RESUMO
PURPOSE: To increase the RF coil performance and RF management for body imaging at 10.5 T by validating and evaluating a high-density 16-channel transceiver array, implementing virtual observation points (VOPs), and demonstrating specific absorption rate (SAR) constrained imaging in vivo. METHODS: The inaccuracy of the electromagnetic model of the array was quantified based on B1 + and SAR data. Inter-subject variability was estimated using a new approach based on the relative SAR deviation of different RF shims between human body models. The pTx performance of the 16-channel array was assessed in simulation by comparison to a previously demonstrated 10-channel array. In vivo imaging of the prostate was performed demonstrating SAR-constrained static RF shimming and acquisition modes optimized for refocused echoes (AMORE). RESULTS: The model inaccuracy of 29% and the inter-subject variability of 85% resulted in a total safety factor of 1.91 for pelvis studies. For renal and cardiac imaging, inter-subject variabilities of 121% and 141% lead to total safety factors of 2.25 and 2.45, respectively. The shorter wavelength at 10.5 T supported the increased element density of the 16-channel array which in turn outperformed the 10-channel version for all investigated metrics. Peak 10 g local SAR reduction of more than 25% without a loss of image quality was achieved in vivo, allowing a theoretical improvement in measurement efficiency of up to 66%. CONCLUSIONS: By validating and characterizing a 16-channel dipole transceiver array, this work demonstrates, for the first time, a VOP-enabled RF coil for human torso imaging enabling increased pTx performance at 10.5 T.
Assuntos
Imageamento por Ressonância Magnética , Próstata , Masculino , Humanos , Imageamento por Ressonância Magnética/métodos , Imagens de Fantasmas , Desenho de Equipamento , Simulação por Computador , Ondas de RádioRESUMO
PURPOSE: To propose a single setup using the MRI to both measure and validate the transfer function (TF) of linear implants. Conventionally, the TF of an implant is measured in one bench setup and validated using another. METHODS: It has been shown that the TF can be measured using MRI. To validate this measurement, the implant is exposed to different incident electric fields, while the temperature increase at the tip is monitored. For a good validation, the incident electric fields that the implant is exposed to should be orthogonal. We perform a simulation study on six different methods that change the incident electric field. Afterward, a TF measurement and validation study using the best method from the simulations is performed. This is done with fiberoptic temperature probes at 1.5 T for four linear implant structures using the proposed single setup. RESULTS: The simulation study showed that positioning local transmit coils at different locations along the lead trajectory has a similar validation quality compared with changing the implant trajectory (ie, the conventional validation method). For the validation study that was performed, an R2 ≥ 0.91 was found for the four investigated leads. CONCLUSION: A single setup to both measure and validate the transfer function using local transmit coils has been shown to work. The benefits of using the proposed validation method are that there is only one setup required instead of two and the implant trajectory is not varied; therefore, the relative distance between the leap tip and the temperature probe is constant.
Assuntos
Campos Eletromagnéticos , Ondas de Rádio , Imageamento por Ressonância Magnética , Imagens de Fantasmas , Próteses e ImplantesRESUMO
PURPOSE: This study investigates the implications of all degrees of freedom of within-scan patient head motion on patient safety. METHODS: Electromagnetic simulations were performed by displacing and/or rotating a virtual body model inside an 8-channel transmit array to simulate 6 degrees of freedom of motion. Rotations of up to 20° and displacements of up to 20 mm including off-axis axial/coronal translations were investigated, yielding 104 head positions. Quadrature excitation, RF shimming, and multi-spoke parallel-transmit excitation pulses were designed for axial slice-selection at 7T, for seven slices across the head. Variation of whole-head specific absorption rate (SAR) and 10-g averaged local SAR of the designed pulses, as well as the change in the maximum eigenvalue (worst-case pulse) were investigated by comparing off-center positions to the central position. RESULTS: In their respective worst-cases, patient motion increased the eigenvalue-based local SAR by 42%, whole-head SAR by 60%, and the 10-g averaged local SAR by 210%. Local SAR was observed to be more sensitive to displacements along right-left and anterior-posterior directions than displacement in the superior-inferior direction and rotation. CONCLUSION: This is the first study to investigate the effect of all 6 degrees of freedom of motion on safety of practical pulses. Although the results agree with the literature for overlapping cases, the results demonstrate higher increases (up to 3.1-fold) in local SAR for off-axis displacement in the axial plane, which had received less attention in the literature. This increase in local SAR could potentially affect the local SAR compliance of subjects, unless realistic within-scan patient motion is taken into account during pulse design.
