Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 44
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Int J Pediatr Otorhinolaryngol ; 181: 111998, 2024 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-38830271

RESUMO

OBJECTIVES: This study examined the potential of ChatGPT as an accurate and readable source of information for parents seeking guidance on adenoidectomy, tonsillectomy, and ventilation tube insertion surgeries (ATVtis). METHODS: ChatGPT was tasked with identifying the top 15 most frequently asked questions by parents on internet search engines for each of the three specific surgical procedures. We removed repeated questions from the initial set of 45. Subsequently, we asked ChatGPT to generate answers to the remaining 33 questions. Seven highly experienced otolaryngologists individually assessed the accuracy of the responses using a four-level grading scale, from completely incorrect to comprehensive. The readability of responses was determined using the Flesch Reading Ease (FRE) and Flesch-Kincaid Grade Level (FKGL) scores. The questions were categorized into four groups: Diagnosis and Preparation Process, Surgical Information, Risks and Complications, and Postoperative Process. Responses were then compared based on accuracy grade, FRE, and FKGL scores. RESULTS: Seven evaluators each assessed 33 AI-generated responses, providing a total of 231 evaluations. Among the evaluated responses, 167 (72.3 %) were classified as 'comprehensive.' Sixty-two responses (26.8 %) were categorized as 'correct but inadequate,' and two responses (0.9 %) were assessed as 'some correct, some incorrect.' None of the responses were adjudged 'completely incorrect' by any assessors. The average FRE and FGKL scores were 57.15(±10.73) and 9.95(±1.91), respectively. Upon analyzing the responses from ChatGPT, 3 (9.1 %) were at or below the sixth-grade reading level recommended by the American Medical Association (AMA). No significant differences were found between the groups regarding readability and accuracy scores (p > 0.05). CONCLUSIONS: ChatGPT can provide accurate answers to questions on various topics related to ATVtis. However, ChatGPT's answers may be too complex for some readers, as they are generally written at a high school level. This is above the sixth-grade reading level recommended for patient information by the AMA. According to our study, more than three-quarters of the AI-generated responses were at or above the 10th-grade reading level, raising concerns about the ChatGPT text's readability.


Assuntos
Adenoidectomia , Compreensão , Pais , Tonsilectomia , Humanos , Tonsilectomia/métodos , Pais/psicologia , Ventilação da Orelha Média , Feminino , Masculino , Internet , Criança , Inquéritos e Questionários , Letramento em Saúde
2.
Am J Otolaryngol ; 42(6): 103111, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34273709

RESUMO

OBJECTIVE: Endoscopic ear surgery is becoming an increasingly popular approach. Our aim in this study is to evaluate the feasibility of the two-handed endoscopic technique for stapes surgery, which has its own unique steps. METHODS: Patients who underwent two-handed endoscopic stapes surgery between September 2017 and February 2018 were included in this study. Preoperative and postoperative pure tone averages and air bone gaps, intraoperative complications were recorded. All procedures were performed under hypotensive general anesthesia by the same surgeon using 0° rigid endoscopes of 2.7-mm diameter, 14-cm length with an endoscope holder. RESULTS: Seven endoscopic two-handed stapes surgery were performed between September 2017 and February 2018. Of these, six patients were operated entirely endoscopically because one patient was found to has perilymph gusher and converted to microscopic surgery. There were no intraoperative tympanic membrane injuries, facial nerve paresis or sensorineural hearing losses. The average preoperative ABG of patients who underwent fully endoscopic surgery was 31.3 dB, and the postoperative ABG closed up to 9.6 dB. CONCLUSIONS: Adoption of the two-handed technique during endoscopic stapes surgery ensures the surgeon benefits from the advantages of endoscopy while overcoming the disadvantages of the one-handed technique.


Assuntos
Endoscopia/métodos , Microcirurgia/métodos , Otosclerose/cirurgia , Cirurgia do Estribo/métodos , Audiometria de Tons Puros , Estudos de Viabilidade , Feminino , Humanos , Masculino , Otosclerose/fisiopatologia , Fatores de Tempo
3.
Am J Otolaryngol ; 42(6): 103127, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34171695

RESUMO

PURPOSE: Studies on patients with nasolacrimal duct obstruction have suggested the presence of comorbid allergic rhinitis. This study aimed to investigate the role of allergic rhinitis in the long-term surgical failure of diode laser dacryocystorhinostomy. MATERIALS AND METHODS: A total of 153 patients undergoing diode laser dacryocystorhinostomy between 2013 and 2017 were included in the study. In the consultation and follow-up, a skin prick test, endoscopic nasal examination, and nasal symptom scoring were performed. RESULTS: A total of 137 patients participated in the follow-up. The nasolacrimal obstruction complaints were completely resolved in 112 patients (81.8%). Of these, eight (7.1%) had positive skin prick tests. The preoperative complaints continued postoperatively in 25 (18.2%) patients. Nasal endoscopy revealed synechiae in one of these patients, whereas no anatomic deformities were observed in the other 24 patients. Of the 25 patients, 21 (84%) had positive skin prick tests. Those patients had signs of allergic rhinitis on endoscopic examination and high nasal symptom scores. There were significant differences in skin prick test results and nasal symptom scores between the two groups (p < 0.05). CONCLUSION: Allergic rhinitis may affect the success of dacryocystorhinostomy in patients with nasolacrimal duct obstruction. To increase the chances of surgical success, besides choosing the appropriate surgical procedure, it may be useful to treat allergic rhinitis pre- and postoperatively.


