Oral pregabalin is effective as preemptive analgesia in abdominal hysterectomy-A randomized controlled trial.

Postoperative pain is one of the main negative symptoms resulting from surgery and the use of new methods to control this symptom is of ever-increasing relevance. Opioid-sparing strategies, such as multimodal analgesia, are trends in this scenario. Pregabalin is a well-established treatment for neuropathic pain; however, it is still controversial in the surgical context for postoperative analgesia. This study investigated the effect of pregabalin on postoperative analgesia in patients undergoing abdominal hysterectomy. It is a prospective, randomised, double-blind, placebo-controlled clinical trial. Female patients undergoing abdominal hysterectomy were randomised to use pregabalin (group P1), 300 mg orally 2 h before surgery, or identical placebo pills (group P0). The main outcome includes the postoperative pain index by visual analogue scale (VAS) and McGill's pain questionnaire. Secondary outcomes include opioid consumption and the presence of adverse effects. A value of p < 0.05 was used to reject type I error. Fifty-five patients were randomised amongst the groups. Patients in group P1 had lower pain rates by VAS scale, both at rest and in active motion, than group P0. In McGill's questionnaire, patients from group P1 also had lower pain rates (12 × 28.5). There was approximately twice as much opioid consumption amongst patients in group P0. Regarding side effects, there was a difference between the two groups only for dizziness, being more incident in group P1. This study suggests that pregabalin is an important adjuvant drug in treating postoperative pain in patients with abdominal hysterectomy.

A Critical Review of Analytical Methods in Pharmaceutical Matrices for Determination of Corticosteroids.

Corticosteroids are a class of hormones released by the adrenal cortex, which includes glucocorticoids and mineralocorticoids. Glucocorticoids have an important role in the metabolism of carbohydrates, proteins and calcium and effective anti-inflammatory and immunosuppressive activity. Due to their intense immunomodulatory and anti-inflammatory activity, glucocorticoids are used in the treatment of various inflammatory, malignant, allergic conditions such as rhinitis, asthma, dermatological, rheumatic, ophthalmic and neurological diseases, as well as after organ transplants. They are the most widely prescribed drugs in the world. The objective of this review is to provide an overview of the analytical methods in pharmaceutical matrices for determination of corticosteroids. In this study, the predominance of liquid chromatography methods for the analysis of corticosteroids from pharmaceutical products is evident for both liquid and semisolid dosage forms as well as for solids. The same can be said for topical, oral and parenteral formulations. Methods such as spectrophotometry are also used, but given the advantages of chromatographic methods such as better selectivity and sensitivity, they have become the choice for analysis of these drugs, however, most methods still do not meet the credentials of "green chemistry."

Avaliação do desempenho do plasma humano em relação aoplasma de coelho no teste da coagulase livre / Performance evaluation of the human plasma in relation to the rabbit plasma in the test of free coagulase

Objetivo: Esse estudo visa comparar o desempenho do plasma humano com o plasma de coelho padronizado na técnica da coagulase livre para Diagnóstico de Staphylococcus aureus, verificando a viabilidade da Substituição. Métodos: Foi realizada a comparação do desempenho de ambos os plasmas colhidos com EDTA, através da prova da coagulase livre em tubo, utilizando 34 isolados de Staphylococcus aureus. Resultados: Dos 34 isolados de Staphylococcus aureus de amostras clínicas, todos (100%) coagularam o plasma de coelho e o plasma humano com Heparina e 15 (44%) coagularam o plasma humano com EDTA. Conclusão: Visto que o uso do plasma de coelho é o reagente padronizado para realização da prova da coagulase livre em tubo, na identificação de Staphylococcus aureus, os resultados obtidos indicam a possibilidade de substituição do plasma de coelho comercialmente disponível por plasma humano colhido com heparina, diminuindo os custos com esse procedimento laboratorial.