RESUMO
BACKGROUND: Metabolic Syndrome (MetS) is a clinical diagnosis where patients exhibit three out of the five risk factors: hypertriglyceridemia, low high-density lipoprotein (HDL) cholesterol, hyperglycemia, elevated blood pressure, or increased abdominal obesity. MetS arises due to dysregulated metabolic pathways that culminate with insulin resistance and put individuals at risk to develop various comorbidities with far-reaching medical consequences such as non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease. As it stands, the exact pathogenesis of MetS as well as the involvement of the gastrointestinal tract in MetS is not fully understood. Our study aimed to evaluate intestinal health in human subjects with MetS. METHODS: We examined MetS risk factors in individuals through body measurements and clinical and biochemical blood analysis. To evaluate intestinal health, gut inflammation was measured by fecal calprotectin, intestinal permeability through the lactulose-mannitol test, and utilized fecal metabolomics to examine alterations in the host-microbiota gut metabolism. RESULTS: No signs of intestinal inflammation or increased intestinal permeability were observed in the MetS group compared to our control group. However, we found a significant increase in 417 lipid features of the gut lipidome in our MetS cohort. An identified fecal lipid, diacyl-glycerophosphocholine, showed a strong correlation with several MetS risk factors. Although our MetS cohort showed no signs of intestinal inflammation, they presented with increased levels of serum TNFα that also correlated with increasing triglyceride and fecal diacyl-glycerophosphocholine levels and decreasing HDL cholesterol levels. CONCLUSION: Taken together, our main results show that MetS subjects showed major alterations in fecal lipid profiles suggesting alterations in the intestinal host-microbiota metabolism that may arise before concrete signs of gut inflammation or intestinal permeability become apparent. Lastly, we posit that fecal metabolomics could serve as a non-invasive, accurate screening method for both MetS and NAFLD.
RESUMO
BACKGROUND: Shotgun injuries (SGI) are infrequent, but due its special ballistics, are related to adverse outcomes. OBJECTIVE: To analyze operative and administrative variables, critical for the institution. METHOD: Demographics and health-care related variables from SGI patients admitted to Military Central Hospital (Mexico City) between July 2006 and August 2019, were retrospectively studied. Statistics methods used were dispersion measures and relative occurrence frequency. RESULTS: Over a 15 months-span, 21 SGI patients were admitted. Mean age was 36.9 ± 13.6 years (range: 14-61) and male gender was dominant (n = 20; 95%). Type II SGI were the most common injuries (62%; 13/21). Mean hospital length of stay was 37.1 ± 28.7 days (range: 3-109) while stay at ICU was 20.3 ± 22.5 days (range: 3-99). Global rate of morbidity was 82% (17/21) and most frequent complications were infective. Global mortality rate was 24% (5/21). CONCLUSIONS: Once SGI cause prolonged length of stay, high rate of morbidity and of enormous consuming of material and human resources, primary prevention strategies are convenient for health-care systems compromised to the care of these cases.
ANTECEDENTES: Las lesiones por disparo de escopeta (LE) son infrecuentes, pero debido a su balística especial se relacionan con un pronóstico adverso. OBJETIVO: Analizar variables operativas y administrativas de los pacientes con LE, de interés para la institución. MÉTODO: Se estudiaron retrospectivamente variables demográficas y asistenciales de pacientes con LE admitidos al Hospital Central Militar (Ciudad de México) entre julio de 2006 y agosto de 2019. Los métodos estadísticos usados fueron medidas de dispersión y frecuencia relativa de ocurrencia. RESULTADOS: En 158 meses se admitieron 21 pacientes con LE. La edad media fue de 36.9 ± 13.6 años (rango: 14-61) y predominó el sexo masculino (n = 20; 95%). La LE tipo II fue la más frecuente (62%; 13/21). La estancia hospitalaria media fue de 37.1 ± 28.7 días (rango: 3-109) y en cuidados intensivos fue de 20.3 ± 22.5 días (rango: 3-99). La tasa global de morbilidad fue del 82% (17/21) y las complicaciones más frecuentes fueron infecciosas. La tasa gobal de mortalidad fue del 24% (5/21). CONCLUSIONES: Las LE son causa de estancia hospitalaria prolongada, alta tasa de morbilidad y un enorme consumo de recursos humanos y materiales, por lo que las estrategias de prevención primaria son convenientes para los sistemas de salud comprometidos con el cuidado de estos casos.