Assuntos
Dacriocistorinostomia/métodos , Obstrução dos Ductos Lacrimais , Lasers Semicondutores/uso terapêutico , Rinite Alérgica , Adulto , Comorbidade , Dacriocistorinostomia/estatística & dados numéricos , Feminino , Seguimentos , Humanos , Obstrução dos Ductos Lacrimais/epidemiologia , Masculino , Pessoa de Meia-Idade , Rinite Alérgica/diagnóstico , Rinite Alérgica/epidemiologia , Rinite Alérgica/terapia , Testes Cutâneos/métodos , Falha de Tratamento , Resultado do Tratamento
4.
Eur Arch Otorhinolaryngol ; 278(7): 2357-2362, 2021 Jul.
Artigo em Inglês | MEDLINE | ID: mdl-33386970

RESUMO

PURPOSE: This study aimed to investigate the olfactory functions of the acromegaly patients and to discuss the possible causes of olfactory dysfunction in acromegaly patients. METHODS: A case-control study was carried out in a tertiary referral center. 52 patients with acromegaly (Acromegaly group) and 52 healthy individuals (Control group) were included in the study. All acromegaly patients included in the study were in the late postoperative period. The Connecticut Chemosensory Clinical Research Center (CCCRC) test was carried out and olfactory bulb (OB) volumes were measured in both of the groups. RESULTS: There was a significant difference between the mean CCCRC total scores of the acromegaly and control groups (p = .000). The mean of right and left OB volumes in the acromegaly group was significantly higher than the control group (p = .004) CONCLUSION: In this study, we found that acromegaly patients are likely to experience olfactory dysfunction. It is important to examine these patients' olfactory functions at the time of diagnosis and clinic follow-up. CLINICAL TRIAL NUMBER: NCT04138537.


Assuntos
Acromegalia , Transtornos do Olfato , Acromegalia/complicações , Estudos de Casos e Controles , Humanos , Imageamento por Ressonância Magnética , Transtornos do Olfato/diagnóstico , Transtornos do Olfato/etiologia , Bulbo Olfatório , Olfato
5.
Am J Otolaryngol ; 41(5): 102580, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32536423

RESUMO

OBJECTIVE: The aim of this study is to apply the modified stapedectomy technique in cases with dehiscent and prolapsed facial nerve canal, and to compare the postoperative results with those with normal facial nerve canal anatomy. MATERIAL AND METHOD: 28 patients who underwent primary stapedectomy were included. Of the patients, 17 were in the normal anatomical facial nerve group, and 11 were in the dehiscent and prolapsed facial nerve group. Facial nerve was retracted with micro elevator in dehiscent and prolapsed group. and Titanium-Teflon prosthesis was angled and used in accordance with facial nerve course at this group. RESULT: No facial paresis or paralysis was observed in any patient postoperatively. In the first year, no significant difference was found in terms of air-bone gap. CONCLUSION: It is safe to retract the facial nerve for a limited time in cases of stapedectomy in cases with dehiscent and prolapsed facial nerve canal. In these cases, modifying the stapedial prosthesis in accordance with the facial nerve course does not cause disadvantage in terms of hearing gain.


Assuntos
Doenças do Nervo Facial/cirurgia , Nervo Facial/cirurgia , Prótese Ossicular , Otosclerose/cirurgia , Complicações Pós-Operatórias/cirurgia , Prolapso , Cirurgia do Estribo/métodos , Adulto , Doenças do Nervo Facial/fisiopatologia , Tubas Uterinas/anormalidades , Feminino , Audição , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
6.
Am J Otolaryngol ; 41(4): 102506, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32451291