Assuntos
Cabeça , Imageamento por Ressonância Magnética , Simulação por Computador , Cabeça/diagnóstico por imagem , Humanos , Imagens de Fantasmas , CintilografiaRESUMO
INTRODUCTION: MRI gradient-fields may induce extrinsic voltage between electrodes and conductive neurostimulator enclosure of implanted deep brain stimulation (DBS) systems, and may cause unintended stimulation and/or malfunction. Electromagnetic (EM) simulations using detailed anatomical human models, therapy implant trajectories, and gradient coil models can be used to calculate clinically relevant induced voltage levels. Incorporating additional anatomical human models into the EM simulation library can help to achieve more clinically relevant and accurate induced voltage levels, however, adding new anatomical human models and developing implant trajectories is time-consuming, expensive and not always feasible. METHODS: MRI gradient-field induced voltage levels are simulated in six adult human anatomical models, along clinically relevant DBS implant trajectories to generate the dataset. Predictive artificial neural network (ANN) regression models are trained on the simulated dataset. Leave-one-out cross validation is performed to assess the performance of ANN regressors and quantify model prediction errors. RESULTS: More than 180,000 unique gradient-induced voltage levels are simulated. ANN algorithm with two fully connected layers is selected due to its superior generalizability compared to support vector machine and tree-based algorithms in this particular application. The ANN regression model is capable of producing thousands of gradient-induced voltage predictions in less than a second with mean-squared-error less than 200 mV. CONCLUSION: We have integrated machine learning (ML) with computational modeling and simulations and developed an accurate predictive model to determine MRI gradient-field induced voltage levels on implanted DBS systems.
RESUMO
PURPOSE: To investigate the feasibility of imaging the human torso and to evaluate the performance of several radiofrequency (RF) management strategies at 10.5T. METHODS: Healthy volunteers were imaged on a 10.5T whole-body scanner in multiple target anatomies, including the prostate, hip, kidney, liver, and heart. Phase-only shimming and spoke pulses were used to demonstrate their performance in managing the B1+ inhomogeneity present at 447 MHz. Imaging protocols included both qualitative and quantitative acquisitions to show the feasibility of imaging with different contrasts. RESULTS: High-quality images were acquired and demonstrated excellent overall contrast and signal-to-noise ratio. The experimental results matched well with predictions and suggested good translational capabilities of the RF management strategies previously developed at 7T. Phase-only shimming provided increased efficiency, but showed pronounced limitations in homogeneity, demonstrating the need for the increased degrees of freedom made possible through single- and multispoke RF pulse design. CONCLUSION: The first in-vivo human imaging was successfully performed at 10.5T using previously developed RF management strategies. Further improvement in RF coils, transmit chain, and full integration of parallel transmit functionality are needed to fully realize the benefits of 10.5T.
Assuntos
Interpretação de Imagem Assistida por Computador , Imageamento por Ressonância Magnética , Coração , Humanos , Masculino , Ondas de Rádio , Razão Sinal-RuídoRESUMO
The potential value of ultrahigh field (UHF) magnetic resonance imaging (MRI) and spectroscopy to biomedical research and in clinical applications drives the development of technologies to overcome its many challenges. The increased difficulties of imaging the human torso compared with the head include its overall size, the dimensions and location of its anatomic targets, the increased prevalence and magnitude of physiologic effects, the limited availability of tailored RF coils, and the necessary transmit chain hardware. Tackling these issues involves addressing notoriously inhomogeneous transmit B1 (B1) fields, limitations in peak B1, larger spatial variations of the static magnetic field B0, and patient safety issues related to implants and local RF power deposition. However, as research institutions and vendors continue to innovate, the potential gains are beginning to be realized. Solutions overcoming the unique challenges associated with imaging the human torso are reviewed as are current studies capitalizing on the benefits of UHF in several anatomies and applications. As the field progresses, strategies associated with the RF system architecture, calibration methods, RF pulse optimization, and power monitoring need to be further integrated into the MRI systems making what are currently complex processes more streamlined. Meanwhile, the UHF MRI community must seize the opportunity to build upon what have been so far proof of principle and feasibility studies and begin to further explore the true impact in both research and the clinic.
