[Syndrome of persistent generalized lymphadenopathy with development into a gastric lymphoma]. / Síndrome de las linfoadenopatías generalizadas persistentes con evolución a linfoma gástrico.

A man with previous addiction to parenteral drugs presented infection by human immunodeficiency virus (HIV) with persistent generalised lymph node enlargement. Sixteen months after diagnosis, he developed intermediate-grade lymphoma of the stomach. Partial response was achieved by chemotherapy, and the patient presented pulmonary and meningeal tuberculosis which led him to exitus.

Mental nerve neuropathy in systemic cancer. Report of three cases.

Mental nerve neuropathy (MNN), an uncommon neurologic symptom, was observed in three patients with cancer. In the first patient, MNN was the primary manifestation of an occult carcinoma of the lung. The second patient had bilateral MNN. In the third patient, MNN coexisted with symptomatic trigeminal neuralgia as a consequence of a cavum adenocarcinoma. A nontraumatic MNN must be considered a potentially ominous symptom that should prompt a search for cancer.

[Thrombopenic purpura associated with human immunodeficiency virus infection. Analysis of 24 cases]. / Púrpura trombopénica asociada a infección por virus de la inmunodeficiencia humana. Análisis de 24 casos.

In 24 cases of thrombopenic purpura associated with human immunodeficiency virus infection the clinical, immunological and therapeutic features were evaluated. Thrombopenia resulted in clinical manifestations in 20 patients. Splenomegaly was found in only one fourth of patients. Antiplatelet antibodies were found in 9 patients, and thrombopenia was associated with anemia in 37% of cases and with leukopenia in 21%. Bone marrow examination showed megakaryocyte hyperplasia in two thirds of the patients. The major immunological abnormalities were an inverted helper/suppressor T lymphocytes ratio, a reduction in the number of helper T lymphocytes, polyclonal hypergammaglobulinemia, and increased serum concentrations of circulating immunocomplexes. The different therapeutic modalities, steroids, vincristine, danatrol and plasma exchange, resulted in short responses; only two patients had normal platelet counts. The median follow-up was 14 months; during this time three patients fulfilled the criteria of acquired immunodeficiency syndrome.