RESUMO

OBJECTIVE: Mesna is a thiol compound effective in the connective tissue, which is used for its chemical dissector, mucolytic, mucosal damage preventive and antioxidant effects. The aim of this study was to investigate Mesna's effects in easy dissection in type 4 tympanosclerosis cases and in the prevention of formation of new sclerotic plaques. METHODS: 11 patients were included in the study. All patients were in the Wielinga Kerr type 4 class of tympanosclerosis. All patients were administered a 100% concentration of Mesna in the middle ear during tympanosclerosis surgery. All patients underwent audiological evaluation before and 20 months after the operation. Air-conduction thresholds, bone-conduction thresholds and air-bone difference were statistically compared. RESULTS: The patients were followed-up for a mean 20.48 ± 2.37 months. The mean preoperative air-conduction threshold of the patients was 58.09 ± 9.73 dB and the mean postoperative air-conduction threshold was 34.63 ± 15.46 dB and there was a significant difference. The mean preoperative bone-conduction threshold of the patients was 16.27 ± 5.47 dB and the mean postoperative bone-conduction threshold was 14.72 ± 6.11 dB and there was a significant difference. The mean preoperative air-bone gap of the patients was 41.81 ± 10.51, and the mean postoperative air-bone gap was 19.90 ± 12.48, and the difference was statistically significant. CONCLUSION: Mesna prevented hearing loss related to type 4 tympanosclerosis and prevented the formation of new sclerotic structures in our follow-up period. We believe that this effect is due to the chemical dissector and antioxidant effects of Mesna.


Assuntos
Mesna/administração & dosagem , Miringoesclerose/cirurgia , Adolescente , Adulto , Condução Óssea , Feminino , Seguimentos , Perda Auditiva/etiologia , Perda Auditiva/prevenção & controle , Humanos , Masculino , Pessoa de Meia-Idade , Miringoesclerose/complicações , Miringoesclerose/fisiopatologia , Período Perioperatório , Fatores de Tempo , Resultado do Tratamento , Adulto Jovem
7.
Am J Otolaryngol ; 41(5): 102488, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-32305253

RESUMO

OBJECTIVE: The purpose of this video presentation is to demonstrate the effect of intraoperative dilute topical fluorescein in perilympatic fistula diagnosis and localization. MATERIALS AND METHODS: Explorative tympanotomy was performed for the diagnosis, localization and repair of the fistula in the patient who had a pre-diagnosis of perilymphatic fistula. Topical fluorescein was applied intraoperatively to localize the defect. RESULT: A clear change of color was distinguished from yellow to green leading to diagnosis of the perilymphatic fistula and also showed the origin of the fistula. CONCLUSION: Topical application of dilute fluorescein is a convenient and effective tool in the diagnosis and localization of perilymphatic fistula.


Assuntos
Fístula/diagnóstico , Fluoresceína , Doenças do Labirinto/diagnóstico por imagem , Perilinfa , Fístula/patologia , Fístula/cirurgia , Humanos , Período Intraoperatório , Doenças do Labirinto/patologia , Doenças do Labirinto/cirurgia , Masculino , Pessoa de Meia-Idade , Procedimentos Cirúrgicos Otológicos/métodos
8.
Indian J Otolaryngol Head Neck Surg ; 71(Suppl 3): 1810-1815, 2019 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-31763251

RESUMO

The radiofrequency devices that are used generate radiofrequency in the frequency range of 1.5 and 2.5 MHz. This study aims to demonstrate whether systematic oxidative status and DNA are influenced in this frequency range. In study, 27 patients who received radiofrequency treatment on inferior turbinate as they were diagnosed with inferior turbinate hypertrophy. DNA damage was assessed by alkaline comet assay in peripheral lymphocyte cells. Plasma levels of total antioxidant status (TAS), total oxidative status (TOS) were determined by using an automated measurement method and oxidative stress index (OSI) was calculated (OSI was calculated as: OSI = (TOS/TAS) × 100). There were increased in the OSI and TOS values on days 1 and 15 as compared to the samples taken before the radiofrequency administration. Significant decreases were seen in TAS values on days 1 and 15. As for the DNA damage, no significant differences were found on day 15 compared to the preoperative values even though there was a statistically insignificant increase on day 1. Administration of radiofrequency radiation on inferior turbinates results in increased oxidative stress in the acute period and a decrease in the anti-oxidative system. Although this effect causes a slight increase in the DNA damage in the early post-operative period, the damage is restored to the pre-operative levels on day 15. Therefore, we believe that a more conservative approach should be selected for radiofrequency treatment instead of using it routinely.