Assuntos
Imageamento por Ressonância Magnética/métodos , Tronco/diagnóstico por imagem , Humanos , Imageamento por Ressonância Magnética/efeitos adversos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/tendências , Ondas de RádioRESUMO
PURPOSE: To validate electromagnetic and thermal simulations with in vivo temperature measurements, and to demonstrate a framework that can be used to predict temperature increase caused by radiofrequency (RF) excitation with dipole transmitter arrays. METHODS: Dipole arrays were used to deliver RF energy in the back/neck region of the swine using different RF excitation patterns (n = 2-4 per swine) for heating. The temperature in anesthetized swine (n = 3) was measured using fluoroscopic probes (n = 12) and compared against thermal modeling from animal-specific electromagnetic simulations. RESULTS: Simulated temperature curves were in agreement with the measured data. The root mean square error between simulated and measured temperature rise at all locations (at the end of each RF excitation) is calculated as 0.37°C. The mean experimental temperature rise at the maximum temperature rise locations (averaged over all experiments) is calculated as 2.89°C. The root mean square error between simulated and measured temperature at the maximum temperature rise location is calculated as 0.57°C. (Error values are averaged over all experiments.) CONCLUSIONS: Electromagnetic and thermal simulations were validated with experiments. Thermal effects of RF excitation at 10.5 Tesla with dipoles were investigated. Magn Reson Med 79:479-488, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
Assuntos
Desenho de Equipamento , Temperatura Alta , Hipertermia Induzida/instrumentação , Ondas de Rádio , Animais , Calibragem , Simulação por Computador , Campos Eletromagnéticos , Radiação Eletromagnética , Imageamento por Ressonância Magnética , Espectroscopia de Ressonância Magnética , Modelos Anatômicos , Imagens de Fantasmas , Suínos , Tomografia Computadorizada por Raios XRESUMO
PURPOSE: To develop a 16-channel transceive body imaging array at 7.0 T with improved transmit, receive, and specific absorption rate (SAR) performance by combining both loop and dipole elements and using their respective and complementary near and far field characteristics. METHODS: A 16-channel radiofrequency (RF) coil array consisting of eight loop-dipole blocks (16LD) was designed and constructed. Transmit and receive performance was quantitatively investigated in phantom and human model simulations, and experiments on five healthy volunteers inside the prostate. Comparisons were made with 16-channel microstrip line (16ML) and 10-channel fractionated dipole antenna (10DA) arrays. The 16LD was used to acquire anatomic and functional images of the prostate, kidneys, and heart. RESULTS: The 16LD provided > 14% improvements in the signal-to-noise ratio (SNR), peak B1+, B1+ transmit, and SAR efficiencies over the 16ML and 10DA in simulations inside the prostate. Experimentally, the 16LD had > 20% higher SNR and B1+ transmit efficiency compared with other arrays, and achieved up to 51.8% higher peak B1+ compared with 10DA. CONCLUSION: Combining loop and dipole elements provided a body imaging array with high channel count and density while limiting inter-element coupling. The 16LD improved both near and far-field performance compared with existing 7.0T body arrays and provided high-quality MRI of the prostate kidneys and heart. Magn Reson Med 77:884-894, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Assuntos
Processamento de Imagem Assistida por Computador/métodos , Imagem Cinética por Ressonância Magnética/instrumentação , Imagem Cinética por Ressonância Magnética/métodos , Algoritmos , Desenho de Equipamento , Coração/diagnóstico por imagem , Humanos , Rim/diagnóstico por imagem , Masculino , Imagens de Fantasmas , Próstata/diagnóstico por imagemRESUMO
PURPOSE: To explore the potential of performing body imaging at 10.5 Tesla (T) compared with 7.0T through evaluating the transmit/receive performance of similarly configured dipole antenna arrays. METHODS: Fractionated dipole antenna elements for 10.5T body imaging were designed and evaluated using numerical simulations. Transmit performance of antenna arrays inside the prostate, kidneys and heart were investigated and compared with those at 7.0T using both phase-only radiofrequency (RF) shimming and multi-spoke pulses. Signal-to-noise ratio (SNR) comparisons were also performed. A 10-channel antenna array was constructed to image the abdomen of a swine at 10.5T. Numerical methods were validated with phantom studies at both field strengths. RESULTS: Similar power efficiencies were observed inside target organs with phase-only shimming, but RF nonuniformity was significantly higher at 10.5T. Spokes RF pulses allowed similar transmit performance with accompanying local specific absorption rate increases of 25-90% compared with 7.0T. Relative SNR gains inside the target anatomies were calculated to be >two-fold higher at 10.5T, and 2.2-fold SNR gain was measured in a phantom. Gradient echo and fast spin echo imaging demonstrated the feasibility of body imaging at 10.5T with the designed array. CONCLUSION: While comparable power efficiencies can be achieved using dipole antenna arrays with static shimming at 10.5T; increasing RF nonuniformities underscore the need for efficient, robust, and safe parallel transmission methods. Magn Reson Med 77:434-443, 2017. © 2016 International Society for Magnetic Resonance in Medicine.
