RESUMO
OBJETIVO Y MÉTODOS: estudio observacional, longitudinal, prospectivo en el que se evaluaron los cambios en la percepción de calidad de vida en pacientes asintomáticos con hepatitis C tratados con antivirales de acción directa. RESULTADOS: los cuestionarios SF-36 y EQ-5D-5L realizados sobre 86 pacientes tratados y 12 pacientes control demostraron mejoría de varios parámetros (función física, dolor corporal, salud general, vitalidad y función social), sobre todo cuando se compara la percepción antes del tratamiento y tras finalizar el seguimiento después de la curación. CONCLUSIÓN: estos datos apoyan la hipótesis de que el virus de la hepatitis C puede causar empeoramiento en la calidad de vida de los pacientes asintomáticos
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Assuntos
Humanos , Masculino , Feminino , Pessoa de Meia-Idade , Idoso , Hepatite C/psicologia , Qualidade de Vida/psicologia , Infecções Assintomáticas/psicologia , Hepatite C/tratamento farmacológico , Antivirais/uso terapêutico , Estudos de Casos e Controles , Fatores Socioeconômicos , Inquéritos e Questionários , Estudos Longitudinais , Estudos Prospectivos , Quimioterapia Combinada , Sofosbuvir/administração & dosagem , Ribavirina/administração & dosagemRESUMO
OBJECTIVE AND METHODS: an observational, longitudinal, prospective study was performed to assess changes in perceived quality of life in asymptomatic patients with hepatitis C under treatment with direct-acting antivirals. Questionnaires SF-36 and EQ-5D-5L were administered to 86 treated patients and 12 controls. RESULTS: there were improvements in several parameters such as physical functioning, bodily pain, general health, vitality and social functioning, particularly when the perceptions were compared before treatment and after treatment completion and following recovery. CONCLUSION: these data support the hypothesis that the hepatitis C virus may worsen quality of life in asymptomatic patients.
Assuntos
Hepatite C Crônica , Qualidade de Vida , Antivirais/uso terapêutico , Hepacivirus , Hepatite C Crônica/complicações , Hepatite C Crônica/tratamento farmacológico , Humanos , Estudos Prospectivos , Inquéritos e QuestionáriosRESUMO
Se presenta el caso de una paciente con diagnóstico previo de cirrosis biliar primaria (CBP) y hepatitis B crónica en fase de portador inactivo que, en tratamiento con ácido ursodesoxicólico, presentó elevación de las transaminasas, sin datos de reactivación de su hepatitis B crónica. Se realizó biopsia hepática en la que se observaron cambios compatibles con hepatitis autoinmune (HAI) sobreañadida. Las alteraciones analíticas respondieron al tratamiento con budesonida. Se realiza una revisión sobre la entidad clínica del síndrome de solapamiento CBP-HAI y las características especiales de esta paciente para alcanzar el diagnóstico y su tratamiento (AU)
We describe the case of a female patient with a previous diagnosis of primary biliary cirrhosis (PBC) and chronic hepatitis B in inactive phase who developed increased transaminase levels with no evidence of hepatitis B virus reactivation while receiving ursodeoxycholic acid treatment. A liver biopsy showed changes compatible with overlapping autoimmune hepatitis (AIH). Budesonide treatment achieved normalization of transaminase levels. We provide a review of PBC and AIH overlap syndrome and discuss the particular features of this case that led us to this diagnosis, as well as the treatment provided (AU)
Assuntos
Humanos , Cirrose Hepática Biliar/complicações , Hepatite B Crônica/complicações , Hepatite Autoimune/complicações , Progressão da Doença , Fatores de RiscoRESUMO
We describe the case of a female patient with a previous diagnosis of primary biliary cirrhosis (PBC) and chronic hepatitis B in inactive phase who developed increased transaminase levels with no evidence of hepatitis B virus reactivation while receiving ursodeoxycholic acid treatment. A liver biopsy showed changes compatible with overlapping autoimmune hepatitis (AIH). Budesonide treatment achieved normalization of transaminase levels. We provide a review of PBC and AIH overlap syndrome and discuss the particular features of this case that led us to this diagnosis, as well as the treatment provided.
