Sudden Death Due to Thrombosis Associated with Implantable Cardioverter-Defibrillator Electrodes.

Thrombosis associated with pacemaker leads is extremely rare, although the literature on this subject is scarce. A clinical case is reported, describing this condition and its clinical presentation, the complementary tests for establishing the diagnosis and the available therapeutic options. LEARNING POINTS: Thrombosis associated with pacemaker leads is extremely rare.The different causes that contribute to thrombosis all have Virchow's triad (blood stasis, endothelial injury/dysfunction and hypercoagulability) in common.Transthoracic and/or transoesophageal Doppler echocardiography is the gold standard for establishing the diagnosis, while the treatment options are anticoagulation, thrombolysis and surgical or endovascular embolectomy.

Prior Treatment with Statins is Associated with Improved Outcomes of Patients with COVID-19: Data from the SEMI-COVID-19 Registry.

BACKGROUND: The impact of statins on COVID-19 outcomes is important given the high prevalence of their use among individuals at risk for severe COVID-19. Our aim is to assess whether patients receiving chronic statin treatment who are hospitalized with COVID-19 have reduced in-hospital mortality if statin therapy is maintained during hospitalization. METHODS: This work is a cross-sectional, observational, retrospective multicenter study that analyzed 2921 patients who required hospital admission at 150 Spanish centers included in the nationwide SEMI-COVID-19 Network. We compared the clinical characteristics and COVID-19 disease outcomes between patients receiving chronic statin therapy who maintained this therapy during hospitalization versus those who did not. Propensity score matching was used to match each statin user whose therapy was maintained during hospitalization to a statin user whose therapy was withdrawn during hospitalization. RESULTS: After propensity score matching, continuation of statin therapy was associated with lower all-cause mortality (OR 0.67, 0.54-0.83, p < 0.001); lower incidence of acute kidney injury (AKI) (OR 0.76,0.6-0.97, p = 0.025), acute respiratory distress syndrome (ARDS) (OR 0.78, 0.69- 0.89, p < 0.001), and sepsis (4.82% vs 9.85%, p = 0.008); and less need for invasive mechanical ventilation (IMV) (5.35% vs 8.57, p < 0.001) compared to patients whose statin therapy was withdrawn during hospitalization. CONCLUSIONS: Patients previously treated with statins who are hospitalized for COVID-19 and maintain statin therapy during hospitalization have a lower mortality rate than those in whom therapy is withdrawn. In addition, statin therapy was associated with a decreased probability that patients with COVID-19 will develop AKI, ARDS, or sepsis and decreases the need for IMV.

El ingreso hospitalario: una oportunidad para el cribado de diabetes / Hospital admission: an opportunity for diabetes screening

No disponible

Lesiones deportivas y psicología: Una revisión (2000-2009) / Sports injuries and psychology. A review (2000 – 2009)

Después de una trayectoria de investigación progresivamente en aumento desde los años 70 hasta final del siglo XX acerca de la relación entre lesiones deportivas y factores psicológicos, la primera década del nuevo siglo ofrece unas perspectivas muy interesantes en este campo de conocimiento. El objetivo de este estudio es revisar la bibliografía especializada publicada entre el año 2000 y el 2009, en esta área de conocimiento. Se ha utilizado la base de datos EBSCO Host, y se han analizado 96 artículos de investigación. De cada uno de ellos se han analizado las siguientes variables: a) Título de la revista; b) Año de publicación; c) País del primer autor; d) Número de autores; e) Líneas de investigación; f) Diseño de investigación; g) Muestra objeto de estudio; h) variables objeto de estudio; i) Instrumentos de registro; y j) Programas de intervención. Los resultados más significativos señalan que la revista que más artículos publica es Journal of Sport Rehabilitation, que los autores más prolíficos pertenecen al ámbito anglosajón, que la línea de investigación más productiva es la referida a los procesos de rehabilitación, con muestras de deportistas de rendimiento, que las variables más estudiadas son las estrategias cognitivas, que los instrumentos más utilizados son los tests y cuestionarios de autoinforme y que las técnicas más utilizadas en los programas de intervención psicológica son la visualización y la relajación (AU)

After a research career gradually increasing since the 70's to late twentieth century about the relationship between sports injuries and psychological factors, the first decade of the new century is very interesting insights in this field of knowledge. The aim of this study is to review the literature published between 2000 and 2009, this area of knowledge. We used the EBSCOHost database, and have analyzed 96 research articles. From each of them has analyzed the following variables: a) Title of (..) (AU)

