RESUMO
Generation of ROS (including free radicals) in rat platelets during physical exercises of different intensities was evaluated by the chemiluminescent method. The acute or chronic submaximal exercises increased the platelet chemiluminescence by 2.5-3.0 times. In the control, platelet activation with physiological aggregant ADP enhanced their chemiluminescence by 7.5 times. Addition of ADP to platelets isolated from animals subjected to exercise of any intensity increased chemiluminescence by 4-5 times. In a trained organism, functional reserve of the platelets is preserved during long-term physical exercise of any intensity, but is exhausted after acute physical exercise. Thus, intensive physical exercises enhanced the hemostatic potential of the blood, which is associated with the risk of thrombohemorrhagic complications, especially in acute or submaximal long-term exercises.
Assuntos
Plaquetas/fisiologia , Luminescência , Condicionamento Físico Animal/fisiologia , Animais , Animais não Endogâmicos , Radicais Livres/metabolismo , Masculino , Condicionamento Físico Animal/métodos , Esforço Físico/fisiologia , Ativação Plaquetária/fisiologia , Ratos , Espécies Reativas de Oxigênio/metabolismo , Natação/fisiologiaRESUMO
Chronic submaximal physical load of aerobic-anaerobic charater leads to pro-atherogenic dyslipidemia, as manifested by increased levels of triglycerides, total cholesterol, and very-low-density lipoproteins. Ceruloplasmin (total dose 60 mg/kg body weight, triple intraperitoneal introduction on the 1st, 3rd, and 5th day of experiment) produced a partial correction of dyslipidemia, manifested by restoration of the normal levels of triglycerides, total cholesterol, and lipoproteins of very low, low, and high density. At the same time, ceruloplasmin administration did not influence the level of phospholipids.
Assuntos
Ceruloplasmina/farmacologia , Dislipidemias , Lipídeos/sangue , Condicionamento Físico Animal/efeitos adversos , Animais , Dislipidemias/sangue , Dislipidemias/tratamento farmacológico , Dislipidemias/etiologia , RatosRESUMO
Acute physical exercise was followed by a decrease in the osmotic resistance of erythrocytes, shortening of the time-to-onset of erythrocyte hemolysis, and increase in the sorption capacity of the cell membrane. Administration of ceruloplasmin 24 h before physical exercise normalizes membrane resistance in red blood cells.