Assuntos
Simulação por Computador , Processamento de Imagem Assistida por Computador/métodos , Imageamento por Ressonância Magnética/instrumentação , Imageamento por Ressonância Magnética/métodos , Imagem Corporal Total/métodos , Adulto , Animais , Desenho de Equipamento , Feminino , Humanos , Masculino , Modelos Anatômicos , Imagens de Fantasmas , SuínosRESUMO
Purpose To develop and demonstrate in vitro and in vivo a single interventional magnetic resonance (MR)-active device that integrates the functions of precise identification of a tissue site with the delivery of radiofrequency (RF) energy for ablation, high-spatial-resolution thermal mapping to monitor thermal dose, and quantitative MR imaging relaxometry to document ablation-induced tissue changes for characterizing ablated tissue. Materials and Methods All animal studies were approved by the institutional animal care and use committee. A loopless MR imaging antenna composed of a tuned microcable either 0.8 or 2.2 mm in diameter with an extended central conductor was switched between a 3-T MR imaging unit and an RF power source to monitor and perform RF ablation in bovine muscle and human artery samples in vitro and in rabbits in vivo. High-spatial-resolution (250-300-µm) proton resonance frequency shift MR thermometry was interleaved with ablations. Quantitative spin-lattice (T1) and spin-spin (T2) relaxation time MR imaging mapping was performed before and after ablation. These maps were compared with findings from gross tissue examination of the region of ablated tissue after MR imaging. Results High-spatial-resolution MR imaging afforded temperature mapping in less than 8 seconds for monitoring ablation temperatures in excess of 85°C delivered by the same device. This produced irreversible thermal injury and necrosis. Quantitative MR imaging relaxation time maps demonstrated up to a twofold variation in mean regional T1 and T2 after ablation versus before ablation. Conclusion A simple, integrated, minimally invasive interventional probe that provides image-guided therapy delivery, thermal mapping of dose, and detection of ablation-associated MR imaging parametric changes was developed and demonstrated. With this single-device approach, coupling-related safety concerns associated with multiple conductor approaches were avoided. © RSNA, 2016 Online supplemental material is available for this article.
Assuntos
Ablação por Cateter/instrumentação , Termografia/instrumentação , Animais , Aorta/anatomia & histologia , Aorta/fisiologia , Aorta/cirurgia , Bovinos , Vasos Coronários/anatomia & histologia , Vasos Coronários/fisiologia , Vasos Coronários/cirurgia , Temperatura Alta , Humanos , Imagem por Ressonância Magnética Intervencionista , Músculo Esquelético/anatomia & histologia , Músculo Esquelético/fisiologia , Músculo Esquelético/cirurgia , Coelhos , Artéria Renal/anatomia & histologia , Artéria Renal/fisiologia , Artéria Renal/cirurgia , SuínosRESUMO
PURPOSE: To develop and evaluate a sterilizable multichannel endorectal coil (ERC) for use in combination with an external surface array (ESA) for high-resolution anatomical and functional studies of the prostate at 7T. MATERIALS AND METHODS: A two-loop ERC (ERC-2L) and a microstrip-loop ERC (ERC-ML) were compared at 7T in terms of transmit and receive performance. The best-performing ERC was evaluated alone and in combination with the ESA through 1) simulations on both phantom and an anatomically correct numerical human model to assess B1+ transmit and specific absorption rate (SAR) efficiencies, and 2) phantom experiments to calculate B1+ transmit efficiency and signal-to-noise ratio (SNR). Phantom studies were also performed to look at heating when using the ERC as a transmitter and for comparing the new coil against a single-channel balloon-type ERC (ERC-b). High-resolution magnetic resonance imaging (MRI) acquisitions were performed on a single healthy subject using the two-channel ERC combined with the ESA. RESULTS: Compared to the ERC-ML, the ERC-2L demonstrated 20% higher SAR efficiency and higher SNR 3 cm from the coil. The presence of a tuned and detuned ERC-2L did not alter the peak local SAR of the ESA alone; however, the detuned ERC-2L had 45% less peak local SAR around the rectum compared to the tuned ERC-2L. The receive-only version of the ERC-2L improved the SNR 4.7-fold and 1.3-fold compared to the ESA and ERC-b, respectively. In combination with the ESA, the ERC-2L supported in-plane voxel-size of 0.36 × 0.36 mm(2) in T2 -weighted anatomic imaging. CONCLUSION: The reusable ERC-2L combined with an ESA offers a high SNR imaging platform for translational studies of the prostate at 7T. J. Magn. Reson. Imaging 2016;43:1279-1287.
