RESUMO
Six new cadinene sesquiterpenoids, xenitorins A-F (1-6), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia puerto-galerae. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Assuntos
Antozoários/química , Antineoplásicos/isolamento & purificação , Sesquiterpenos/isolamento & purificação , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Neoplasias do Colo , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Leucemia P388 , Neoplasias Pulmonares , Cloreto de Metileno , Camundongos , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Sesquiterpenos/química , Sesquiterpenos/farmacologia , Espectrofotometria Infravermelho , Espectrofotometria Ultravioleta , Taiwan , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
Seven new cytotoxic xenicane-type diterpenoids, 9-deoxyxeniloide-E (1), 9-deoxy-7,8-epoxyxeniloide-E (2), xeniolide-G (3), 9-deoxyxenialactol-C (4), xenibecin (5), xeniolide-H (6), and xenitacin (7), were isolated from the methylene chloride solubles of the Formosan soft coral Xenia umbellata. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Assuntos
Antozoários/química , Antineoplásicos/isolamento & purificação , Diterpenos/isolamento & purificação , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Cromatografia em Camada Fina , Neoplasias do Colo , Diterpenos/química , Diterpenos/farmacologia , Ensaios de Seleção de Medicamentos Antitumorais , Leucemia P388 , Neoplasias Pulmonares , Camundongos , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Estereoisomerismo , Taiwan , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
Three new cytotoxic prostanoids, claviridenone E-G (1-3), and three new cytotoxic steroids, stoloniferone E-G (4-6), were isolated from the methylene chloride solubles of the Formosan soft coral Clavulariaviridis. A cytotoxic cembranoid, claviolide (7), was isolated from the methylene chloride solubles of the Formosan soft coral Clavularia violacea. The structures were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
Assuntos
Antozoários/química , Antineoplásicos/isolamento & purificação , Prostaglandinas/isolamento & purificação , Esteroides/isolamento & purificação , Animais , Antineoplásicos/química , Antineoplásicos/farmacologia , Neoplasias do Colo , Ensaios de Seleção de Medicamentos Antitumorais , Humanos , Leucemia P388 , Neoplasias Pulmonares , Cloreto de Metileno , Camundongos , Conformação Molecular , Estrutura Molecular , Ressonância Magnética Nuclear Biomolecular , Prostaglandinas/química , Prostaglandinas/farmacologia , Esteroides/química , Esteroides/farmacologia , Taiwan , Células Tumorais Cultivadas/efeitos dos fármacosRESUMO
Four new cytotoxic diterpenes, cespitularins A-D (1-4), having the verticillane skeleton, a new cytotoxic norditerpene, cesputularin E (5), that possesses a novel norverticillane skeleton, and three new diterpenes, cespitularins F-H (6-8), possessing a novel carbon skeleton named cespitularane, were isolated from the methylene chloride solubles of the Formosan soft coral Cespitularia hypotentaculata. The structures of cespitularins A-H (1-8) were elucidated by 1D and 2D NMR spectral analysis, and their cytotoxicity against selected cancer cells was measured in vitro.
