[Role of glucocorticoids in the regulation of postexercise glycogen replenishment, and the mechanism of their action]. / Znachenie gliukokortikoidov v reguliatsii resinteza glikogena v poslerabochem periode i mekhanizm ikh deistviia.

Repeated determination of post--exercise glycogen repletion in liver, heart, white and red skeletal muscles of intact and adrenalectomized rats with or without the administration of dexamethasone and sucrose revealed that a glycogen supercompensation effect depends on the availability of glucocorticoids. Other factors which considerably modify the effect of glucocorticoids on glycogen synthesis, are the molecular properties of the mechanism through which the hormone actualizes its biological effect. The stimulating effect of dexamethasone on glycogen synthesis in the liver and heart muscle of adrenalectomized rats is blocked by cycloheximide. This suggests that the role of glucocorticoids in the regulation of post--exercise glycogen synthesis depends upon cycloheximide--sensitive protein synthesis.

[Participation of glucocorticoids in development and provisions for work capacity]. / Uchastie gliukokortikoidov v razvitii i obespechenii rabotosposobnosti.

Physical working capacity of the adrenalectomized Wistar rats can be augmented to some extent by training. This is not accompanied by increased unspecific resistance or augmented content of liver glycogen. The trained adrenalectomized rats revealed heart hypertrophy and increased activity of Mg2+-activated actomyosine ATPase in myocardium. After the training the physical worcing capacity was lower in adrenalectomized rats than in thyroidectomized ones. The 5-day administration of hydrocortisone failed to increase swimming time in adrenalectomized rats provided a high dose of progesterone was injected simultaneously. This can be due to the competition between progesterone and glucocorticoids for the glucocorticoid cytoplasmic receptor sites. The data obtained suggest that the effect of glucocorticoids on the physical working capacity is associated with their action on the adaptive protein synthesis.

[Effect of corticosteroids on content of amino acids in liver tissue during muscular activity]. / Vliianie kortikosteroidov na soderzhanie aminokislot v tkani pecheni pri myshechnoi deiatel'nosti.

Metabolism of amino acids in the liver in connection with the adrenocortical functions of the adrenals was studied in rats as affected by 3-hour swimming. This load causes an increase in the content of corticosterone in blood, in the activity of alanine aminotranspherase as well as the decrease in the amount of free amino acids in the liver tissue. These changes are absent in adrenalectomized rats and appear again when corticosterone is administered to adrenalectomized animals before swimming.

[Adrenocortical regulation of protein metabolism during prolonged physical stress]. / Adrenokortikal'naia reguliatsiia belkovogo obmena pri dlitel'nykh fizicheskikh nagruzkakh

Experiments on Wistar male rats revealed depression of labeled amino acid incorporation into the tissue proteins as a result of swimming. When prolonged swimming was accompanied by an enhanced adrenocortical activity the block of the protein synthesis in the liver proved to disappear. Adrenalectomy excluded the activation of alanine-aminotranspherase and a drop of the free amino acids in the liver during physical exercise: corticosterone administration to adrenalectomized animals restored these shifts.