Anterior tibiofemoral dislocation after total knee arthroplasty: A case report and literature review.

Anterior tibiofemoral dislocation after total knee arthroplasty is an extremely rare and serious event. Amongst English-published papers, we found only 15 relevant cases, 3 of which presented vascular complications. This manuscript aims to present a 77-year-old woman with a TC-Plus (Smith & Nephew) cruciate-retaining type in first time of knee prosthesis, who suffered an anterior tibiofemoral dislocation and were admitted to our hospital. The clinical management and outcome were evaluated. Furthermore, a review of literature was performed. We concluded that early detection and surgical intervention of vascular injury is the key in the survival of the limbs. If there is still knee instability after acute recovery, it seems that revision surgery with constrained total knee arthroplasty can bring about good clinical and functional results.

Estado nutricional y hábitos alimenticios en un equipo de fútbol profesional / Nutritional status and feeding habits in a professional soccer team

Pese a que el fútbol es el deporte más popular del planeta, la nutrición del futbolista está ciertamente descuidada. La actividad física exige una utilización mixta de los sistemas fisiológicos de obtención de energía, aeróbico y anaeróbico, requiriéndose una completa ingesta de nutrientes; siendo de sobra conocido el papel de los carbohidratos en el rendimiento deportivo. OBJETIVOS: El objetivo de este estudio es determinar la ingesta nutricional de macronutrientes en un equipo de fútbol profesional. MATERIAL Y MÉTODOS: Realizamos un estudio epidemiológico, descriptivo y prospectivo de la primera plantilla de un equipo de la Segunda División B española. Se trata de 22 jugadores masculinos, con edad media de 26,19 (19,5-31,6). Elaboramos un protocolo de recogida de alimentos ingeridos durante 7 días, contabilizando la ingesta de macronutrientes y cuantificándose el gasto energético total, variable en función del día de entrenamiento y posición del jugador. RESULTADOS: El total de carbohidratos globales consumidos fue de 305,07 +/- 56 gr (48,78% de las calorías). Estos valores varían entre el día de actividad moderada: 213,6 +/- 37 gr (39,93%) y el día de actividad intensa: 361,84 +/- 28 gr (49,21%). Existen diferencias significativas en el total de carbohidratos según la actividad diaria. Además, encontramos diferencias significativas en la altura del jugador, su tasa metabólica basal y gasto energético total, entre las posiciones de portero y jugador de banda avanzado (p < 0,05). DISCUSIÓN Y CONCLUSIONES: Tanto el aporte de carbohidratos como la cantidad global de calorías consumidas por el futbolista se encuentran por debajo del estándar recomendado (3600 kcal/día)

Despite soccer is the most popular sport on the planet, soccer player nutrition is certainly neglected. Physical activity requires a mixed use of the physiological systems for obtaining energy, requiring a complete intake of nutrients; and the role of carbohydrates in sports performance is well known. OBJECTIVES: The objective of this study is to determine the nutritional intake of macronutrients in a professional soccer team. MATERIAL AND METHODS: We carried out an epidemiological, descriptive and prospective study of a Spanish Second Division B team. They were 22 male players, with a mean age of 26.19 (19.5-31.6). We elaborated a protocol for collecting food eaten for 7 days, counting the macronutrient intake and quantifying the total energy expenditure, which varies depending on the training day and the player's position. RESULTS: The global carbohydrates consumed was 305.07+/- 56 gr (48.78% of calories). These values vary between the moderate activity day: 213.6 +/- 37 grams (39.93%) and the intense activity day: 361.84 +/- 28 grams (49.21%). We found significant differences in total carbohydrates based on daily activity. In addition, we found significant differences in the player height, their basal metabolic rate and total energy expenditure, between the positions of goal keeper and advanced band player (p <0.05). DISCUSSION AND CONCLUSIONS: Both carbohydrate intake and the overall amount of calories consumed by the footballer are below the recommended standard (3600 kcal / day)

New Insights into the Design and Application of a Passive Acoustic Monitoring System for the Assessment of the Good Environmental Status in Spanish Marine Waters.

