Brain damage evaluation via arterial spin labeling perfusion imaging for patients with aneurysmal subarachnoid hemorrhage.

OBJECTIVE: Subarachnoid hemorrhage (SAH) is a neurological condition with an annual incidence of 6-22 per 100,000. Despite many advances in diagnosis, the rates of mortality and morbidity in patients remain high. The most important reason for this is complications accompanied by perfusion changes. The aim of our study was to show the perfusion changes with arterial spin labelling (ASL) after SAH. MATERIALS AND METHODS: In this prospective study, 23 patients diagnosed with aneurysmal SAH were evaluated by ASL perfusion imaging between days 1-3 and 8-10. The mean signal intensities (SI) of both hemispheres from the anterior cerebral artery, middle cerebral artery, and basal ganglia were measured manually according to the region of interest. The relationship between the SI values calculated for both cerebral hemispheres, complications, and grading scales of the side with more intense (ipsilateral) and less (contralateral) bleeding were evaluated. RESULTS: There was a significant difference in the ipsilateral/contralateral SI ratio (SIIps/ConBGin) (p = 0.015) among all ASL values, including the basal ganglia between days 0-3 and 8-10. There was a significant negative correlation between ASL parameters and rating scale scores. Additionally, when the SIIps/ConBGinDay0-3 ratio cut-off value was ≤ 0.72, the sensitivity and specificity were 57.1% and 100.0%, respectively, in predicting non-fatal complications, and the sensitivity and specificity in predicting all complications, including death, were 55.6% and 100.0%, respectively. CONCLUSION: Global or regional perfusion decrease can be shown using ASL, with or without the development of vasospasm, without the need for exogenous contrast agent use.

Diagnostic performance of multiparametric magnetic resonance imaging in the differentiation of clear cell renal cell cancer.

PURPOSE: This study aimed to evaluate the diagnostic performance of multiparametric magnetic resonance imaging (mpMRI) in the differentiation of renal cell carcinoma (RCC) subtypes. METHODS: This is a retrospective diagnostic performance study, in which the diagnostic performances of mpMRI features were evaluated to differentiate clear cell RCC (ccRCC) from non-clear cell RCC (non-ccRCC). Adult patients who were evaluated using a 3-Tesla dynamic contrast-enhanced mpMRI before undergoing partial or radical nephrectomy for possible malignant renal tumors were included in the study. Signal intensity change percentages (SICP) between contrast-enhanced phases and pre-administration period for both the tumor and normal renal cortex, and tumor-to-cortex enhancement index (TCEI); tumor apparent diffusion coefficient (ADC) values; tumor-to-cortex ADC ratio; and a scale which was developed according to the tumor signal intensities on the axial fat-suppressed T2-weighted Half-Fourier Acquisition Single-shot Turbo spin Echo (HASTE) images were used in ROC analysis to estimate the presence of ccRCC in the patients. The reference test positivity was the histopathologic examination of the surgical specimens. RESULTS: Ninety-eight tumors from 91 patients were included in the study, and 59 of them were ccRCC, 29 were pRCC, and 10 were chRCC. The mpMRI features that had the three highest sensitivity rates were excretory phase SICP, T2-weighted HASTE scale score, and corticomedullary phase TCEI (93.2%, 91.5%, and 86.4%, respectively). However, those with the three highest specificity rates were nephrographic phase TCEI, excretory phase TCEI, and tumor ADC value (94.9%, 94.9%, and 89.7%, respectively). CONCLUSION: Several parameters on mpMRI showed an acceptable performance to differentiate ccRCC from non-ccRCC.