9.
J Craniofac Surg ; 30(8): 2445-2448, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31274820

RESUMO

OBJECTIVE: In this study, the authors aimed to compare the nasal physiology and nasal cavity volume with three-dimensional computed tomography (3D-CT) 1 year after the operation with the values before the operation to investigate the possible narrowing and loss of function in the nasal cavity after septorhinoplasty (SRP) operation. METHODS: Of 415 patients who had a primary SRP operation, 28 patients who met the criteria were included in the study. Nasal cavity volumes of patients with postoperative CTs were measured three-dimensionally after a mean 13 months, and objective rhinologic measurements (rhinomanometry, acoustic rhinometry, and peak nasal inspiratory flow [PNIF]) and subjective assessment methods (Visual Analog Scale [VAS], Nasal Obstruction Symptom Evaluation [NOSE]) were performed. RESULTS: The mean postoperative VAS and PNIF values of the patients were significantly higher than the mean preoperative values. The mean postoperative NOSE value of the patients was significantly lower than the mean preoperative values. Although the mean MCA-1 and MCA-2 levels of the patients increased postoperatively, the increase was not significant. Although the postoperative mean values of VOL-1 and VOL-2 increased compared with the preoperative values, the increase was not significant. In the CT measurements of the patients, the nasal cavity volumes were significantly higher than the preoperative values. CONCLUSION: Nasal cavity volumes in patients undergoing SRP were compared with 3D-CT for the first time in the literature, and a significant increase in nasal volume was observed in the postoperative first year. This finding suggests that the correction of intranasal problems leads to an increase in the nasal volume in SRP operations, although nasal osteotomy is performed.


Assuntos
Tomografia Computadorizada de Feixe Cônico , Cavidade Nasal/diagnóstico por imagem , Adolescente , Adulto , Humanos , Pessoa de Meia-Idade , Cavidade Nasal/fisiologia , Cavidade Nasal/cirurgia , Obstrução Nasal/cirurgia , Período Pós-Operatório , Rinomanometria , Rinometria Acústica , Rinoplastia/métodos , Escala Visual Analógica , Adulto Jovem
10.
Am J Otolaryngol ; 39(5): 585-591, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-30001978

RESUMO

PURPOSE: Despite the ever-growing popularity of endoscopic ear surgery (EES), there are still concerns regarding the potential thermal risk associated with the use of light sources and also questions raised about the thermal safety of extended stationary applications of endoscopes with holders that allow the use of both hands in the middle ear. The temperature changes witnessed during EES when using different calipers on static endoscopes fitted with camera holders during true operations were measured, and effects of varying light source intensities, as well as the cooling effect of irrigation and suction, were investigated. METHODS: This study included 12 patients with chronic otitis who were scheduled to undergo myringoplasty surgery. Two of five different endoscopes with xenon light sources (4 mm-0°, 3 mm-0°, 2.7 mm-0°, 3 mm-45° and, 2.7 mm-30°) were used on each patient. Following irrigation and aspiration, gradually increasing heat measurements were recorded at two-minute intervals using a thermocouple thermometer for the entire period the endoscope remained in the ear. Three measurements obtained within the final 6 min, all of which were the same and reached a plateau, were considered to be the peak heat value. Measurements were repeated twice in each patient at 100% and 50% light intensities. RESULTS: The highest heat was recorded by the 4 mm-0° endoscope, with heats at 100% and 50% light intensity recorded as 48.4 °C and 43.2 °C, respectively. The highest heat was measured by the 2.7 mm-0° endoscope, and heats recorded at 100% and 50% light intensities were 37.8 °C and 35.3 °C, respectively. CONCLUSION: Stationary use of endoscopes with 3 mm and smaller calipers without irrigation or aspiration, the heat in the middle ear would appear to be safe, and at a level that does not cause thermal trauma to tissue. The present study demonstrates that frequent aspiration or intermittent irrigation may prevent potential thermal damage, even in procedures performed using endoscopes of a 4 mm caliper. Light intensity settings of 50% can be adopted as a further safety measure against potential thermal risk without compromising visual acuity.


Assuntos
Queimaduras/prevenção & controle , Endoscópios , Endoscopia/instrumentação , Complicações Intraoperatórias/prevenção & controle , Iluminação/instrumentação , Otite Média/cirurgia , Adolescente , Adulto , Queimaduras/etiologia , Doença Crônica , Endoscopia/efeitos adversos , Feminino , Humanos , Iluminação/efeitos adversos , Masculino , Pessoa de Meia-Idade , Miringoplastia/efeitos adversos , Miringoplastia/instrumentação , Adulto Jovem
11.
Int J Pediatr Otorhinolaryngol ; 109: 31-35, 2018 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-29728180

RESUMO

OBJECTIVE: The use of Mesna as a chemical dissector in higher concentrations may reduce the length of time of operation by providing more effective dissection as well as being used in otologic pathologies such as tympanosclerosis. In this study, it was aimed to assess the effect of Mesna on the internal ear, which was applied intra-tympanically in higher concentrations than the conventional use. METHODS: Twenty-four female rats were included in our study. The rats were randomly divided into three groups (Group 1: Mesna 50%, Group 2: Mesna 100%, Group 3: Saline). At the beginning of the study, DPOAE and ABR measurements were carried out on every rat on days 7 and 14. At the end of the study, cochleas of the rats were excised and histopathological assessments were carried out. RESULTS: Basal values and DPOAE and ABR values on day 7 and 14 of Group 1, Group 2, and Group 3 were similar to each other. No significant difference was detected among the three groups in the histopathological assessment carried out at the end of the study. CONCLUSION: It was revealed by audiological and histopathological parameters that the use of Mesna at 50% and 100% concentrations did not create toxicity effects on the internal ear. Mesna would be more effective by being used in higher concentrations in audiological surgeries, that its duration of operation world reduce and could being used in different indications including tympanosclerosis.