Passive acoustic monitoring systems allow for non-invasive monitoring of underwater species and anthropogenic noise. One of these systems has been developed keeping in mind the need to create a user-friendly tool to obtain the ambient noise indicators, while at the same time providing a powerful tool for marine scientists and biologists to progress in studying the effect of human activities on species and ecosystems. The device is based on a low-power processor with ad-hoc electronics, ensuring that the system has efficient energy management, and that the storage capacity is large enough to allow deployments for long periods. An application is presented using data from an acoustic campaign done in 2018 at El Gorguel (Cartagena, Spain). The results show a good agreement between theoretical maps created using AIS data and the ambient noise level indicators measured in the frequency bands of 63 Hz and 125 Hz specified in the directive 11 of the EU Marine Strategy Framework Directive. Using a 2D representation, these ambient noise indicators have enabled repetitive events and daily variations in boat traffic to be identified. The ship noise registered can also be used to track ships by using the acoustic signatures of the engine propellers' noise.

Systemic administration of a fibroblast growth factor receptor 1 agonist rescues the cognitive deficit in aged socially isolated rats.

Social isolation predominantly occurs in elderly people and it is strongly associated with cognitive decline. However, the mechanisms that produce isolation-related cognitive dysfunction during aging remain unclear. Here, we evaluated the cognitive, electrophysiological, and morphological effects of short- (4 weeks) and long-term (12 weeks) social isolation in aged male Wistar rats. Long-term but not short-term social isolation increased the plasma corticosterone levels and impaired spatial memory in the Morris water maze. Moreover, isolated animals displayed dampened hippocampal long-term potentiation in vivo, both in the dentate gyrus (DG) and CA1, as well as a specific reduction in the volume of the stratum oriens and spine density in CA1. Interestingly, social isolation induced a transient increase in hippocampal basic fibroblast growth factor (FGF2), whereas fibroblast growth factor receptor 1 (FGFR1) levels only increased after long-term isolation. Importantly, subchronic systemic administration of FGL, a synthetic peptide that activates FGFR1, rescued spatial memory in long-term isolated rats. These findings provide new insights into the neurobiological mechanisms underlying the detrimental effects on memory of chronic social isolation in the aged.

Contextual imitation of intransitive body actions in a Beluga whale (Delphinapterus leucas): A "do as other does" study.

Cetaceans are remarkable for exhibiting group-specific behavioral traditions or cultures in several behavioral domains (e.g., calls, behavioral tactics), and the question of whether they can be acquired socially, for example through imitative processes, remains open. Here we used a "Do as other does" paradigm to experimentally study the ability of a beluga to imitate familiar intransitive (body-oriented) actions demonstrated by a conspecific. The participant was first trained to copy three familiar behaviors on command (training phase) and then was tested for her ability to generalize the learned "Do as the other does" command to a different set of three familiar behaviors (testing phase). We found that the beluga (1) was capable of learning the copy command signal "Do what-the-other-does"; (2) exhibited high matching accuracy for trained behaviors (mean = 84% of correct performance) after making the first successful copy on command; (3) copied successfully the new set of three familiar generalization behaviors that were untrained to the copy command (range of first copy = 12 to 35 trials); and (4) deployed a high level of matching accuracy (mean = 83%) after making the first copy of an untrained behavior on command. This is the first evidence of contextual imitation of intransitive (body-oriented) movements in the beluga and adds to the reported findings on production imitation of sounds in this species and production imitation of sounds and motor actions in several cetaceans, especially dolphins and killer whales. Collectively these findings highlight the notion that cetaceans have a natural propensity at skillfully and proficiently matching the sounds and body movements demonstrated by conspecifics, a fitness-enhancing propensity in the context of cooperative hunting and anti-predatory defense tactics, and of alliance formation strategies that have been documented in these species' natural habitats. Future work should determine if the beluga can also imitate novel motor actions.

Hippocampal Dendritic Spines Are Segregated Depending on Their Actin Polymerization.

