¿Podría ser útil la resonancia magnética de estrés en pacientes con baja probabilidad de cardiopatía isquémica? / Could stress magnetic resonance imaging be useful in patients with a low probability of ischemic heart disease?

Objetivo: Evaluar la utilidad de la resonancia magnética cardiaca de estrés (RMCE) con adenosina en la detección de cardiopatía isquémica en pacientes con baja probabilidad preprueba. Material y Métodos: Se evaluó la utilidad de la RMCE en una selección de pacientes con baja probabilidad preprueba (riesgo cardiovascular bajo o moderado, dolor torácico atípico o ausencia de cardiopatía isquémica previa) mediante el uso del cociente de probabilidad. Resultados: Se incluyeron 295 pacientes, con un seguimiento de 28 (19-36) meses. Un total de 60 pacientes presentaron un evento. Se observó una mayor utilidad de la RMCE en los pacientes con una probabilidad preprueba baja: dolor torácico atípico (cociente de probabilidad [CP] positivo 8,56), ausencia de cardiopatía isquémica previa (CP positivo 4,85) y riesgo cardiovascular bajo o moderado (CP positivo 3,87). Conclusiones: La RMCE puede ser una técnica útil en el diagnóstico de cardiopatía isquémica en pacientes con baja probabilidad preprueba

Objective: To assess the usefulness of cardiac stress magnetic resonance imaging (MRI) with adenosine in the detection of ischemic heart disease in patients with a low pretest probability of disease. Material and methods: We used the probability ratio to analyze the usefulness of cardiac stress MRI in a selection of patients with a low pretest probability of ischemic heart disease (low or moderate cardiovascular risk, atypical chest pain, or absence of prior ischemic heart disease). Results: We included 295 patients followed up for a median of 28 (19-36) months. A total de 60 patients had an event. Cardiac stress MRI was more useful in patients with a low pretest probability: atypical chest pain (probability ratio [PR] positive 8.56), absence of prior ischemic heart disease (PR positive 4.85), and low or moderate cardiovascular risk (PR positive 3.87). Conclusions: Cardiac stress MRI can be useful in the diagnosis of ischemic heart disease in patients with a low pretest probability

Could stress magnetic resonance imaging be useful in patients with a low probability of ischemic heart disease? / ¿Podría ser útil la resonancia magnética de estrés en pacientes con baja probabilidad de cardiopatía isquémica?

OBJECTIVE: To assess the usefulness of cardiac stress magnetic resonance imaging (MRI) with adenosine in the detection of ischemic heart disease in patients with a low pretest probability of disease. MATERIAL AND METHODS: We used the probability ratio to analyze the usefulness of cardiac stress MRI in a selection of patients with a low pretest probability of ischemic heart disease (low or moderate cardiovascular risk, atypical chest pain, or absence of prior ischemic heart disease). RESULTS: We included 295 patients followed up for a median of 28 (19-36) months. A total de 60 patients had an event. Cardiac stress MRI was more useful in patients with a low pretest probability: atypical chest pain (probability ratio [PR] positive 8.56), absence of prior ischemic heart disease (PR positive 4.85), and low or moderate cardiovascular risk (PR positive 3.87). CONCLUSIONS: Cardiac stress MRI can be useful in the diagnosis of ischemic heart disease in patients with a low pretest probability.

Neuroprotective Effects of Selected Microbial-Derived Phenolic Metabolites and Aroma Compounds from Wine in Human SH-SY5Y Neuroblastoma Cells and Their Putative Mechanisms of Action.

Moderate wine consumption has shown the potential to delay the onset of neurodegenerative diseases. This study investigates the molecular mechanisms underlying the protective effects of wine-derived phenolic and aroma compounds in a neuroinflammation model based on SIN-1 stress-induced injury in SH-SY5Y neuroblastoma cells. Cell pretreatment with microbial metabolites found in blood after wine consumption, 3,4-dihydroxyphenylacetic (3,4-DHPA), 3-hydroxyphenylacetic acids and salicylic ß-d-O-glucuronide, at physiologically concentrations (0.1-10 µM) resulted in increased cell viability versus SIN-1 control group (p < 0.05). Results also showed significant decreases in mitogen-activated protein kinase (MAPK) p38 and ERK1/2 activation as well as in downstream pro-apoptotic caspase-3 activity by some of the studied compounds. Moreover, pretreatment with p38, MEK, and ERK1/2-specific inhibitors, which have a phenolic-like structure, also resulted in an increase on cell survival and a reduction on caspase-3 activity levels. Overall, these results contribute with new evidences related to the neuroprotective actions of wine, pointing out that wine-derived human metabolites and aroma compounds may be effective at protecting neuroblastoma cells from nitrosative stress injury by inhibiting neuronal MAPK p38 and ERK1/2, as well as downstream caspase 3 activity.