Assuntos
Cóclea/efeitos dos fármacos , Mesna/administração & dosagem , Substâncias Protetoras/administração & dosagem , Animais , Limiar Auditivo/efeitos dos fármacos , Cóclea/anatomia & histologia , Relação Dose-Resposta a Droga , Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Feminino , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Ratos Sprague-Dawley
12.
Auris Nasus Larynx ; 45(2): 332-336, 2018 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-28711215

RESUMO

OBJECTIVE: In this study, changes occurring in the contractility capacity of the inferior turbinate and mucociliary clearance time due to the interruption of nasal air flow were examined. MATERIAL & METHODS: A total of 23 patients undergone total laryngectomy between June 2010 and June 2012 were included in the study. Acoustic rhinometry test was performed in the patients before and after 0.05% oxymetazoline nasal topical decongestant administration. In addition, saccharin test was applied in order to measure mucociliary clearance. The same measurements were repeated at the postoperative months 1, 6 and 12 and the data obtained were statistically compared. RESULTS: In evaluation of the patients' contractility capacity at MCA-1 and MCA-2, contractility capacity was found to be significantly decreased from the postoperative first month compared to the preoperative values. The contractility capacity at the postoperative 6th month was significantly lower than that of the postoperative first month. The contractility capacity at the postoperative 12th month was significantly lower than that of the postoperative 6th month. Mucociliary clearance time did not change significantly at the postoperative first month compared to the preoperative value, while this value was significantly decreased at the postoperative 6th month. No statistically significant difference was observed in mucociliary clearance between the postoperative 6th and 12th months. CONCLUSION: Contractility capacity of the inferior turbinate decrease over time in patients undergoing total laryngectomy. This indicates that the dysfunction developing in the nasal mucosal structure in the chronical absence of nasal air flow may be resulted from the decreased choncal contractility.


Assuntos
Laringectomia , Depuração Mucociliar/fisiologia , Mucosa Nasal/fisiopatologia , Período Pós-Operatório , Conchas Nasais/fisiopatologia , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Descongestionantes Nasais , Oximetazolina , Estudos Prospectivos , Rinometria Acústica , Sacarina
13.
J Craniofac Surg ; 28(8): e781-e785, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28938330

RESUMO

OBJECTIVE: The objectives of this study are to demonstrate the relationship between the thickness of the temporal scalp and body mass index (BMI), age, and sex, and to present the surgical technique which we perform in patients with a thick scalp. MATERIALS AND METHODS: This is a retrospective, cross-sectional study. This study was performed in a tertiary referral center. Cranial computed tomography images of 469 subjects were included in the study. These subjects were evaluated according to BMI, age, and sex. These individuals were divided into 6 groups based on the BMI levels. Differences between the groups were compared in terms of temporal scalp thickness. In 5 patients with a mean scalp thickness of 9.7 mm, the receiver coil was placed over the temporal muscle fascia through a transmuscular incision without surgical thinning of the skin flap. RESULTS: Average scalp thickness was measured as significantly higher in males than in females, with advancing age, and increasing levels of BMI. In 5 adult patients with a scalp thickness measured as ≥7 mm who underwent cochlear implantation, suprafacial placement of the receiver coil achieved successful surgical and audiological results. CONCLUSION: Thinning of the skin flap is recommended in patients with a scalp thickness ≥ 7 mm to provide effective transmission, minimalized power requirement, and magnet retention. Suprafascial placement of the receiver coil can be recommended in patients with a thick scalp without any excisional thinning impairing integrity and vascularity of the skin.


Assuntos
Implante Coclear/métodos , Implantes Cocleares , Couro Cabeludo/cirurgia , Transplante de Pele/métodos , Retalhos Cirúrgicos/cirurgia , Adulto , Índice de Massa Corporal , Estudos Transversais , Feminino , Humanos , Masculino , Estudos Retrospectivos
14.
Int J Pediatr Otorhinolaryngol ; 100: 132-136, 2017 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-28802357

