[Provision of complex cardioprotection with the help of carvedilol in 1-2 degree arterial hypertension combined with metabolic syndrome].

In an open prospective 16-week study we carried out assessment of clinical efficacy, vaso- and cardioprotective properties of nonselective alpha and beta-adrenoblocker carvedilol used as monotherapy and in combination with nifedipine or as combination of these drugs with metformin and simvastatin. We have shown that the use of carvedilol both as monotherapy and in combination with nifedipine normalizes arterial pressure irrespective of the number of risk factors. We also revealed pronounced cardio- and vasoprotective action without negative effect on carbohydrate and lipid metabolism.

[Clinical-functional of somatic condition and delivery in women with mitral valve prolapse]. / Kliniko-funktsional'nye osobennosti somaticheskogo sostoianiia i techeniia rodov u zhenshchin s prolapsom mitral'nogo klapana.

Pregnancy running with concomitant somatic disease, mitral prolapse (MP), in particular, remains a serious clinical problem because of MP high incidence rate and severity of complications. The author studied somatic condition, perinatal and postnatal periods in women in labor (WLs) with MP in comparison with healthy WL. A comprehensive clinical examination of 130 pregnant women, WLs and puerperae has revealed some regularities. Women with MP are more frequently affected with extragenital infectious and non-infectious diseases, have disorders of intracardiac hemodynamics. Because of frequent occurrence of anomalous labour and postnatal period, pregnant women with MP should be referred to a group of obstetric and perinatal pathology risk. The results of current research urge the necessity of a comprehensive examination of pregnant women for MP. They should be placed under early special observation, adequately treated or get advice on whether the pregnancy should be continued.

[Microbial cenoses of the nasopharynx]. / Mikrobnye tsenozy nosoglotki.

The review is devoted to nasopharyngeal microflora, its significance for macroorganisms, and to relations between main representatives of nasopharyngeal microbial associations.

[The rapid differential diagnosis of bacterial and viral meningitis by using the lysozyme test]. / Differentsial'naia ékspress-diagnotika bakterial'nykh i virusnykh meningitov s pomoshch'iu lizotsimnogo testa.

The authors have modified the technique of the lysozyme test by adding polimixin M sulfate into the gel bacterial medium. Rapid diagnosis with the use of this test is based on different time of the appearance of the lysis areas: in bacterial meningitides the CSF lysozyme activity is detectable within 15-120 min, whereas in viral meningitides it manifests 40-50 min later or does not manifest at all. The results were found to depend on the time of the CSF collection: the earlier the CSF samples were obtained, the higher was the share of positive results.

[The evaluation of the reactogenicity and immunological activity of an inactivated 3-component influenza vaccine with an elevated hemagglutinin concentration in the inoculation dosage]. / Otsenka reaktogennosti i immunologicheskoi aktivnosti inaktivirovannoi trekhkomponentnoi grippoznoi vaktsiny s povyshennoi kontsentratsiei gemaggliutinina v privivochnoi doze.

In this work the reactogenic properties and antigenic potency of inactivated trivalent influenza vaccine, obtained by elution and centrifugation and containing up to 9-11 micrograms of hemagglutinin for influenza viruses A(H1N1) and A(H3N2) and up to 14 micrograms for influenza virus B, were studied. The reactogenicity of the preparation was found to correspond to the regulations. The immunogenic potency characteristics of individual batches of this trivaccine were higher than the immunogenicity of divaccines, but did not meet the requirements of technical specifications.