natural low cost materials of chitosan (Cs), A. donax (cells), gelatin (GP) and poly vinyl pyrrolidone (PVP) to be applied as a powerful sorbent for CI Basic Red 14 dye. The morphological structure of the fabricated beads was investigated by Scanning Electron Microscope (SEM) and the results revealed that most immobilized A. donax cells into beads and micro-clusters are formed inside the beads. The effect of experimental variables such as sorbent dose, initial dye concentration, pH, and contact time were investigated. Freundlich and Langmuir isotherm models were applied to describe sorbent-dye sorption system. Equilibrium isotherms of CI Basic Red 14 dye on the fabricated beads were obtained, where the first-order rate model is more appropriate.

Electrospun Polyvinyl Alcohol/ Pluronic F127 Blended Nanofibers Containing Titanium Dioxide for Antibacterial Wound Dressing.

In this study, an antibacterial electrospun nanofibers for wound dressing application was successfully prepared from polyvinyl alcohol (PVA), Pluronic F127 (Plur), polyethyleneimine (PEI) blend solution with titanium dioxide nanoparticles (TiO2 NPs). PVA-Plur-PEI nanofibers containing various ratios of TiO2 NPs were obtained. The formation and presence of TiO2 in the PVA-Plu-PEI/ TiO2 composite was confirmed by X-ray diffraction (XRD). Transmission electron microscopy (TEM), Fourier transform infrared (FTIR), thermal gravimetric analysis (TGA), mechanical measurement, and antibacterial activity were undertaken in order to characterize the PVA-Plur-PEI/TiO2 nanofiber morphology and properties. The PVA-Plu-PEI nanofibers had a mean diameter of 220 nm, and PVA-Plur-PEI/TiO2 nanofibers had 255 nm. Moreover, the antimicrobial properties of the composite were studied by zone inhibition against Gram-negative bacteria, and the result indicates high antibacterial activity. Results of this antibacterial testing suggest that PVA-Plur-PEI/TiO2 nanofiber may be effective in topical antibacterial treatment in wound care; thus, they are very promising in the application of wound dressings.

Controlled drug release from cross-linked κ-carrageenan/hyaluronic acid membranes.

In this work, hydrogel membrane composed of; kappa carrageenan (κC) and hyaluronic acid (HA) crosslinked with epichlorohydrine is produced. The optimum condition has been established based on their water absorption properties. Tensile strength (TS) and elongation (E%) for the formed films are evaluated. The obtained films were characterized by FTIR, scanning electron microscopy (SEM) and thermal analysis. All membranes were loaded with l-carnosine as a drug model. The swelling properties and kinetics of the release of the model drug from the crosslinked hydrogel membrane were monitored in buffer medium at 37°C. The equilibrium swelling of films showed fair dependency on the high presence of HA in the hydrogel. Moreover, the cumulative release profile increased significantly and ranged from 28% to 93%, as HA increases. SEM explored that, the porosity increased by increasing HA content; consequently, drug release into the pores and channels of the membranes is facilitated. In addition, water uptake % increased as well. A slight change in TS occurred by increasing the HA% to κC, while the highest value of strain for κC membrane was 498.38% by using 3% HA. The thermal stability of the κC/HA was higher than that of HA.

k-Carrageenan/poly vinyl pyrollidone/polyethylene glycol/silver nanoparticles film for biomedical application.

Biopolymer composite film containing k-carrageenan (KC), polyvinyl pyrrolidone (PVP), and polyethylene glycol (PEG) was formulated by dissolving KC and PVP in water containing PEG. Silver nanoparticles (AgNPs), was produced by Honeybee and added to solution. Finally, all solutions were poured onto dishes and dried overnight at 40°C to form the final films. Tensile strength (TS) and elongation (E %) is evaluated. The water contact angle is inspected. Thermal properties (TGA) and swelling behavior for water were considered. Fungal activity is also examined. Morphology of all films was also explored using scanning electron microscope. AgNPs induced significant hydrophilicity to KC-PVP-PEG film with contact angle of 41.6 and 34.7 for KC-PVP-PEG-AgNPs. Films with AgNPs exhibited higher thermal stability and strength properties than other films without. Films with AgNPs explore lower swelling behavior than other films without. Both SEM and EDX proved the deposition of AgNPs on the surface of films. Films with AgNPs showed higher activity against pathogenic fungi compared with the chemical fungicide; fluconazole.

Microencapsulation of lectin anti-cancer agent and controlled release by alginate beads, biosafety approach.

Hepatocellular carcinoma (HCC) is considered as one of the most aggressive cancer worldwide. In Egypt, the prevalence of HCC is increasing during last years. Recently, drug-loaded microparticles were used to improve the efficiency of various medical treatments. This study is designed to evaluate the anticancer potentialities of lectins against HCC while hinting to its safety usage. The aim is also extended to encapsulate lectins in alginate microbeads for oral drug delivery purposes. The extracted lectins showed anti-proliferative effect against HCC with a percentage of 60.76% by using its nontoxic dose with an up-regulation of P53 gene expression. Concerning the handling of lectin alginate microbeads for oral drug delivery, the prepared lectin alginate beads were ∼100µm in diameter. The efficiency of the microcapsules was checked by scanning electron microscopy, the SEM showed the change on the alginate beads surface revealing the successful lectin encapsulation. The release of lectins from the microbeads depended on a variety of factors as the microbeads forming carriers and the amount-encapsulated lectins. The Pisum sativum extracted lectins may be considered as a promising agent in controlling HCC and this solid dosage form could be suitable for oral administration complemented with/or without the standard HCC drugs.

Synthesis, characterization, and antimicrobial activity of poly(acrylonitrile-co-methyl methacrylate) with silver nanoparticles.

Nanotechnology is expected to open some new aspects to fight and prevent diseases using atomic-scale tailoring of materials. The main aim of this study is to biosynthesize silver nanoparticles (AgNPs) using Trichoderma viride (HQ438699); the metabolite of this fungus will help either in reduction of the silver nitrate-adding active materials which will be loaded on the surface of the produced AgNPs. Poly(acrylonitrile-co-methyl methacrylate) copolymer (poly (AN-co-MMA)) was grafted with the prepared AgNPs. The poly(AN-co-MMA)/AgNPs were examined against ten different pathogenic bacterial strains, and the result was compared with another four different generic antibiotics. The produced poly(AN-co-MMA)/AgNPs showed high antibacterial activity compared with the four standard antibiotics. Moreover, the grafting of these AgNPs into the copolymer has potential application in the biomedical field.