Assuntos
Aumento da Imagem/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Neoplasias da Próstata/diagnóstico por imagem , Transdutores , Desenho Assistido por Computador , Desenho de Equipamento , Análise de Falha de Equipamento , Humanos , Magnetismo/instrumentação , Masculino , Imagens de Fantasmas , Neoplasias da Próstata/patologia , Reprodutibilidade dos Testes , Sensibilidade e EspecificidadeRESUMO
PURPOSE: Radiofrequency (RF) radiometry uses thermal noise detected by an antenna to measure the temperature of objects independent of medical imaging technologies such as magnetic resonance imaging (MRI). Here, an active interventional MRI antenna can be deployed as a RF radiometer to measure local heating, as a possible new method of monitoring device safety and thermal therapy. METHODS: A 128 MHz radiometer receiver was fabricated to measure the RF noise voltage from an interventional 3 T MRI loopless antenna and calibrated for temperature in a uniformly heated bioanalogous gel phantom. Local heating (ΔT) was induced using the antenna for RF transmission and measured by RF radiometry, fiber-optic thermal sensors, and MRI thermometry. The spatial thermal sensitivity of the antenna radiometer was numerically computed using a method-of-moment electric field analyses. The gel's thermal conductivity was measured by MRI thermometry, and the localized time-dependent ΔT distribution computed from the bioheat transfer equation and compared with radiometry measurements. A "H-factor" relating the 1 g-averaged ΔT to the radiometric temperature was introduced to estimate peak temperature rise in the antenna's sensitive region. RESULTS: The loopless antenna radiometer linearly tracked temperature inside a thermally equilibrated phantom up to 73 °C to within ±0.3 °C at a 2 Hz sample rate. Computed and MRI thermometric measures of peak ΔT agreed within 13%. The peak 1 g-average temperature was H = 1.36 ± 0.02 times higher than the radiometric temperature for any media with a thermal conductivity of 0.15-0.50 (W/m)/K, indicating that the radiometer can measure peak 1 g-averaged ΔT in physiologically relevant tissue within ±0.4 °C. CONCLUSIONS: Active internal MRI detectors can serve as RF radiometers at the MRI frequency to provide accurate independent measures of local and peak temperature without the artifacts that can accompany MRI thermometry or the extra space needed to accommodate alternative thermal transducers. A RF radiometer could be integrated in a MRI scanner to permit "self-monitoring" for assuring device safety and/or monitoring delivery of thermal therapy.