Dendritic spines are mushroom-shaped protrusions of the postsynaptic membrane. Spines receive the majority of glutamatergic synaptic inputs. Their morphology, dynamics, and density have been related to synaptic plasticity and learning. The main determinant of spine shape is filamentous actin. Using FRAP, we have reexamined the actin dynamics of individual spines from pyramidal hippocampal neurons, both in cultures and in hippocampal organotypic slices. Our results indicate that, in cultures, the actin mobile fraction is independently regulated at the individual spine level, and mobile fraction values do not correlate with either age or distance from the soma. The most significant factor regulating actin mobile fraction was the presence of astrocytes in the culture substrate. Spines from neurons growing in the virtual absence of astrocytes have a more stable actin cytoskeleton, while spines from neurons growing in close contact with astrocytes show a more dynamic cytoskeleton. According to their recovery time, spines were distributed into two populations with slower and faster recovery times, while spines from slice cultures were grouped into one population. Finally, employing fast lineal acquisition protocols, we confirmed the existence of loci with high polymerization rates within the spine.

Lipid dynamics at dendritic spines.

Dynamic changes in the structure and composition of the membrane protrusions forming dendritic spines underlie memory and learning processes. In recent years a great effort has been made to characterize in detail the protein machinery that controls spine plasticity. However, we know much less about the involvement of lipids, despite being major membrane components and structure determinants. Moreover, protein complexes that regulate spine plasticity depend on specific interactions with membrane lipids for proper function and accurate intracellular signaling. In this review we gather information available on the lipid composition at dendritic spine membranes and on its dynamics. We pay particular attention to the influence that spine lipid dynamism has on glutamate receptors, which are key regulators of synaptic plasticity.

WIP modulates dendritic spine actin cytoskeleton by transcriptional control of lipid metabolic enzymes.

We identify Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) as a novel component of neuronal synapses whose absence increases dendritic spine size and filamentous actin levels in an N-WASP/Arp2/3-independent, RhoA/ROCK/profilinIIa-dependent manner. These effects depend on the reduction of membrane sphingomyelin (SM) due to transcriptional upregulation of neutral sphingomyelinase (NSM) through active RhoA; this enhances RhoA binding to the membrane, raft partitioning and activation in steady state but prevents RhoA changes in response to stimulus. Inhibition of NSM or SM addition reverses RhoA, filamentous actin and functional anomalies in synapses lacking WIP. Our findings characterize WIP as a link between membrane lipid composition and actin cytoskeleton at dendritic spines. They also contribute to explain cognitive deficits shared by individuals bearing mutations in the region assigned to the gene encoding for WIP.

The pulsed to tonal strength parameter and its importance in characterizing and classifying Beluga whale sounds.

A large number of the vocalization studies on mammals are based on time-frequency analysis of the produced sounds. The patterns, which are extracted from the time-frequency representations, determine the classification in the different sound categories. However, there are situations where this pattern related recognition does not allow a precise characterization of the vocalization to be obtained. In these situations, a feasible alternative, which can help by giving the dominant component of the sound, is to measure the strength of the tonal and pulsed constituent units. In this work, the use of a ratio of pulsed to tonal strength is proposed to objectively measure the distribution of energy between these two components. This pulsed to tonal ratio (PTR) can be computed with the aid of the discrete cosine transform. It is demonstrated that the PTR can be obtained with a relatively simple expression without having to go through the time- frequency representation. This work presents examples that show how the PTR can be used to distinguish between two very similar Beluga whale sounds and how to dynamically track the power distribution between the pulsed and tonal components in non-stationary signals.

[Inappropriate multiple medication and prescribing of drugs immobile elderly patients living in the community]. / Polimedicación y prescripción de fármacos inadecuados en pacientes ancianos inmovilizados que viven en la comunidad.

OBJECTIVES: To ascertain and analyse the drug consumption of the immobile elderly, as well as the number of potentially inappropriate medications (PIM). DESIGN: Cross-sectional study. SETTING: Fourteen rural primary care centres. PARTICIPANTS: Non-institutionalised immobile patients, older than 64 years were selected by systematic sampling. PRINCIPAL MEASUREMENTS: Review of patients' medicine cabinets and noting the daily doses and current number of drugs, as well as the origin of the prescription. Identification of PIM (Beers criteria). RESULTS: One-hundred forty-three homes visits were made. The mean age was 81.3+/-7.9 years, of whom 74.8% were women. The most common drugs were: analgesics (9.2%), antacids (7.1%), nitrites-calcium antagonists (6.5%), non-steroidal anti-inflammatories (5.0%), and angiotensin converting enzyme inhibitors (4.7%). The percentage of patients who took more than 4 drugs was 76.1%. A PIM was taken by 35% of the elderly. The most common were: long-acting tranquilisers (41.5%), hypnotics (13.8%), digoxin (13.8%), indomethacin (7.7%), and antispasmodics (6.1%). In the majority of cases, the prescribing of the PIM was made by the family doctor (77.7%). Women took significantly more inappropriate drugs than men (0.50+/-0.72 vs to 0.25+/-0.50; P=.001) and those on multiple medication more than those not on multiple medication (0.50+/-0.73 vs 0.31+/-0.52; P=.008). CONCLUSIONS: The prevalence of inappropriate therapy in the immobile elderly is high, therefore an effort must be made to reduce it. Procedures directed towards increasing the quality of prescribing could improve the state of health and quality of life of these patients.

