RESUMO
Objetivo: Evaluar la utilidad de la resonancia magnética cardiaca de estrés (RMCE) con adenosina en la detección de cardiopatía isquémica en pacientes con baja probabilidad preprueba. Material y Métodos: Se evaluó la utilidad de la RMCE en una selección de pacientes con baja probabilidad preprueba (riesgo cardiovascular bajo o moderado, dolor torácico atípico o ausencia de cardiopatía isquémica previa) mediante el uso del cociente de probabilidad. Resultados: Se incluyeron 295 pacientes, con un seguimiento de 28 (19-36) meses. Un total de 60 pacientes presentaron un evento. Se observó una mayor utilidad de la RMCE en los pacientes con una probabilidad preprueba baja: dolor torácico atípico (cociente de probabilidad [CP] positivo 8,56), ausencia de cardiopatía isquémica previa (CP positivo 4,85) y riesgo cardiovascular bajo o moderado (CP positivo 3,87). Conclusiones: La RMCE puede ser una técnica útil en el diagnóstico de cardiopatía isquémica en pacientes con baja probabilidad preprueba
Objective: To assess the usefulness of cardiac stress magnetic resonance imaging (MRI) with adenosine in the detection of ischemic heart disease in patients with a low pretest probability of disease. Material and methods: We used the probability ratio to analyze the usefulness of cardiac stress MRI in a selection of patients with a low pretest probability of ischemic heart disease (low or moderate cardiovascular risk, atypical chest pain, or absence of prior ischemic heart disease). Results: We included 295 patients followed up for a median of 28 (19-36) months. A total de 60 patients had an event. Cardiac stress MRI was more useful in patients with a low pretest probability: atypical chest pain (probability ratio [PR] positive 8.56), absence of prior ischemic heart disease (PR positive 4.85), and low or moderate cardiovascular risk (PR positive 3.87). Conclusions: Cardiac stress MRI can be useful in the diagnosis of ischemic heart disease in patients with a low pretest probability
Assuntos
Humanos , Espectroscopia de Ressonância Magnética/métodos , Isquemia Miocárdica/diagnóstico por imagem , Síndrome Coronariana Aguda/diagnóstico por imagem , Fatores de Risco , Análise Custo-Benefício/estatística & dados numéricos , Estudos Prospectivos , Sensibilidade e EspecificidadeRESUMO
OBJECTIVE: To assess the usefulness of cardiac stress magnetic resonance imaging (MRI) with adenosine in the detection of ischemic heart disease in patients with a low pretest probability of disease. MATERIAL AND METHODS: We used the probability ratio to analyze the usefulness of cardiac stress MRI in a selection of patients with a low pretest probability of ischemic heart disease (low or moderate cardiovascular risk, atypical chest pain, or absence of prior ischemic heart disease). RESULTS: We included 295 patients followed up for a median of 28 (19-36) months. A total de 60 patients had an event. Cardiac stress MRI was more useful in patients with a low pretest probability: atypical chest pain (probability ratio [PR] positive 8.56), absence of prior ischemic heart disease (PR positive 4.85), and low or moderate cardiovascular risk (PR positive 3.87). CONCLUSIONS: Cardiac stress MRI can be useful in the diagnosis of ischemic heart disease in patients with a low pretest probability.
Assuntos
Teste de Esforço/métodos , Imageamento por Ressonância Magnética , Isquemia Miocárdica/diagnóstico por imagem , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos ProspectivosRESUMO
Moderate wine consumption has shown the potential to delay the onset of neurodegenerative diseases. This study investigates the molecular mechanisms underlying the protective effects of wine-derived phenolic and aroma compounds in a neuroinflammation model based on SIN-1 stress-induced injury in SH-SY5Y neuroblastoma cells. Cell pretreatment with microbial metabolites found in blood after wine consumption, 3,4-dihydroxyphenylacetic (3,4-DHPA), 3-hydroxyphenylacetic acids and salicylic ß-d-O-glucuronide, at physiologically concentrations (0.1-10 µM) resulted in increased cell viability versus SIN-1 control group (p < 0.05). Results also showed significant decreases in mitogen-activated protein kinase (MAPK) p38 and ERK1/2 activation as well as in downstream pro-apoptotic caspase-3 activity by some of the studied compounds. Moreover, pretreatment with p38, MEK, and ERK1/2-specific inhibitors, which have a phenolic-like structure, also resulted in an increase on cell survival and a reduction on caspase-3 activity levels. Overall, these results contribute with new evidences related to the neuroprotective actions of wine, pointing out that wine-derived human metabolites and aroma compounds may be effective at protecting neuroblastoma cells from nitrosative stress injury by inhibiting neuronal MAPK p38 and ERK1/2, as well as downstream caspase 3 activity.