RESUMO
OBJECTIVES: Lack of a rapid biochemical test for acute stroke is a limitation in the diagnosis and management of acute stroke. The aim of this study is to evaluate the efficacy of BDNF and VILIP-1 as diagnostic markers in acute ischemic stroke and as predictors of mortality. METHODS: The study included 75 patients with acute ischemic stroke older than 18â¯years. During the same period, 28 normal controls were recruited from the hospital ED. Blood samples were collected from all patients at admission to determine the levels of VILIP-1 and BDNF. RESULTS: The mean VILIP-1 levels in the study and control groups were 0.547⯱â¯0.081 and 0.515⯱â¯0.035â¯ng/mL, respectively, and the difference was not significant (pâ¯=â¯0.071). The mean BDNF levels in the study and control groups were 3.89⯱â¯2.05â¯ng/mL and 14.9⯱â¯4.7â¯ng/mL, respectively, and the level was significantly (pâ¯<â¯0.0001) lower in the stroke patients. CONCLUSION: The BDNF level showed a significant ability to discriminate stroke and control patients but did not predict mortality. The VILIP-1 level showed insignificant ability to discriminate stroke patients and again did not predict mortality.