RESUMO

OBJECTIVE: Methotrexate is a dihydrofolate reductase enzyme inhibitor with very high selectivity, and it is an antiproliferative folic acid antagonist used for the treatment of autoimmune diseases. In this study, our objective was to evaluate the effect of intratympanic Methotrexate application in the inner ear. METHODS: This study was planned as an animal study. This study performed in a tertiary referral center. 24 healthy female rats were used in our study. They were separated into three groups. 0.2 cc intratympanic saline was applied to both ears of Group 1. Paracentesis was applied to the tympanic membrane in both ears of Group 2. 0.2 cc intratympanic Methotrexate was applied to both ears of Group 3. At the beginning of the study, Distortion-product otoacoustic emissions (DPOAE) and Auditory brainstem response (ABR) of all rats were measured and then again on the 5th, 10th and 15th day. Histologic examinations of all groups were compared. RESULTS: There was not any significant difference between basal DPOAE and ABR measurement values of the groups and the results were measured again on the 5th, 10th and 15th day (p > 0.05). There was no difference between the groups in terms of histology. CONCLUSION: The intratympanic Methotrexate injection does not have any ototoxic effect on inner ear. We assume that intratympanic Methotrexate could be used safely on inner ear diseases in which steroid treatment is contraindicated or not effective.


Assuntos
Otopatias/induzido quimicamente , Antagonistas do Ácido Fólico/efeitos adversos , Metotrexato/efeitos adversos , Membrana Timpânica/efeitos dos fármacos , Animais , Potenciais Evocados Auditivos do Tronco Encefálico/efeitos dos fármacos , Feminino , Antagonistas do Ácido Fólico/farmacologia , Metotrexato/farmacologia , Emissões Otoacústicas Espontâneas/efeitos dos fármacos , Ratos , Membrana Timpânica/patologia
15.
J Craniofac Surg ; 28(1): e94-e96, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27997451

RESUMO

OBJECTIVE: It was revealed that the thiol compound named mesna chemically softens the connective tissue with submucosal injection, and facilitates the endoscopic submucosal dissection. The authors aimed to investigate the effect of mesna injection on mucoperichondrial elevation during septoplasty operation. METHODS: This study was planned as a patient-control study and performed. Fifty-six patients who had septoplasty operation were divided into 2 groups that are submucosal mesna (group 1) and submucosal saline (group 2) applied ones. In both groups, the measurement was initiated by a timer during the start of septal incision and elevation processes. After bilateral subperichondrial and subperiostal elevation were finished, timer was stopped and time was recorded. After that, mucosal integrity was reviewed and mucosal damage status was recorded. The difficulty of mucoperichondrial elevation for the surgeon was recorded for each patient. RESULTS: Twenty-five (44.7%) of the patients who participated in our study were females while 31 (55.3%) were males. The average elevation periods were 201.4 ±â€Š74.3 seconds in group 1 and 260.2 ±â€Š84.1 seconds in group 2. In mesna applied patients, elevation period was statistically and significantly shorter (P = 0.009). Impairment in mucosal integrity was observed as 33.3% in group 1 and 58.8% in group 2. In mesna applied patients, significantly less impairment in mucosal integrity was observed (P = 0.031). The average mucoperichondrial elevation difficulty for the surgeon is observed as 4.83 ±â€Š2.47 in group 1 and 6.5 ±â€Š1.9 in group 2. Mesna applied patients were defined as significantly easier patients for the surgeon (P = 0.006). CONCLUSION: Submucosal mesna application is an approach that provides a convenient, fast, and effective mucoperichondrial elevation in septoplasty and protects the mucosal integrity.


Assuntos
Expectorantes/uso terapêutico , Mesna/uso terapêutico , Mucosa Nasal/efeitos dos fármacos , Septo Nasal/cirurgia , Adolescente , Adulto , Idoso , Feminino , Humanos , Injeções , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Rinoplastia/métodos , Adulto Jovem
16.
J Craniofac Surg ; 28(1): 56-60, 2017 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-27893549

RESUMO

OBJECTIVE: This study was conducted to investigate subclinical electrophysiological deleterious effect due to microtrauma to the nerve in response to the dissection of a tumor and parotid tissue from the facial nerve and its branches and surgical traction experienced during the operation. METHODS: The study included 34 adult patients who underwent parotidectomy operations under intraoperative facial nerve monitoring. Three measurements were taken from each patient to evaluate facial nerve functions, with 3 stimuli of different intensities applied with different timing. An initial stimulus of 1 mA was applied to confirm the identification of the main trunk of the facial nerve (Group 1: Initial-Normal). Then, a threshold value was found by stimulating the main trunk until muscle fasciculations were observed on facial muscles (Group 2: Basal-Minimal). The same procedure was repeated after the tumor was resected (Group 3: Final-Minimal). RESULTS: There was no significant difference between the stimulus thresholds of Group 2 (0.31 mA) and Group 3 (0.30 mA). The highest amplitude in all 3 groups was observed at the mental branch, and the lowest at the frontal. The highest latency value was measured at the frontal branch and the lowest at the mental branch. Five (14.7%) of the patients developed postoperative pareses that was completely resolved by the seventh postoperative day visit in these patients. CONCLUSION: This study demonstrated that the surgical trauma of a meticulously conducted dissection and surgical traction did not cause any deleterious electrophysiological alteration on the facial nerve.


