HDL cholesterol levels in children with mild hypercholesterolemia: effect of consuming skim milk enriched with olive oil and modulation by the TAQ 1B polymorphism in the CETP gene.

BACKGROUND: This study aimed to examine the changes in serum lipids in children with mild hypercholesterolemia after the use of skim milk or olive-oil-enriched skim milk in their diet and the modulation of lipid levels by the Taq 1B polymorphism in the cholesteryl-ester transfer protein gene. METHODS: Thirty-six prepubertal children with mild hypercholesterolemia were randomly assigned in a crossover design into 2 groups of 16 and 20 individuals. Both groups received, in sequential inverse order, the 2 types of milk for 2 periods of 6 weeks. RESULTS: Carriers of at least 1 B2 allele had an adjusted basal HDL cholesterol level significantly higher than children with the B1B1 genotype (1.291 mmol/l, 95% CI: 1.184-1.397, vs. 1.082 mmol/l, 95% CI: 0.931-1.233; p = 0.027). In contrast, there were no significant differences in the adjusted basal levels of apolipoprotein A-I (B2 carriers: 1.292 g/l, 95% CI: 1.218-1.367; B1B1 genotype: 1.215 g/l, 95% CI: 1.109-1.320; p = 0.223). The intake of olive-oil-enriched skim milk caused significant increases in HDL cholesterol and apolipoprotein A-I, both in B2 (0.089 mmol/l, 95% CI: 0.032-0.146, p = 0.005; 0.55 g/l, 95% CI: 0.012-0.098; p = 0.018) and in B1B1 carriers (0.179 mmol/l, 95% CI: 0.096-0.262; p < 0.001; and 0.095 g/l, 95% CI: 0.032-0.157; p = 0.003). This increase in HDL cholesterol was significantly higher in the B1B1 group (p = 0.049). CONCLUSION: The consumption of skim milk enriched with olive oil increases the HDL cholesterol and apolipoprotein A-I levels in children with hypercholesterolemia, this effect being more intense in carriers of the B1B1 genotype.

[Prevalence of obesity and overweight in adolescents from Canary Islands, Spain. Relationship with breakfast and physical activity]. / Prevalencia de obesidad y sobrepeso en adolescentes canarios. Relación con el desayuno y la actividad física.

BACKGROUND AND OBJECTIVE: To estimate the prevalence of obesity and overweight in Canary adolescents, evaluating its association with breakfast intake and physical activity. SUBJECTS AND METHOD: Cross-sectional study of a representative sample of children aged 12-14 years living in the island of Gran Canaria. They were weighed and measured and the prevalence of overweight and obesity was determined according to the 85th and 97th percentiles of the Spanish body mass index tables. Breakfast and physical activity characteristics were also studied using questionnaires. RESULTS: The overall prevalence of obesity and overweight was 26.1%, higher in females (29.5%) than in males (22.8%). Obesity affects 14.8% of all teenagers (17.6% of girls and 12.0% of boys). Highest overweight and obesity levels affect those aged 12 years, decreasing progressively with age. Those boys who have a more complete breakfast have lower prevalence rates. There was no association between obesity and overweight with physical activity, as measured by the number of hours devoted to watching television or playing videogames as opposed to hours devoted to sport. CONCLUSIONS: The prevalence of overweight and obesity is high, especially in girls. We observed an inverse relationship between breakfast and its quality and obesity.