Assuntos
Leiomioma/diagnóstico , Neoplasias Gástricas/diagnóstico , Diagnóstico Diferencial , Feminino , Humanos , Leiomioma/diagnóstico por imagem , Leiomioma/cirurgia , Pessoa de Meia-Idade , Neoplasias Gástricas/diagnóstico por imagem , Neoplasias Gástricas/cirurgia , Tomografia Computadorizada por Raios X , UltrassonografiaRESUMO
A series of omega-amino-2-hydroxy-p-fluorobutyrophenones have been synthesized to evaluate the influence exerted by a hydroxyl group in alpha-position to the carbonyl on the persistence of their neuroleptic and collateral properties. The new compounds generally did not show any neuroleptic activity while some of them were still hypotensive; this last effect, however, did not seem to be related to their alpha-adrenolytic properties.
Assuntos
Antipsicóticos/síntese química , Animais , Antipsicóticos/toxicidade , Pressão Sanguínea/efeitos dos fármacos , Butirofenonas , Catalepsia/induzido quimicamente , Fenômenos Químicos , Química , Interações Medicamentosas , Feminino , Humanos , Dose Letal Mediana , Masculino , Camundongos , Atividade Motora/efeitos dos fármacos , Norepinefrina/toxicidade , Ratos , Comportamento Estereotipado/efeitos dos fármacosRESUMO
A series of new butyrophenones was synthesized, the aim being to reduce neuroleptic activity and enhance the hypotensive effects of this class of drugs. The compounds were screened for toxicity according to the Irwin scheme and tested in anaesthetized cats for their effects on systemic arterial pressure. The most interesting compound, i.e. 1-(4'-fluorobenzoyl)-3-pyrrolidinyl-propane, was tested also in anaesthetized rabbits, cats, and dogs and in concious dogs. Moreover its central nervous system effects were tested in rats and mice. The compound proved practically devoid of neurological effects and showed interesting hypotensive activity.