Assuntos
Dissecação/métodos , Traumatismos do Nervo Facial/fisiopatologia , Traumatismos do Nervo Facial/cirurgia , Nervo Facial/fisiopatologia , Nervo Facial/cirurgia , Complicações Intraoperatórias/fisiopatologia , Monitorização Neurofisiológica Intraoperatória , Glândula Parótida/cirurgia , Neoplasias Parotídeas/cirurgia , Adulto , Músculos Faciais/inervação , Traumatismos do Nervo Facial/etiologia , Paralisia Facial/fisiopatologia , Feminino , Humanos , Complicações Intraoperatórias/cirurgia , Masculino , Pessoa de Meia-Idade , Glândula Parótida/inervação , Complicações Pós-Operatórias/fisiopatologia , Remissão Espontânea
17.
Otolaryngol Head Neck Surg ; 155(4): 714-7, 2016 10.
Artigo em Inglês | MEDLINE | ID: mdl-27406706

RESUMO

We evaluated the efficacy of interpositional auricular cartilage grafting for perforation with an endoscopic endonasal approach via a mucosal regeneration technique. In total, 12 patients with symptomatic septal perforations were operated on by way of an endoscopic endonasal approach after an adequately sized cartilage graft was harvested. The graft was inserted between the circumferentially incised and elevated flaps of the perforation and secured by vertical and horizontal nonabsorbable aligning approximation stitches and prolonged placement of silicone splints. The average perforation size was 12.3 mm (range, 4-19 mm). Bleeding, incrustation, pain, whistling respiration, and nasal congestion symptoms were relieved entirely in 10 of 12 patients (83.3%) who had successful treatment. This study showed that an endoscopic endonasal approach via a mucosal regeneration technique without direct mucosa-to-mucosa repair can be applied successfully without disrupting the neighboring nasal structures for septal perforations up to 20 mm and as effectively as other, more complex surgical interventions.


Assuntos
Cartilagem da Orelha/transplante , Endoscopia/métodos , Perfuração do Septo Nasal/cirurgia , Rinoplastia/métodos , Adolescente , Adulto , Feminino , Humanos , Masculino , Mucosa Nasal/cirurgia , Estudos Retrospectivos , Resultado do Tratamento , Cicatrização
18.
Auris Nasus Larynx ; 43(6): 637-40, 2016 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-27036360

RESUMO

OBJECTIVE: One of the most frequent reasons of nasal obstruction and sleep apnea in pediatrics is adenoid hypertrophy. Remaining adenoid tissue can reoccur following hypertrophied adenoid removal and a second operation may be needed. Nasal corticosteroids are utilized in order to reduce adenoid hypertrophy and eliminate adenoidectomy operation. The purpose of our study is to assess the effect of nasal corticosteroid administration after adenoidectomy on adenoid regrowth and symptom scores. MATERIAL AND METHOD: Seventy patients who had adenoidectomy were enrolled in our study. Patients were divided into two groups. Group I (35 patients) received Mometasone furoate (40mcg/day per nostril) intranasal spray for 6 months, starting at postoperative week 3 after wound healing. As for Group II (35 patients), they received intranasal saline spray. Patients were followed up for one year. Every patient had flexible nasal endoscopy at postoperative week 3 and one year after the operation. Choana was scored according to its occlusion level by the adenoid tissue. Additionally, nasal obstruction symptoms (nasal congestion, dry mouth, snoring, nasal speaking, apnea and night coughing) were scored. RESULTS: Remaining adenoid tissue in the nasopharynx was comparable in flexible endoscopic assessment and no significant difference was seen between postoperative week 3 nasal obstruction scores. In the flexible endoscopic assessment completed in the twelfth month of the study, significant reduction was found in Group 1 compared to Group 2 in terms of adenoid size. When patients in both groups were compared, statistically significant reduction was observed in nasal obstruction symptom scores at the twelfth month. CONCLUSION: This study has demonstrated that the use of steroid nasal spray following adenoidectomy significantly prevents regrowth and reduces nasal obstruction symptoms in the early period.