Assuntos
Temperatura Alta , Imagem por Ressonância Magnética Intervencionista , Ondas de Rádio , Radiometria/métodos , Imagens de Fantasmas , Radiometria/instrumentaçãoRESUMO
BACKGROUND: Many epidural and peripheral nerve catheters contain conducting wire that could heat during magnetic resonance imaging (MRI), requiring removal for scanning. METHODS: We tested 2 each of 6 brands of regional analgesia catheters (from Arrow International [Reading, Pennsylvania], B. Braun Medical Inc [Bethlehem, Pennsylvania], and Smiths Medical/Portex [Keene, New Hampshire]) for exposure to clinical 1.5- and 3-T MRI. Catheters testing as nonmagnetic were placed in an epidural configuration in a standard human torso-sized phantom, and an MRI pulse sequence applied at the maximum scanner-allowed radiofrequency specific absorption rate (SAR) for 15 minutes. Temperature and SAR exposure were sampled during MRI using multiple fiberoptic temperature sensors. RESULTS: Two catheters (the Arrow StimuCath Peripheral Nerve and B. Braun Medical Perifix FX Epidural) were found to be magnetic and not tested further. At 3 T, exposure of the remaining 3 epidural and 1 peripheral nerve catheter to the scanner's maximum RF exposure elicited anomalous heating of 4°C to 7°C in 2 Arrow Epidural (MultiPort and Flex-Tip Plus) catheters at the entry points. Temperature increases for the other catheters at 3 T, and all catheters at 1.5 T were 1.4°C or less. When normalized to the body-average US Food and Drug Administration guideline SAR of 4 W/kg, maximum projected temperature increases were 0.1°C to 2.5°C at 1.5 T and 0.7°C to 2.7°C at 3 T, except for the Arrow MultiPort Flex-Tip Plus catheter at 3 T whose increase was 14°C. CONCLUSIONS: Most but not all catheters can be left in place during 1.5-T MRI scans. Heating of less than 3°C during MRI for most catheters is not expected to be injurious. While heating was lower at 1.5 T versus 3 T, performance differences between products underscore the need for safety testing before performing MRI.
Assuntos
Cateterismo/instrumentação , Cateteres de Demora , Espaço Epidural , Imageamento por Ressonância Magnética/efeitos adversos , Nervos Periféricos , Temperatura , Cateterismo/métodos , Desenho de Equipamento , Análise de Falha de Equipamento , Imageamento por Ressonância Magnética/instrumentação , Teste de Materiais , Imagens de Fantasmas , Fatores de TempoRESUMO
PURPOSE: Use of external coils with internal detectors or conductors is challenging at 7 Tesla (T) due to radiofrequency (RF) field (B1 ) penetration, B1 -inhomogeneity, mutual coupling, and potential local RF heating. The present study tests whether the near-quadratic gains in signal-to-noise ratio and field-of-view with field-strength previously reported for internal loopless antennae at 7T can suffice to perform MRI with an interventional transmit/receive antenna without using any external coils. METHODS: External coils were replaced by semi-rigid or biocompatible transmit/receive loopless antennae requiring only a few Watts of peak RF power. Slice selection was provided by spatially selective B1 -insensitive composite RF pulses that compensate for the antenna's intrinsically nonuniform B1 -field. Power was adjusted to maintain local temperature rise ≤1°C. Fruit, intravascular MRI of diseased human vessels in vitro, and MRI of rabbit aorta in vivo are demonstrated. RESULTS: Scout MRI with the transmit/receive antennae yielded a ≤10 cm cylindrical field-of-view, enabling subsequent targeted localization at â¼100 µm resolution in 10-50 s and/or 50 µm MRI in â¼2 min in vitro, and 100-300 µm MRI of the rabbit aorta in vivo. CONCLUSION: A simple, low-power, one-device approach to interventional MRI at 7T offers the potential of truly high-resolution MRI, while avoiding issues with external coil excitation and interactions at 7T.
Assuntos
Aorta/anatomia & histologia , Aumento da Imagem/instrumentação , Imageamento por Ressonância Magnética/instrumentação , Animais , Simulação por Computador , Desenho de Equipamento , Estudos de Viabilidade , Coelhos , Ondas de RádioRESUMO
Improving the signal-to-noise-ratio (SNR) of magnetic resonance imaging (MRI) using denoising techniques could enhance their value, provided that signal statistics and image resolution are not compromised. Here, a new denoising method based on spectral subtraction of the measured noise power from each signal acquisition is presented. Spectral subtraction denoising (SSD) assumes no prior knowledge of the acquired signal and does not increase acquisition time. Whereas conventional denoising/filtering methods are compromised in parallel imaging by spatially dependent noise statistics, SSD is performed on signals acquired from each coil separately, prior to reconstruction. Using numerical simulations, we show that SSD can improve SNR by up to ~45% in MRI reconstructed from both single and array coils, without compromising image resolution. Application of SSD to phantom, human heart, and brain MRI achieved SNR improvements of ~40% compared to conventional reconstruction. Comparison of SSD with anisotropic diffusion filtering showed comparable SNR enhancement at low-SNR levels (SNR = 5-15) but improved accuracy and retention of structural detail at a reduced computational load.