Polimedicación y prescripción de fármacos inadecuados en pacientes ancianos inmovilizados que viven en la comunidad / Inappropriate multiple medication and prescribing of drugs inmmobile elderly patients living in the community

Diseño. Estudio transversal. Emplazamiento. Catorce centros rurales de atención primaria. Participantes. Se escogió mediante muestreo sistemático a pacientes inmovilizados, mayores de 64 años, no institucionalizados. Mediciones principales. Revisión de los botiquines y anotación de la dosis diaria y el número de fármacos actuales del paciente, así como el origen de la prescripción. Identificación de los FPI (criterios de Beers). Estadística descriptiva e inferencial. Resultados. Se visitaron 143 domicilios. La media de edad fue de 81,3 ± 7,9 años, con un 74,8% de mujeres. Los medicamentos más comunes fueron: analgésicos (9,2%), antiácidos (7,1%), nitritos-antagonistas del calcio (6,5%), antiinflamatorios no esteroideos (5,0%) e inhibidores de la enzima de conversión de la angiotensina (4,7%). El porcentaje de pacientes con consumo de más de 4 fármacos fue del 76,1%. El 35% de los ancianos tomaba algún FPI. Los más frecuentes fueron: ansiolíticos de acción prolongada (41,5%), hipnóticos (13,8%), digoxina (13,8%), indometacina (7,7%) y espasmolíticos (6,1%). En la mayor parte de los casos, la prescripción de los FPI partió del médico de familia (77,7%). Las mujeres tomaban significativamente más fármacos inapropiados que los varones (0,50 ± 0,72 frente a 0,25 ± 0,50; p = 0,001) y los polimedicados, más que los no polimedicados (0,50 ± 0,73 frente a 0,31 ± 0,52; p = 0,008). Conclusiones. La prevalencia de inadecuación terapéutica en los ancianos inmovilizados es alta, por lo que es necesario hacer un esfuerzo para reducirla. Actuaciones dirigidas a aumentar la calidad de las prescripciones podrían mejorar el estado de salud y la calidad de vida de estos pacientes

Objectives. To ascertain and analyse the drug consumption of the immobile elderly, as well as the number of potentially inappropriate medcations (PIM). Design. Cross-sectional study. Setting. Fourteen rural primary care centres. Participants. Non-institutionalised immobile patients, older than 64 years were selected by systematic sampling. Principal measurements. Review of patients' medicine cabinets and noting the daily doses and current number of drugs, as well as the origin of the prescription. Identification of PIM (Beers criteria). Results. One-hundred forty-three homes visits were made. The mean age was 81.3±7.9 years, of whom 74.8% were women. The most common drugs were: analgesics (9.2%), antacids (7.1%), nitrites-calcium antagonists (6.5%), non-steroidal anti-inflammatories (5.0%), and angiotensin converting enzyme inhibitors (4.7%). The percentage of patients who took more than 4 drugs was 76.1%. A PIM was taken by 35% of the elderly. The most common were: long-acting tranquilisers (41.5%), hypnotics (13.8%), digoxin (13.8%), indomethacin (7.7%), and antispasmodics (6.1%). In the majority of cases, the prescribing of the PIM was made by the family doctor (77.7%). Women took significantly more inappropriate drugs than men (0.50±0.72 vs to 0.25±0.50; P=.001) and those on multiple medication more than those not on multiple medication (0.50±0.73 vs 0.31±0.52; P=.008). Conclusions. The prevalence of inappropriate therapy in the immobile elderly is high, therefore an effort must be made to reduce it. Procedures directed towards increasing the quality of prescribing could improve the state of health and quality of life of these patients