[Cryoamplipulse therapy in treating patients with chronic constipation]. / Krioamplipul'sterapiia v lechenii bol'nykh khronicheskimi zaporami.

120 patients with chronic constipation (CC) were examined using assessment of the immune status, rectoromanoscopy, esophagogastroduodenoscopy, myography, stool examination for volatile fatty acids and dysbacteriosis. The patients were divided into three groups. Group 1 (n = 58) received cryoamplipulsetherapy, group 2 (n = 29)--creotherapy, group 3 (n = 33)--amplipulsetherapy. Changes in clinical and functional indices show that the response in group 1, 2 and 3 was 88, 75 and 68%, respectively.

[The management procedure for patients with cholelithiasis and the results of rehabilitative treatment after cholecystectomy based on polyclinic observations]. / Taktika vedeniia bol'nykh s zhelchnokamennoi bolezn'iu i rezul'taty vosstanovitel'nogo lecheniia posle kholetsistéktomii po nabliudeniiam v poliklinike.

Based on an analysis of the dynamic ultrasonic, biochemical and hormonal data on 550 patients operated on for cholelithiasis and comparison of preoperative and pathomorphological diagnoses, indications for surgical treatment of cholelithiasis patients in the stage of so-called "lithocarriership" were developed and a group at risk for cancer was identified as well. A comprehensive analysis of the clinical and instrumental data on 185 patients operated on for cholelithiasis, made in the long-term periods (from 1 to 3 years) after cholecystectomy indicates the efficacy of differentiated rehabilitation treatment, including elderly subjects and the necessity of early surgical treatment of cholelithiasis before there may develop irreversible alterations in the choledochus, liver and pancreas and in the gallbladder itself. Comparison of the dynamic ultrasonic data, liver and pancreas functions and factors such as sex, age, obesity and physical exercise makes it possible to predict the course of cholelithiasis to a certain degree of probability at the asymptomatic stage and to specify the policy of managing such patients under ambulatory conditions.

[Assessment of criteria for forming follow-up groups of patients at high risk for ulcerogenesis in ambulatory care]. / Otsenka kriteriev formirovaniia grupp nabliudeniia sredi lits s faktorami vysokogo riska ul'tserogeneza v usloviiakh polikliniki.

A method of clinico-laboratory examinations to reveal persons at high risk for the development of duodenal ulcer, suitable for wide use during prophylactic medical screenings was devised. The rise of the levels of serum pepsinogen-I, pepsin and hexosamines in the urine, being of prognostic importance as applicable to ulcerogenesis, was the most significant indicator in screening risk group patients. During 3 to 5 years of the screened group follow-up and carrying out health measures, peptic ulcer was ascertained in 8.4% of the patients with chronic gastroduodenitis. Of these, 66.6% had initially suffered from pylorobulbitis. It is shown that there is a real opportunity of preventing ulcer formation in patients with chronic primary gastroduodenitis under outpatient conditions.

[Evaluation of the therapeutic effect of hyperbaric oxygenation and anginin in peptic ulcer]. / Otsenka terapevticheskogo éffekta giperbaricheskoi oksigenatsii i anginina pri iazvennoi bolezni zheludka i dvenadtsatiperstnoi kishki.

Hyperbaric oxygenation (HBO) and pyridinolcarbamat were mainly applied in the treatment of elderly patients with peptic ulcer attended by coronary heart disease and atherosclerosis. To evaluate the condition of intracellular regulators after the treatment, a study was made of the time-course of changes in the content of cyclic nucleotides in blood plasma and gastric mucosa. The use of HBO in the treatment of peptic ulcer raised the efficacy of the multimodality therapy and accelerated the epithelization of erosive and ulcerative defects. The use of pyridinolcarbamat turned to produce a beneficial therapeutic effect and to be protective with respect to the gastric mucosa. Thus it was found desirable to apply the drug to the treatment of ulcers mainly occurring in the stomach. The changes in the content of cyclic nucleotides in blood plasma and gastric mucosa may play an important role in the realization of positive metabolic changes in gastric mucosa, induced by pyridinolcarbamat and HBO in peptic ulcer patients.

[Differentiated diet therapy in chronic intestinal diseases with predominance of the dyskinetic constipations syndrome]. / Differentsirovannaia dietoterapiia khronicheskikh zabolevanii kishechnika s proebladaniem sindoroma diskineticheskikh zaporov

On the ground of clinical observations, studies on the motor-evacuatory functions of the gastro-intestinal tract and its regulation values in dynamics a differentiated dietotherapy and a special complex of exercise therapy have been devised for patients with chronic colites and enterites marked by predominance of constipation. Among basic principles of this dietotherapy were: the content of all nutrients corresponding to physiological standards with the amount of protein increased up to 135 g, creating conditions conducive to sparing of the stomach, pancreas, liver and biligenic organs through exclusion of strong stimulators of the digestive and bile secretion glands, of substrates irritating the liver, regulation of the motor-evacuatory function of the gastro-intestinal tract by a graded increase in the amount of cellular membranes, progressively rising parallel with weakening of the symptoms pointing to irritation of the gastro-intestinal tract organs. The complex set of physical exercises included: those of general tonic and improving the prelum abdominale muscles tonicity, mechanically stimulating the motor function of the stomach and the intestines, periodically changing the intra-abdominal pressure, both upwards and downward.