RESUMO
Se establecieron las condiciones de operación para la producción de la vacuna vax-SPIRAL en la escala de 100 L. Se concluyó que debe efectuarse con un flujo de aire de 10 L/min (0,1 vvm) y sin agitación mecánica(AU)
Assuntos
Leptospirose/prevenção & controle , Vacinas/farmacologia , Tecnologia Farmacêutica , Leptospira interrogans serovar canicola , FermentaçãoRESUMO
Se establecieron las condiciones de operación para la producción de la vacuna vax-SPIRAL en la escala de 100 L. Se concluyó que debe efectuarse con un flujo de aire de 10 L/min (0,1 vvm) y sin agitación mecánica
Assuntos
Leptospira interrogans serovar canicola , Leptospirose , Tecnologia Farmacêutica , Vacinas , FermentaçãoRESUMO
It was proposed to substitute the present technology of the lavage operation for a tangential microfiltration system at the lavage stages of the culture of Leptospira interrogans canicola canicola. It was proved that this system may be applied, since no cellular affectation was observed and high pollutant elimination levels were obtained.
Assuntos
Vacinas Bacterianas , Leptospira interrogans serovar canicola/crescimento & desenvolvimento , Leptospira interrogans serovar canicola/imunologia , Leptospirose/prevenção & controle , Vacinas Bacterianas/economia , Vacinas Bacterianas/imunologia , Vacinas Bacterianas/normas , Técnicas Bacteriológicas , Cuba , Filtração , Humanos , Fatores de TempoRESUMO
The operational conditions for the production of vaccine vax-SPIRAL were established at the scale of 100 L. It was concluded that it should be carried out with an air flow of 10 L/min (0.1 vvm) and without mechanical agitation.