1.
Bioorg Med Chem Lett
; 19(9): 2537-41, 2009 May 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19339180
RESUMO
Starting from a non-selective pyrazolo-pyrimidone lead, the sequential use of parallel medicinal chemistry and directed synthesis led to the discovery of potent, highly selective, and orally bioavailable PDE9 inhibitors. The availability of these tools allowed for a thorough evaluation of the therapeutic potential of PDE9 inhibition.