Enhancement of MXene optical properties towards medical applications via metal oxide incorporation.

MXenes have garnered research attention in the field of biomedical applications due to their unique properties, such as a large surface area, low toxicity, biocompatibility, and stability. Their optical behavior makes them versatile for a wide range of biomedical applications, from diagnostics to therapeutics. Nonetheless, MXenes have some minor limitations, including issues with restacking, susceptibility to oxidation, and a non-semiconducting nature. These limitations have prompted researchers to explore the incorporation of metal oxides into MXene structures. Metal oxides possess advantageous properties such as a high surface area, biocompatibility, intriguing redox behavior, catalytic activity, semiconducting properties, and enhanced stability. Incorporating metal oxides into MXenes can significantly improve their conductivity, surface area, and mechanical strength. In this review, we emphasize the importance of incorporating metal oxides into MXenes for light-influenced biomedical applications. We also provide insights into various preparation methods for incorporating metal oxides into MXene structures. Furthermore, we discuss how the incorporation of metal oxides enhances the optical behavior of MXenes. Finally, we offer a glimpse into the future potential of metal oxide-incorporated MXenes for diverse biomedical applications.

Rheological insights on Carboxymethyl cellulose hydrogels.

Hydrogels are copiously studied for tissue engineering, drug delivery, and bone regeneration owing to their water content, mechanical strength, and elastic behaviour. The preparation of stable and mechanically strengthened hydrogels without using toxic crosslinkers and expensive approaches is immensely challenging. In this study, we prepared Carboxymethyl cellulose based hydrogels with different polymer concentration via a less expensive physical crosslinking approach without using any toxic crosslinkers and evaluated their mechanical strength. In this hydrogel system, the carbopol concentration was fixed at 1 wt/v% and the Carboxymethyl cellulose concentration was varied between 1 and 5 wt/v%. In this hydrogel system, Carbopol serves as the crosslinker to bridge Carboxymethyl cellulose polymer through hydrogen bonds. Rheological analysis was employed in assessing the mechanical properties of the prepared hydrogel, in particular, the viscoelastic behaviour of the hydrogels. The viscoelastic nature and mechanical strength of the hydrogels increased with an increase in the Carboxymethyl cellulose polymer concentration. Further, our results suggested that gels with Carboxymethyl cellulose concentration between 3 wt/v % and 4 wt/v % with yield stresses of 58.83 Pa and 81.47 Pa, respectively, are potential candidates for use in transdermal drug delivery. The prepared hydrogels possessed high thermal stability and retained their gel network structure even at 50 °C. These findings are beneficial for biomedical applications in transdermal drug delivery and tissue engineering owing to the biocompatibility, stability, and mechanical strength of the prepared hydrogels.