Depois de uma trajetória progressiva de investigações sobre a relação entre lesões esportivas e fatores psicológicos, desde os anos 70 até o final do século XX, na primeira década do novo século apresentam umas perspectivas muito interessantes nesta área de conhecimento. O objetivo desse estudo é de revisar a bibliografia especializada publicada nessa área, entre os anos 2000 e 2009. Foi utilizada a base de dados (..) (AU)

Lesiones deportivas y psicología: una revisión (2000-2009) / Sports injuries and psychology. a review (2000 – 2009)

Después de una trayectoria de investigación progresivamente en aumento desde los años 70hasta final del siglo XX acerca de la relación entre lesiones deportivas y factores psicológicos, la primera década del nuevo siglo ofrece unas perspectivas muy interesantes en este campo de conocimiento. El objetivo de este estudio es revisar la bibliografía especializada publicada entre el año 2000 y el 2009, en esta área de conocimiento. Se ha utilizado la base de datos EBSCO Host, y se han analizado 96 artículos de investigación. De cada uno de ellos se han analizado las siguientes variables: a) Título de la revista; b) Año de publicación; c) País del primer autor; d) Número de autores; e) Líneas de investigación; f) Diseño de investigación; g) Muestra objeto de estudio; h) variables objeto de estudio; i) Instrumentos de registro; y j)Programas de intervención. Los resultados más significativos señalan que la revista que más artículos publica es Journal of Sport Rehabilitation, que los autores más prolíficos pertenecen al ámbito anglosajón, que la línea de investigación más productiva es la referida a los procesos de rehabilitación, con muestras de deportistas de rendimiento, que las variables más estudiadas son las estrategias cognitivas, que los instrumentos más utilizados son los tests y cuestionarios de autoinforme y que las técnicas más utilizadas en los programas de intervención psicológica son la visualización y la relajación (AU)

After a research career gradually increasing since the 70's to late twentieth century about the relationship between sports injuries and psychological factors, the first decade of the new centuryis very interesting insights in this field of knowledge. The aim of this study is to review the literature published between 2000 and 2009, this area of knowledge. We used the EBSCO Host data base, and have analyzed 96 research articles. From each of them has analyzed the following variables: a) Title of the journal, b) Year of publication; c) Country of first author; d) Number of authors; e) Research lines f) Design Research; g) Sample under study, h) variables under study; i) recording instruments; j) Intervention programs. The most significant results indicate that the magazine is published more articles Journal of Sport Rehabilitation, the most prolific authors belong to the Anglo-Saxon, the most productive line of research is that related to the rehabilitation process, with samples of athletes performance, that the variables studied are the cognitive strategies, that the instruments used are the self tests and questionnaires, and that the techniques used in psychological intervention programs are visualization and relaxation (AU)

Depois de uma trajetória progressiva de investigações sobre a relação entre lesões esportivas efatores psicológicos, desde os anos 70 até o final do século XX, na primeira década do novo século apresentam umas perspectivas muito interessantes nesta área de conhecimento. O objetivo desse estudo é de revisar a bibliografia especializada publicada nessa área, entre osanos 2000 e 2009. Foi utilizada a base de dados EBSCO Host, sendo analisados 96 artigos científicos e de cada um deles foram analisadas as seguintes variáveis: a) Título da revista; b)Ano de publicação; c) País do primeiro autor; d) Número de autores; e) Linha de investigação; f)Desenho de investigação; g) Amostra objeto de estudo; h) Variável objeto de estudo; i)Instrumentos de registro; j) Programas de intervenção. Os resultados mais significativos apontam que a revista que mais publicou artigos é a Journal of Sport Rehabilitation, que os autores mais prolíficos pertencem ao âmbito anglo saxônico, que a linha de investigação com mais produção científica é a que se refere aos processos de reabilitação com esportistas de alto rendimento,que as variáveis mais estudadas são as estratégias cognitivas, que os instrumentos mais utilizados são os testes e questionários de auto-informe e que as técnicas mais utilizadas nos programa de intervenção psicológica são a visualização e a relaxação (AU)

The synthesis of androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta.

Androstane brassinosteroid analogues with alpha-azido acid ester groups in position 17beta were synthesized from 2alpha,3alpha,17beta-trihydroxy-5alpha-androstan-6-one after the protection of the 2alpha,3alpha-diols upon treatment with the corresponding alpha-azido acid and the subsequent deprotection of the diol grouping. Six new castasterone analogues were prepared. The biological activities were evaluated in two bioassays: a rice lamina inclination test and bean second internode bioassays. The activities of the new analogues differ in these two bioassays.