Assuntos
Adenoidectomia , Tonsila Faríngea/cirurgia , Glucocorticoides/uso terapêutico , Furoato de Mometasona/uso terapêutico , Obstrução Nasal/cirurgia , Tonsila Faríngea/patologia , Administração Intranasal , Criança , Pré-Escolar , Estudos Transversais , Feminino , Humanos , Hipertrofia/complicações , Hipertrofia/prevenção & controle , Hipertrofia/cirurgia , Lactente , Masculino , Obstrução Nasal/etiologia , Obstrução Nasal/prevenção & controle , Sprays Nasais , Cuidados Pós-Operatórios/métodos , Recidiva , Cloreto de Sódio/uso terapêutico
19.
Eur Arch Otorhinolaryngol ; 273(11): 3759-3764, 2016 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-27115909

RESUMO

Aims of this study are to analyze the association of the anterior ethmoidal artery's (AEA) visualization with variations in its adjacent structures in coronal, axial, and sagittal CT images, to assess its relation with the ethmoid roof, and, based on this relation, to introduce a new classification for the ethmoid roof. A retrospective, cross-sectional study was performed in a tertiary referral center. In this retrospective, cross-sectional study, the coronal, axial, and sagittal CTs of 184 patients have been surveyed and the AEA canal, the ethmoid roof, and their relations with surrounding structures have been assessed. The Keros classification used to measure the depth of the lateral lamella of the cribriform plate (LLCP) in the ethmoid roof has been modified to include anterior-posterior length of the LLCP. It was shown that the visualization of the AEA canal increases in a statistically significant manner with an increase in the superior-inferior depth and the anterior-posterior length of the LLCP bilaterally. In the presence of supraorbital pneumatization, AEA visualization was shown to increase bilaterally significantly. This study demonstrated a positive correlation between the AEA canal, the LLCP superior-inferior depth, and the anterior-posterior length. It was shown that with the increased depth and length of the LLCP and in the presence of supraorbital pneumatization, the visualization of the artery and hence the injury risks are increased. The LLCP anterior-posterior length is as clinically relevant as is its depth, and a radiologic classification has been defined according to the anterior-posterior length of the LLCP.


Assuntos
Osso Etmoide/anatomia & histologia , Seio Etmoidal/irrigação sanguínea , Artéria Oftálmica/anatomia & histologia , Tomografia Computadorizada por Raios X , Adolescente , Adulto , Idoso , Estudos Transversais , Osso Etmoide/irrigação sanguínea , Osso Etmoide/diagnóstico por imagem , Seio Etmoidal/anatomia & histologia , Seio Etmoidal/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Artéria Oftálmica/diagnóstico por imagem , Estudos Retrospectivos , Adulto Jovem
20.
JAMA Facial Plast Surg ; 18(3): 157-63, 2016 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-26914594

RESUMO

BACKGROUND: Edema persists for months after rhinoplasty. Numerous modalities have been described to counteract postoperative edema. OBJECTIVE: To evaluate the effect of postrhinoplasty taping (PRT) on nasal edema and nasal draping. DESIGN, SETTING, AND PARTICIPANTS: In this randomized clinical trial, 57 patients undergoing rhinoplasty at a tertiary reference center from August 1, 2014, to January 31, 2015, were assigned to a control group or to 2- or 4-week PRT groups. Baseline nasal thickness was measured with ultrasonography at the nasion, rhinion, supratip, and tip, and mean nasal skin thickness (MNST) was calculated. Participants in each group were categorized by the baseline MNST measurement from the lowest to greatest MNST; those in the upper half were categorized as having thick skin; those in the lower half, thin skin. The control group underwent no PRT after the removal of external packing. Patients in the 2- and 4-week PRT groups received additional taping during the allocated time. Data were collected from August 1, 2014, to June 31, 2015. Follow-up was completed on June 31, 2015, and data were analyzed from July 1 to August 1, 2015. MAIN OUTCOMES AND MEASURES: Postoperative measurements of MNST were performed at the end of weeks 1, 3, and 5 and month 6. RESULTS: Of the 57 total patients (33 male and 24 female patients; mean [SD] age, 30.0 [11.7] years), 17 were in the 2-week PRT group; 20, the 4-week PRT group; and 20, the control group. Compared with the control group, 4-week PRT had a significant effect on the supratip (P = .001). Comparisons of MNST with the control group revealed significant effects of 2-week (P = .02) and 4-week (P = .007) PRT. The effect on the tip was not significant (P = .052). Postrhinoplasty taping had no effect in thin-skinned patients. Comparison among thick-skinned patients revealed a significant effect on the MNST (P = .01) and the rhinion (P = .02) but not the tip (P = .06) and supratip (P = .07). CONCLUSIONS AND RELEVANCE: Postrhinoplasty taping helps the skin envelope to compress to the underlying framework and decrease postoperative edema. The procedure can be used particularly in thick-skinned patients, in whom skin draping and nasal refinement is crucial to the surgical outcome. LEVEL OF EVIDENCE: 1. TRIAL REGISTRATION: clinicaltrials.gov Identifier: NCT02626585.


Assuntos
Bandagens Compressivas , Edema/diagnóstico por imagem , Edema/terapia , Nariz/diagnóstico por imagem , Rinoplastia/métodos , Adulto , Feminino , Humanos , Masculino , Nariz/cirurgia , Período Pós-Operatório , Pele/diagnóstico por imagem , Ultrassonografia , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...