A decade in focus: mixed germ cell tumors with choriocarcinoma components.

Introduction: This 10-year registry review aimed to investigate the clinical behaviour and outcomes of mixed germ cell tumours with choriocarcinoma components, a rare and aggressive subtype of testicular cancer, in Saudi Arabia. The study explores the demographic characteristics of affected patients, tumour profiles, and the mortality rate associated with this malignancy. Methods: Utilizing data from the Saudi Cancer Registry, the authors identified 33 cases of mixed germ cell tumours with choriocarcinoma components among 1001 testicular cancer cases recorded between 2008 and 2017. Demographic information, including age, marital status, region of residency, year of diagnosis, and 10-year survival status, were collected. Tumour factors, such as the basis of diagnosis, origin site, behaviour, grade, extension, and laterality, were also analyzed. Results: The majority of cases (78.8%) occurred in the young age group (18-45 years), and most tumours (97%) originated in normally descended testes. Grade IV (undifferentiated anaplastic) tumours and distant metastasis were present in 45.5% of patients. All cases exhibited malignant tumour behaviour. The overall mortality rate was 15%, with a mean time from diagnosis to death of 7.72 months (range: 0.5-21.5 months). Conclusion: Mixed germ cell tumours with choriocarcinoma components are rare and tend to affect younger populations. These tumours demonstrate aggressive clinical behaviour, with a significant proportion presenting with high-grade lesions and metastasis at diagnosis. The observed mortality rate underscores the poor prognosis associated with this malignancy. Our study provides essential insights into the clinical characteristics of this rare tumour subtype in the Saudi Arabian population, emphasizing the need for further research to identify prognostic factors and optimize management strategies for affected patients.

Persistent Median Artery, Bifid Median Nerve, and Reversed Palmaris Longus Encountered During Cadaveric Dissection: The First Reported Case.

The median artery is a transient embryological structure that normally disappears with the development of the radial and ulnar arteries. In rare instances, though, it persists as the persistent median artery (PMA). The superficial and deep palmar arches are formed through the anastomoses of the radial and ulnar arteries, giving hand and digits their main blood supply. This complex network of vessels and their anastomoses are prone to anatomical variations based on how the anastomosis occurs and which arteries contribute to this anastomosis. While it normally forms through the anastomosis of the radial and ulnar arteries, the superficial palmar arch (SPA) may also form differently, as in our case here, where the median artery persisted and branched off the radial artery, anastomosing with the ulnar artery to give rise to the SPA. This may also interfere with the normal compartmental architecture within the hand, possibly contributing to various clinical pathologies like carpal tunnel syndrome (CTS). Notably, in addition to the persistent median artery, our findings revealed a reversed palmaris longus and a bifid median nerve. These two additional variations can potentially exacerbate the risk of CTS. Alone, the coexistence of the PMA and the reversed palmaris longus is deemed a rare anomaly, only reported once in the literature. The addition of a third variation to the existing ones, like the bifid median nerve, is first reported by us and calls for more investigation for a possible genetic mutation. In this case, we report a persistent median artery, reversed palmaris longus muscle, and bifid median nerve in the forearm of a male cadaver found during a routine anatomy teaching session.

Reversed Palmaris Longus: A Rare Anatomical Phenomenon Discovered.

The palmaris longus (PL) muscle is considered by many to be a vestigial muscle due to it having little to no functional significance on the upper limb. This, however, made it highly valuable in surgical procedures, especially as a graft in plastic and reconstructive cases. Variations in the muscle's morphology were discussed in the literature, but some are more rare than others. Those variations may have clinical implications on different pathologies such as Guyon's syndrome or Carpal tunnel syndrome based on the nerves and vessels surrounding it, and thus demand a proper understanding of the variation's anatomy. Here, we report a case of one of the rarer variations, a unilaterally reversed palmaris longus muscle in the left forearm of a 55-year-old male cadaver, discovered in a routine teaching session. Throughout the case, we will discuss the normal anatomy, the variation, and the clinical implications this variation may have.

A Rare Case Report of a Vertebral Artery Variant Arising From the Aorta With Its Clinical Significance: An Uncommon Anatomy Unveiled.

The vertebrobasilar (VB) system, comprising two vertebral arteries and one basilar artery, is responsible for providing vital vascular supply to the central nervous system structures. Disruption in this network can lead to fatal neurologic outcomes, and variations in the origin of vessels may contribute to unexplained symptoms of clinical relevance. Therefore, an extensive understanding of the VB system's anatomy and its variations is crucial for diagnosing neurological disorders. Here, we report a case of a vertebral artery variant arising from the aortic arch proximal to the left subclavian artery in the cadaver of a 50-year-old male, discovered incidentally during a teaching dissection session. We also discuss the clinical pathophysiology and the relevance of the neurological symptoms in relation to the anomaly.